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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hip dysplasia is an important cause of osteoarthrosis of the hip, especially in Japanese. Recently, the role of the acetabular labrum in hip diseases has attracted the attention of researchers, but the condition of the labrum in the dysplastic hips has not been described. We used radial MRI to measure the degree of coverage of the femoral head by the acetabulum and the labrum, corresponding to 7 positions on the acetabular rim at every 15 degrees from anterosuperior 45 degrees via midsuperior to posterosuperior 45 degrees. 38 Japanese patients (51 hips) with dysplasia, and 11 healthy controls 122 hips) were studied. In the dysplastic hips, the labrum was larger than in the controls. We found no correlation between the coverage of the acetabulum in the anterosuperior positions and the size of the labrum among the dysplastic hips.
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PMID:Coverage of the femoral head by the acetabular labrum in dysplastic hips: quantitative analysis with radial MR imaging. 1289 48

Musculoskeletal conditions are increasingly common with advancing age. The life expectancy increased early and rapidly in Sweden, and today 17% of the population is over age 65. Musculoskeletal problems are therefore common but in general are receiving low attention, despite enormous costs for society. The indirect costs for musculoskeletal conditions vastly exceed direct costs (80% vs 20%). This is obviated by the fact that in 2001, of all persons receiving disability pension or taking longterm sick leave, 60% had a diagnosis related to the musculoskeletal system. Further, in a population of 9 million, 70,000 fragility fractures occur each year, 18,000 of the hip and 25,000 of the forearm, corresponding to a hip fracture incidence of 20.14/10,000, among the highest in the world. Government policy is implemented through several agencies, national and local. State of the art reports are currently available in 12 areas of musculoskeletal condition, including osteoarthritis, rheumatoid arthritis, osteoporosis, and hip fracture, while no national evidence-based guidelines have been developed for these conditions. The Swedish Council on Technology Assessment in Health Care provides the scientific foundation of present methods for treatment through evidence-based evaluations. National registers are continuously evaluating orthopedic implant procedures, of which the Swedish Hip Register has provided valuable information on total hip replacements since 1979. For the future, there is a need for setting of priorities with regard to musculoskeletal conditions, including development of guidelines of mechanism of implementation.
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PMID:Bone and joint diseases around the world. Sweden: a brief update on burden and priority. 1292 52

This randomized, prospective study compared 2 cemented hip stems that differed only in the surface finish, which was polished or grit blasted. A total of 226 hybrid total hips were evaluated at an average of 4.8 years postoperatively. No stem in either group was loose or revised for aseptic loosening. There was one case of significant distal lysis in the grit-blasted group. There was no statistical difference between polished and grit-blasted stems in incidence of lysis or bone-cement radiolucency. Harris Hip score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and SF-36 analysis showed no difference between groups. In conclusion, when adequate cement mantles are achieved around the femoral component, little difference in construct durability between polished and grit-blasted surface finish components can be detected at 4.8-year follow-up for this stem design.
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PMID:A prospective randomized trial of cemented femoral components with polished versus grit-blasted surface finish and identical stem geometry. 1456 Apr 17

Revision of a total knee arthroplasty may require an extensile approach to permit a satisfactory exposure without compromising the attachment of the patellar tendon. It has been assumed that a rectus snip is a relatively benign form of release, but the effect of using this approach on function, pain and patient satisfaction is not known. From January 1997 to December 1999, 107 patients who underwent revision of total knee arthroplasty were followed up at a minimum of two years (mean 40.5 months) and assessed by the Oxford Hip Score, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Short-Form (SF)-12 and patient satisfaction. Co-morbidity, surgical exposure, the Hospital for Special Surgery (HSS) knee scores and the range of movement were also used. A standard medial parapatellar approach was used in 57 patients and the rectus snip in 50. The two groups were equivalent for age, sex and co-morbidity scores. The WOMAC function, pain, stiffness and satisfaction scores demonstrated no statistical difference. The use of a rectus snip as an extensile procedure has no effect on outcome.
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PMID:The extensile rectus snip exposure in revision of total knee arthroplasty. 1465 91

Musculoskeletal conditions are a major burden on individuals, health systems, and social care systems, with indirect costs being predominant. This burden has been recognized by the United Nations and WHO, by endorsing the Bone and Joint Decade 2000-2010. This paper describes the burden of four major musculoskeletal conditions: osteoarthritis, rheumatoid arthritis, osteoporosis, and low back pain. Osteoarthritis, which is characterized by loss of joint cartilage that leads to pain and loss of function primarily in the knees and hips, affects 9.6% of men and 18% of women aged > 60 years. Increases in life expectancy and ageing populations are expected to make osteoarthritis the fourth leading cause of disability by the year 2020. Joint replacement surgery, where available, provides effective relief. Rheumatoid arthritis is an inflammatory condition that usually affects multiple joints. It affects 0.3-1.0% of the general population and is more prevalent among women and in developed countries. Persistent inflammation leads to joint destruction, but the disease can be controlled with drugs. The incidence may be on the decline, but the increase in the number of older people in some regions makes it difficult to estimate future prevalence. Osteoporosis, which is characterized by low bone mass and microarchitectural deterioration, is a major risk factor for fractures of the hip, vertebrae, and distal forearm. Hip fracture is the most detrimental fracture, being associated with 20% mortality and 50% permanent loss in function. Low back pain is the most prevalent of musculoskeletal conditions; it affects nearly everyone at some point in time and about 4-33% of the population at any given point. Cultural factors greatly influence the prevalence and prognosis of low back pain.
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PMID:Burden of major musculoskeletal conditions. 1471 May 6

Hip pain in young adults (18-35 years old) often is characterized by nonspecific symptoms, normal imaging studies, and vague findings from the history and physical examination. In younger patients, pain is more likely to be caused by congenital hip dysplasia, athletic injuries, trauma, spondyloarthropathy, and by conditions that first appear during this stage of life, such as rheumatoid arthritis, osteoarthritis, intravenous drug use, alcoholism, or corticosteroid use. The history and physical examination may narrow the diagnosis to intraarticular, extraarticular, or referred sources of pain. Plain radiography and magnetic resonance imaging are the preferred initial imaging procedures. Analyses of the blood, urine, and synovial fluid can be helpful in diagnosing inflammation, infection, and systematic rheumatic disease. Fractures, infection, and ischemic necrosis should be ruled out early because they require immediate treatment to prevent damage to the joint. Hip trauma at a young age increases the risk of osteoarthritis with advancing age, and, unlike most older adults, young adults receiving total hip replacement can expect revision surgery. Medical treatment often involves patient education, physical therapy, and pharmacotherapy. Acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids for pain and antibiotics for infection are the most often prescribed drugs for this population.
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PMID:The young adult with hip pain: diagnosis and medical treatment, circa 2004. 1504 86

This study was conducted to determine the effect of waiting times for total hip arthroplasty in terms of loss in quality-adjusted life years and additional burden perceived. A second goal was to study the effect of waiting times and preoperative function scores on postoperative outcome scores. Data were collected prospectively from a cohort of 161 patients waiting for total hip arthroplasty. The Oxford Hip score, Western Ontario and McMaster Universities Osteoarthritis Index, SF-36, and the EuroQol health status instruments were administered when the patient was placed on the waiting list, preoperatively, and 3 and 12 months after surgery. The disease-specific scores especially showed a significant deterioration during the waiting time. Moreover, a considerable loss of quality-adjusted life years occurred simply by postponing surgery. Although we found no direct effect of waiting time on postoperative outcomes, patients in a later phase of the disease process did not improve to the level achieved by patients with better preoperative function.
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PMID:Waiting for total hip arthroplasty: avoidable loss in quality time and preventable deterioration. 1506 41

Problems that occur in the hip joint, such as a loose body or labral tear, can be treated arthroscopically or with conventional arthrotomy. Hip arthroscopy can facilitate both comprehensive access to and treatment of an evolving series of conditions that affect the hip joint. Candidates for hip arthroscopy should have reproducible symptoms and physical findings that limit function, and a history of mechanical symptoms. Following total hip replacement, when unexplained symptoms persist despite appropriate conservative treatment combined with a negative workup, arthroscopy can be valuable. Intra-articular third bodies often can be successfully removed arthroscopically. Arthroscopy can be valuable after trauma for evacuation of hematomas and removal of chondral loose bodies, and repair of labral injuries. Contraindications to arthroscopy include advanced osteoarthritis, osteonecrosis with femoral head collapse, an ankylosed joint, significant protrusio or grade III or IV heterotopic bone.
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PMID:Hip arthroscopy: when it is and when it is not indicated. 1511 51

Implementation studies are recommended to assess the feasibility and effectiveness in real-life of programmes which have been tested in randomized controlled trials (RCTs). We report on an implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis (OA) of the knee or hip. Three types of primary health-care providers (n = 18) delivered the OA Knee programme (n = 20) and the OA Hip programme (n = 20), supported by programme manuals and implementation guidelines, in four regions. The outcome measures were pain and mobility. The Knee programme had OA knowledge and self-efficacy as additional outcome measures. Differences in outcome measures and background variables of participants were assessed between the RCTs and the implementation study. Positive effects (P < 0.05) were found for OA knowledge, pain and self-efficacy in the Knee programme (n = 157), and for pain in the Hip programme (n = 132). No effect was found for mobility. Effect sizes of the RCTs and the present study were comparable. Background variables did not explain the variance in the outcome measures. The outcomes of the previous RCTs and the implementation study were comparable, and indicated the ecological validity of the two programmes. The implications for nationwide dissemination and implementation in The Netherlands are discussed.
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PMID:An implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis of the knee and hip. 1514 Aug 51

Twenty-four hips (23 patients) underwent isolated polyethylene liner exchange (modular and nonmodular liners) via the direct lateral surgical approach for a preoperative diagnosis of polyethylene wear and acetabular osteolysis. Accessible osteolytic lesions were bone grafted with cancellous allograft. Patients were followed up clinically and radiographically, with a mean follow-up time of 36 months (range, 12-100 months). A computer-assisted method measured lesional area from the radiographs of the 18 hips that presented with osteolysis. Seventeen of 18 lesions either regressed or resolved since the procedure. Two patients required repeat revisions, and no dislocations were noted. Clinically, both Harris Hip and Western Ontario and McMaster Universities Osteoarthritis Index scores improved postoperatively. In selected patients, isolated liner exchange with or without bone grafting is effective for treating polyethylene wear and associated osteolysis. Dislocation rates with revision may be reduced using a surgical approach that preserves an adequate capsular layer for closure in liner exchange surgery.
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PMID:Isolated liner exchange in revision total hip arthroplasty: clinical results using the direct lateral surgical approach. 1518 98


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