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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diagnosis of avascular necrosis in the early stages (I and II) offers the opportunity to prevent late segmental collapse and secondary degenerative arthritis of the hip through early surgical intervention. Functional bone marrow studies and core biopsy are the simplest and best tests for diagnosing avascular necrosis of the hip. Bone scans are helpful in diagnosis and provide supportive evidence. Routine roentgenography and occasionally tomography are the only tests required for diagnosis in advanced stages of the disease.
Hip 1983
PMID:Avascular necrosis of the femoral head--diagnostic techniques, reliability and relevance. 667 15

Hip involvement is unusual in patients with hemophilia. Radiographic findings range from soft-tissue swelling and growth abnormalities to cartilage damage and osteoarthritis. Two patients are presented in whom severe bone resorption followed these more usual findings.
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PMID:Resorptive hip arthropathy in hemophilia. 707 9

Although surface replacement hip arthroplasty has been viewed by some as a conservative alternative to conventional total hip arthroplasty, the surgical technique requires substantially more acetabular bone loss. To evaluate the efficacy of this operation, a retrospective study of 74 consecutive cases of surface replacement hip arthroplasty done at the University of California, San Francisco between February 1977 and June 1980 is reported and concludes that (1) there was no noteworthy difference in end result between cases using the Indiana, THARIES, or Freeman prostheses; (2) although there were major improvements in pain, function, and range of motion, unexplained pain persisted in 51.6% of cases; (3) the failure rate of 33.8% in the first 3 years was higher than that reported for conventional total hip arthroplasty; and (4) hips with a history of trauma failed the most frequently and showed the least improvement, whereas hips with osteoarthritis showed the fewest failures and the best results. We conclude that surface replacement hip arthroplasty is not superior to conventional total hip arthroplasty, judged by the criteria of pain relief, improvement of function, and failure rate.
Hip 1982
PMID:Surface replacement hip arthroplasty: results of the first seventy-four consecutive cases at the University of California, San Francisco. 716 97

Hip dysplasia is a common developmental problem affecting the canine population. Despite extensive research into the condition, many questions remain unanswered and numerous misconceptions are present among the general public. The purpose of this paper is to review the current knowledge on the development of hip dysplasia, factors modifying its development, and current diagnostic techniques.A computerized literature search was conducted for the period of January 1983 to April 1985 using the MEDLINE and CAB databases, and the keywords hip dysplasia, hip, dog, and canine. Other articles,wherever possible original research articles, published before 1983 were also reviewed. Animals affected by hip dysplasia are born with normal hips, but quickly develop subluxation of the femoral head. Degenerative joint disease follows. Hip dysplasia is a complex, inherited, polygenic trait. Selective breeding of only normal dogs with normal littermates, parents, and grandparents is there commended method of reducing the incidence in the general population.Gene expression in affected individuals may be modified by a number of environmental factors. These factors do not cause hip dysplasia, but they alter manifestations of the trait and its severity. Nutrition is a major environmental factor. Excess energy consumption increases the frequency and severity of hip dysplasia in genetically predisposed dogs. Food intake should be regulated to maintain a slender figure with the ribs and dorsal vertebral spines easily palpable, but not visible. Excess dietary calcium and vitamin D contribute to hip dysplasia in genetically predisposed individuals and should be avoided. High dose vitamin C supplementation ingrowing puppies does not prevent hip dysplasia, and this practice should be discontinued. Animals must be 2 years old before they can be certified as normal, but the disease may be diagnosed earlier. Earlier diagnosis of the condition would be very useful for the selection of breeding stock, but palpation techniques and the standard extended view radiographs have unacceptably high rates of error in young puppies. Stress radiography techniques may improve the accuracy of early diagnosis in the future.
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PMID:The pathogenesis and diagnosis of canine hip dysplasia: a review. 758 36

New cross-sectional studies have been designed to evaluate therapeutic effectiveness of medical and surgical treatments. The extent to which error in recollection may threaten the validity of conclusions reached in these studies has not been determined. The purpose of this research was to evaluate the impact of recollection error by comparing patients' prospectively acquired reports about their condition before total hip replacement with their recollections of their preoperative condition obtained several years after surgery. A total of 104 patients prospectively completed the Hip Rating Questionnaire (HRQ), a valid, reproducible, responsive, disease-specific scale composed of four domains (pain, walking, function, and impact of hip arthritis on overall health). These same patients then completed the HRQ several years after surgery by recalling their preoperative condition. Current postoperative condition was also obtained several years after surgery with the HRQ. Patient characteristics include: 55% were women, mean age was 67 years, 90% had osteoarthritis, 78% had no prognostically significant comorbid disease, and the mean time interval between surgery and recall was 2.5 years. Comparison of prospective and recalled responses with the weighted kappa and intraclass correlation coefficients showed poor to fair agreement in three domains, and moderate agreement in the fourth domain. Overall, the directions of the recollection errors were toward patients' recalling more pain, better walking, better function, and worse impact of hip arthritis on health than they reported before surgery. When the data were stratified to determine if there were systematic biases among major patient subgroups, there were discrepancies in the percentage of patients within each subgroup who had recollection error for the different domains, as well as differences in the magnitudes and directions of the recollection errors. These results indicate that relying on patients' recollections does not provide an accurate measure of preoperative state, and that attempting to adjust data is not feasible because the directions and magnitudes of recollection error vary for major subgroups of patients. In addition, when outcome was assessed using postoperative HRQ responses, the cross-sectional data overestimated the effectiveness of total hip replacement in 68% of patients. It is concluded that cross-sectional data do not accurately portray baseline preintervention condition and therefore can lead to overestimating, as in this instance, or to underestimating effectiveness.
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PMID:Does recollection error threaten the validity of cross-sectional studies of effectiveness? 772 63

The purpose of this study was to investigate the relationship between clinical symptoms, static radiographic measurements, and of load distribution during walking at the knee, in 54 patients with moderate medial osteoarthrosis of the knee. Varus deformity of the knee was assessed from static radiographic measurements as the Hip-Knee-Ankle (HKA) angle, and range of moments at the knee in the frontal plane were assessed using a Kistler force plate system. No correlations between clinical symptoms and radiographic parameters or moments at the knee were found. The adduction moment in mid stance was more important than the peak adduction moment in differentiating between patients and normal controls. The amplitude of the peak adduction moment depended on the sex and body mass of the patients, while the amplitude of the mid stance adduction moment depended on body mass and the varus deformity of the knee. There was a weak correlation between the peak adduction moment and the HKA-angle (r = 0.32, P < 0.05) and there was a moderately high correlation between the peak adduction moment in mid stance, i.e 50% of the stance phase, and the HKA angle (r = 0.46, P < 0.001) even after normalization of the mid stance moment to body mass. Accordingly, 20% of the medio-lateral knee load in mid stance during walking could be explained by the varus deformity of the osteoarthrotic knee in our patients.
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PMID:Adduction moment of the knee compared to radiological and clinical parameters in moderate medical osteoarthrosis of the knee. 785 69

This study was based on the unexpected observation of lateral patellofemoral subluxation in the varus osteoarthritic knee. Standardized radiographs of 109 knees (65 patients with osteoarthritis) were selected randomly from the authors' database and retrospectively reviewed. Hip-knee-ankle alignment data were correlated with patellofemoral subluxation and tilt, as well as with radiographic patellofemoral grades for arthrosis. The amount and site of patellofemoral arthrosis were correlated with patellar position and limb alignment. Patellae that were located centrally in the trochlear groove had the lowest radiographic score for arthrosis. Subluxation of the patella, either medially or laterally, was correlated with increased radiographic scores. Limb alignment was not correlated with the radiographic score. A significant percentage of varus knees (28%) had unexpected lateral subluxation of the patella. This observation has not been reported previously. It may have an impact on surgical decision-making for total knee arthroplasty and osteotomy.
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PMID:Patterns of knee arthrosis and patellar subluxation. 799 77

One hundred and two uncemented total hip arthroplasties using an anatomic femoral component were performed and followed postoperatively in 96 patients for an average of 35 months (range 24-44). Clinical assessment was performed by a Harris Hip Score (HHS) and standardized radiographs. The primary diagnoses were: osteoarthritis, 86 patients; traumatic arthritis 2; inflammatory arthritis 2; congenital hip dysplasia 5 and avascular necrosis 1. There were 44 males and 52 females. The purpose of this study was to prospectively study whether anatomically designed cementless femoral stems reduce the incidence of thigh pain and limp in the early period after total hip arthroplasty. The average pre-operative HHS was 47, the average pain score was 16 and average function score 25. At the last follow-up the average HHS was 93, average pain and limp at one year was 3.5% and was only slight to mild; this decreased to 1.9% at last follow-up. Radiographic findings included calcar rounding 75%, pedestal formation 40%, distal cortical hypertrophy 20% and incomplete radiolucencies in 35%. No endosteal erosions were seen. Heterotopic ossifications were present in 2 patients, one of which required excision. Complications consisted of dislocations treated closed, 3 intra-operative fractures without sequellae, 1 traumatic peri-operative fracture which required surgery without further complication and 1 pulmonary embolism. One patient required revision for leg length discrepancy. There were no infections. The results of this study indicate that this cementless, anatomically designed femoral component can provide satisfactory, early pain relief and function in this younger, active patient population.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Anatomic cementless total hip replacement: design considerations and early clinical experience. 811 96

Factors associated with hip osteoarthritis were studied in 2,490 subjects aged 55-74 years using data from the First National Health and Nutrition Examination Survey (NHANES-I). Pelvic radiographs were read for hip osteoarthritis using Kellgren-Lawrence scales; cases were defined by grade > or = 2 changes. Subjects with missing radiographs and other data and those with grade 1 radiographic changes (n = 132) were excluded from analyses. Crude and adjusted odds ratios and 95% confidence intervals (CIs) were estimated from logistic regression analyses. Overall, the crude prevalence of hip osteoarthritis was 3.1% (73 of 2,358); 42 cases were unilateral, and 31 cases were bilateral. Age was significantly associated with hip osteoarthritis (adjusted odds ratios = 1.30 (95% CI 0.60-2.81), 1.69 (95% CI 0.83-3.44), and 2.38 (95% CI 1.15-4.92) for ages 60-64, 65-69, and 70-74, respectively). Other sociodemographic factors, obesity, and fat distribution were not associated with hip osteoarthritis. Age and hip trauma were strongly associated with hip osteoarthritis among men; however, among women, no factors were significantly associated with hip osteoarthritis. Hip trauma was significantly associated with unilateral but not bilateral hip osteoarthritis, while obesity was associated with bilateral but not unilateral hip osteoarthritis. These data suggest that etiologic factors associated with hip osteoarthritis may differ for males and females and for unilateral and bilateral hip osteoarthritis.
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PMID:Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). 831 37

Between March 13, 1984 and March 28, 1988, 233 patients (age range from 21 to 73 years) with osteoarthritis of one or both hips were treated with the uncemented hip replacement "Erlanger Modell" (Prof. H. Beck/P. Brehm Chirurgie-Mechanik GmbH). The cause of the osteoarthritis was variable. Hip replacement was carried out for the following conditions: rheumatoid arthritis including ankylosing spondylits (n = 29), aseptic necrosis of the femoral head including posttraumatic and idiopathic forms (n = 17), osteoarthritis of unknown origin (n = 111), osteoarthritis following dysplasia or subluxation of the hips (n = 56) and loosened cemented hip prostheses (n = 37). Full weight bearing was not permitted for 50 days postoperatively, but mobilization and isometric exercises began 2 days after operation and isotonic exercises are introduced later. Complications included fracture of the femoral shaft during operation (3.3%), fracture of the femoral shaft postoperative (1.6%), dislocation (0.8) and infection early after operation (0.4%) and aseptic loosening (3.7%). Our results of 233 patients (250 joints), ranging from 4 to 8 postoperative years giving an average of 5.3 years, are encouraging. Good results based on patients satisfaction were obtained in 95.2% (83.8% after revision) and poor results in 1.0% (2.7% after revision). 3.8% (13.5 after revision) judged their situation as unchanged. 93.3% of the patients can walk without hooked stick (53.3% after revision), 90.2% of the patients can walk more than 1000m (69.4% after revision).
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PMID:[Eight years experience with the "Erlangen Model" titanium prosthesis--results of cementless implantation of 250 hip prostheses]. 834 43


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