Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients were evaluated for a complaint of long-standing hip pain. No etiology of their progressively disabling symptoms was found by routine diagnostic studies. Hip arthrography and arthrotomography in each case, however, demonstrated multiple intraarticular filling defects consistent with nonradiopaque loose bodies. These were subsequently confirmed at arthrotomy. Synovial chondromatosis is a rare disease in which intrasynovial cartilage metaplasia results in multiple intracapsular loose bodies. Its presence in plain radiographs is uncommon, but has been previously documented. This can account for frequent long delays in accurate diagnosis. Arthrography and/or arthrotomography, however, can be key diagnostic tools. They are recommended in the evaluation of patients whose relatively normal initial clinical examination, laboratory, and roentgenographic studies fail to adequately explain the presence of genuinely disabling symptoms.
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PMID:Synovial chondromatosis. 342 42

Synovial chondromatosis is a rare condition of metaplastic cartilage development in the synovial membrane of joints. These foci can form free bodies and lead to mechanical arthrosis. The precise etiology is unknown. All synovial joints can be affected, with the hip and knee being most common. Patients with synovial chondromatosis are usually in their fifth decade and typically present with mechanical pain and diffuse swelling. Due to its rarity and nonspecific manifestations, diagnosis of synovial chondromatosis is often delayed until significant mechanical damage and arthrosis has occurred.Controversy exists regarding surgical treatment of synovial chondromatosis, especially with regard to the hip. Localized disease can be treated with resection of affected synovium (possibly arthroscopically), whereas patients with generalized disease require complete, open synovectomy. With articular damage, total hip replacement has been advocated along with synovectomy.This article presents a case of a young man with painful hip synovial chondromatosis who was successfully treated with hip resurfacing and synovectomy after failed hip arthroscopy. Hip resurfacing provides the surgeon with the opportunity to address not only local or generalized synovial disease, but articular damage as well. Furthermore, its bone-preserving properties make this option attractive in the management of this younger patient population. We feel resurfacing has a role in the surgical treatment of synovial chondromatosis. To our knowledge, this is the first case of hip resurfacing arthroplasty for the definitive treatment of synovial chondromatosis.
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PMID:Hip resurfacing as treatment for synovial chondromatosis. 2034 74

Synovial chondromatosis (SC) is a rare benign disorder of unknown aetiology resulting in multiple cartilaginous loose bodies that form within a synovial joint. It is predominantly seen in men (2:1) in the third and fifth decade of life and is extremely rare in children. Hip joint is an extremely rare and unusual site of presentation thus leading to delay in diagnosis and associated morbidity. We report a successfully treated case of SC in a 12-year-old girl complaining of hip pain over a year. In addition, this is also the first case of a child with SC of the hip being treated arthroscopically.
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PMID:Rare cause of hip pain in a young girl. 2481