Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50502 (
Hip
)
7,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
HspBP1
was originally identified and characterized as a novel Hsp70/
Hsc70-interacting protein
that inhibited the Hsp70/Hsc70 chaperone activity. In this respect, Hsps have been shown to influence cell-death pathway through the interaction with key components of the apoptotic machinery. In this report, we have examined the effect of
HspBP1
overexpression on the sensitivity of tumor cells to anticancer drug-induced apoptotic response. Analysis with
HspBP1
deletion mutant genes showed that C-terminus 47 amino acid residues were essential for the specific interaction of
HspBP1
with Hsp70/Hsc70. Overexpression of
HspBP1
induced enhanced apoptotic response against anticancer drugs, but
HspBP1
lacking C-terminus 47 amino acid residues did not. These results support the notion that inhibition of the function of Hsp70 enhances the therapeutic efficacy of chemotherapy.
...
PMID:[Heat shock protein 70 binding protein 1 induces enhanced apoptotic response against anticancer drugs in tumor cells]. 1528 46
