Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proximal femoral focal deficiency, a distinct clinical and radiographic entity that results in leg length discrepancy, has received little attention in the radiographic literature. Thirteen patients were studied and the degree of deficiency established using radiographic criteria. The full extent of hip instability often could not be ascertained on radiographs obtained during the first year of life. Hip arthrograms combined with cine radiography can establish the presence of an unossified femoral head and aid in evaluating the degree of hip instability. Unlike other causes of leg length discrepancy, such as congenital idiopathic coxa vara, proximal femoral focal deficiency is often associated with other congenital bony anomalies, most commonly ipsilateral absent or hypoplastic fibula.
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PMID:Proximal femoral focal deficiency. 9 10

Antiontensin-converting enzyme (peptidyldipeptide hydrolase, EC 3.4.15.1) has been solubilized from canine pulmonary particles and purified to apparent homogeneity. A value of approx. 140000 was estimated for the molecular weight of the native and the reduced, denatured forms of the enzyme. No free NH2-terminal residue was detected by the dansylation procedure. Carbohydrate accounted for 17% of the weight of the enzyme, and the major residues were galactose, mannose and N-acetylglucosamine with smaller amounts of sialic acid and fucose. Removal of sialic acid residues with neuraminidase did not alter enzymatic activity. The enzyme contained one molar equivalent of zinc. Addition of this metal reversed stimulation and inhibition of activity observed in the presence of Co2+ and Mn2+, respectively. Immunologic homology of pure dog and rabbit enzymes was demonstrable with goat antisera. Fab fragments and intact IgG antibodies displayed similar inhibition dose vs. response curves with homologous enzyme, whereas the fragments were poor inhibitors of heterologous activity compared to the holoantibodies. The canine glycoprotein was much less active than the rabbit preparation in catalyzing hydrolysis of Hip-His-Leu. In contrast, the two enzymes exhibited comparable kinetic parameters with angiotensin I as substrate.
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PMID:Canine pulmonary angiotensin-converting enzyme. Physicochemical, catalytic and immunological properties. 20 22

ACE activity of the serum of 52 normal pregnant women was measured in vitro under conditions of substrate saturation with Hip-His-Leu as substrate. The product His-Leu was measured by fluorimetry after reaction with o-phthaldehyde. ACE activity (nmol/min/ml serum) was 30.6 +/- 7.8, 28.8 +/- 7.4, and 30.9 +/- 8.2 for the first, second, and third trimester of pregnancy, respectively. No statistically significant differences (p greater than 0.05) in ACE activity were detected among the three trimesters of normal pregnancy with either serum volume or serum protein as reference value. These values are within the range reported by Friedland and Silverstein13 for 51 male and seven female healthy blood bank donors. We conclude that the evolution of normal pregnancy does not significantly modify the levels of ACE in peripheral blood serum.
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PMID:Angiotensin-converting enzyme: serum levels during normal pregnancy. 22 54

Aseptic necrosis developed in 11 (6%) of 171 recipients of renal allografts who underwent transplant operations at Childrens Hospital of Los Angeles between February 1967 and August 1977. Pain was the predominant presenting symptom and preceded roentgenographic evidence of aseptic necrosis by as long as seven months. Initial symptoms occurred two months to four years posttransplant. Limited weight bearing and reduction in the dosage of prednisone failed to prevent the progressive destruction of five femoral heads in three patients. Hip replacement led to an amelioration of the symptoms and a resumption of normal activity in each patient. Two patients with involvement of multiple osseous structures have persistent knee and elbow joint pain and effusions, and one of them has required prosthetic replacement of the proximal humerus. No therapy was required for patients with aseptic necrosis of single bones of the hand and foot. There was no statistically significant difference in the total steroid dose received during the first posttransplant year between patients in whom aseptic necrosis developed, and those in whom it did not develop.
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PMID:Aseptic necrosis after renal transplantation in children. 35 87

1. The activity of slowly adapting joint receptors was recorded from fibers of the posterior articular nerve of the hip in deeply anesthetized cats. The static stimulus was any position of the femur maintained at least 2 min after passive displacement. Most of the fibers are active in all the positions where the femur may be placed. Modulation in the discharge frequency occurs in any axis of displacement, and higher activity is recorded at extreme positions. The maximal discharge may be reached in several positions of the femur far away from one another. 2. Adaptation to static stimuli occurs in all the receptors. Joint receptors fire at very regular, steady rates; the mean coefficient of variation was 0.079. 3. In most of the receptors, when the femur is displaced along a single axis, the frequency of discharge varies as a monotonic function of joint position. This relationship could be described either by linear and logarithmic or by linear and power functions, according to the criteria adopted to indicate the intensity of the stimulus. 4. Repetition of identical static stimuli results in different responses. 5. The static properties of the receptors are not modified by the section of periarticular muscles. 6. Hip joint receptors are able to code hip joint position.
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PMID:Slowly adapting receptors in cat hip joint. 43 Jan 18

In a series of 57 hemiplegic patients who subsequently fractured their hips, it was found that hip fracture occurred significantly more often on the hemiplegic side. Hip fracture was equally common in right- and left-sided hemiplegia, and often occurred within one year of the stroke. Two factors seem to be important in the genesis of hip fractures in hemiplegic patients: the tendency of stroke patients to fall to the affected side as a result of impaired locomotor function, and the development of disuse osteoporosis in the hemiplegic limb.
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PMID:Hip fracture after hemiplegia. 47 62

This study describes the orthopedic treatment and utilization of health care obtained by 2,333 patients in the population of Rochester, Minnesota, who suffered 2,519 limb fractures during the period 1969 through 1971. Overall, 24% of fracture occurrences required patient hospitalization, the remainder involving care on an ambulatory basis only. The mean number of physician visits was 4.5 per fracture, with the visits occurring during an interval of 103 days from the time of first evaluation. Fifteen percent of limb fractures were subject to at least one surgical operative procedure as part of their orthopedic treatment. The frequency of operative treatment increased markedly with patient age. Seventeen percent of patients with limb fractures received physiotherapy or occupational therapy or both, 4% were ambulatory patients, and the remainder were hospital inpatients. Fractures of the head and neck of the femur constituted only about 7% of fractures in the series, yet utilized an inordinate proportion of health care resources. Hip fractures were responsible for 27% of the hospital admissions, 52% of all bed days utilized, and 56% of the physiotherapy sessions.
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PMID:Limb fractures in a defined population. II. Orthopedic treatment and utilization of health care. 49 62

We performed double innominate osteotomy in twenty-five patients with acetabular insufficiency resulting from congenital dislocation of the hip and other lesions. Following iliac (Salter) osteotomy, the second osteotomy was carried out medial to the obturator foramen in the interval between the symphysis pubis and the pubic tubercle. In children more than six years old, adolescents, and adults, addition of the pubic osteotomy increased the amount of acetabular rotation and coverage of the femoral head that could be achieved. An additional benefit was that the femoral head could be shifted medially, decreasing the length of the femoral lever arm. The improvement in center-edge angle in the twenty-five patients averaged 27 degrees, and the acetabular index decreased an average of 19.5 degrees. The center of the head shifted medially an average of 1.5 centimeters. Hip stability was achieved in twenty-three of the patients.
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PMID:Double innominate osteotomy. 59 40

Body density, total body volume, leg volume and arm volume of 65 young Indian women 20-25 years were measured experimentally. In addition, a series of 61 anthropometric measurements were also taken on each subject. Correlations of leg volume with total body volume and body density were 0.91 and -0.73 respectively and of arm volume with total body volume and body density were 0.84 and -0.66 respectively. Hip girth alone showed a very high positive correlation (r = 0.94) with body volume and on selective stepwise multiple regression analysis, a combination of even four anthropometric measurements, namely, hip girth, lower thigh girth, ankle girth and shoulder diameter gave an extremely high positive multiple correlation coefficient (R = 0.98) with body volume. Selective stepwise multiple linear regression analysis was conducted also to estimate leg volume, arm volume and body density and stepwise regression equations up to 4th step for estimating each parameter are given.
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PMID:Anthropometric determination of body volume, body density and segmental volume in adult Indian women. 59 21

Clinical, laboratory, and radiological investigation of 6 cases of idiopathic monoarticular adult hip synovitis demonstrates that unlike the syndrome in children, in the adult the onset is very acute, short in duration, and followed by a short tapering off period with no sequelae to date. The ESR is the best index of the severity and course of the illness. Hip aspiration is of diagnostic value. Viral etiology was suspected, but not proven. Recognition of this syndrome in the adult will prevent an unnecessary arthrotomy for "septic arthritis" of the hip joint.
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PMID:Transient monoarticular synovitis of the hip joint in adults. 59 15


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