Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P47989 (xanthine oxidase)
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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
xanthine oxidase 8633
superoxide dismutase 1695
catalase 1335
Sep 624
xanthine dehydrogenase 403
glutathione peroxidase 385
Mol 334
GSH 308
SOD 279
nitric oxide synthase 277
NADPH 275
ATP 254
NADH 249
myeloperoxidase 235
cytochrome c 216
Superoxide dismutase 191
lactate dehydrogenase 188
aldehyde oxidase 180
cyclooxygenase 167
peroxidase 162
microsomal 153
Catalase 141
NAD 140
tumor necrosis factor 125
glutathione reductase 122
lipoxygenase 120
NMR 120
adenosine deaminase 118
lipopolysaccharide 118
albumin 113
xanthine oxidoreductase 111
ROS 110
ADP 108
inducible nitric oxide synthase 99
ATPase 98
insulin 96
EPR 92
cytochrome P450 91
TNF 86
cytokine 85
FAD 84
reductase 83
antioxidant enzyme 73
AMP 73
collagen 71
caspase-3 69
cytochrome P-450 67
ESR 65
serum albumin 65
cytochrome 63
hemoglobin 63
alkaline phosphatase 60
XDH 58
purine nucleoside phosphorylase 57
aspartate aminotransferase 56
oxidoreductase 56
NOT 55
NAD+ 55
gut 54
angiotensin II 51
IL-6 51
MnSOD 51
endothelial nitric oxide synthase 50
glucose-6-phosphate dehydrogenase 49
thymus 48
p38 47
tyrosinase 47
vascular endothelium 46
TNF-alpha 46
spermatozoa 46
ornithine decarboxylase 46
heme oxygenase-1 45
phospholipase A2 45
ferritin 45
endoplasmic reticulum 44
sulfite oxidase 43
CO2 43
amylase 43
glutathione S-transferase 41
alanine aminotransferase 41
flavoprotein 41
SDS 38
aldehyde dehydrogenase 38
creatine kinase 37
manganese superoxide dismutase 36
hypoxanthine-guanine phosphoribosyltransferase 35
SIN 35
Bcl-2 34
eNOS 34
LPS 33
5'-nucleotidase 32
alcohol dehydrogenase 32
MAPK 32
bradykinin 32
polypeptide 32
glucosidase 32
interleukin-6 31
casein 31
Pseudomonas 31
CYP1A2 30
interferon-gamma 29
guanylate cyclase 28
ESI 28
endothelin-1 28
P450 27
COX-2 27
lactoperoxidase 27
renin 27
CAT 27
nucleoside phosphorylase 26
GTP 26
mast cell 26
LDH 25
matrix metalloproteinase 25
p47 25
membrane-bound 25
IMP 25
xenobiotic 25
metallothionein 25
NADPH-cytochrome P-450 reductase 24
DT-diaphorase 24
NADP 24
NMDA receptor 24
myoglobin 23
ERK1 23
PEG 23
transferrin 23
cyclooxygenase-2 23
interferon 22
N-acetyltransferase 22
acetylcholinesterase 22
butyrophilin 22
Gen 22
P-selectin 21
urate transporter 1 21
Ang II 21
Myeloperoxidase 21
5-lipoxygenase 20
lipase 20
ceruloplasmin 20
gamma-glutamyl transpeptidase 20
IL-1 20
C-reactive protein 20
p53 20
PKC 20
glycoprotein 20
NLRP3 20
phosphodiesterase 19
IL-10 19
mitogen-activated protein 19
ICAM-1 19
SOD1 19
ERK 19
lactoferrin 19
p65 19
NADH dehydrogenase 18
glucose transporter 18
CPR 18
thrombin 18
collagenase 18
more...
Disease
ischemia 695
gout 380
hyperuricemia 365
GSH 308
cancer 274
diabetes 191
hypertension 189
tumor 177
atherosclerosis 137
heart failure 98
arthritis 89
cardiovascular disease 81
depression 79
myocardial ischemia 76
carcinogenesis 74
myocardial infarction 59
renal disease 57
NAME 56
stroke 53
obesity 52
cerebral ischemia 50
sepsis 46
cold 45
sepsis 44
hyperglycemia 43
metabolic syndrome 42
hypercholesterolemia 40
Alzheimer's disease 39
acute pancreatitis 38
SDS 38
carcinoma 37
type 2 diabetes 33
pulmonary edema 32
renal ischemia 32
SEM 32
pancreatitis 31
hepatocellular carcinoma 28
tophi 26
renal failure 26
pulmonary hypertension 24
vascular disease 24
leukemia 24
plaque 22
acute myocardial infarction 22
preeclampsia 22
rheumatoid arthritis 21
hepatitis 21
adult respiratory distress syndrome 20
urolithiasis 20
hyperlipidemia 20
asthma 19
mole 19
acute renal failure 19
proteinuria 19
melanoma 19
breast cancer 19
immunodeficiency 19
mole 19
renal impairment 19
influenza 18
Parkinson's disease 18
coronary artery disease 18
congestive heart failure 18
malaria 17
chronic granulomatous disease 16
renal insufficiency 15
tumorigenesis 15
inflammatory bowel disease 14
virus infection 14
tumor lysis syndrome 14
MCF 14
HIV 14
prostate cancer 14
rheumatism 14
ulcerative colitis 13
diabetic nephropathy 13
colitis 13
metabolic disorder 13
ventricular fibrillation 13
tuberculosis 13
Endothelial dysfunction 12
fatty liver 12
Mycobacterium 12
tumor growth 12
glomerulosclerosis 12
dementia 12
coronary heart disease 12
Evans 12
cirrhosis 12
worms 12
Lesch-Nyhan syndrome 11
chronic obstructive pulmonary disease 11
sickle cell disease 11
cardiomyopathy 11
multiple sclerosis 11
celiac disease 11
West 11
liver disease 11
acute promyelocytic leukemia 10
colorectal cancer 10
infectious diseases 10
heart disease 10
epilepsy 10
iron overload 10
cystic fibrosis 10
coronary occlusion 9
cornea 9
nephrolithiasis 9
fits 9
lymphoma 9
Placenta 9
gastric ulcer 9
ATM 9
neuroblastoma 9
nephrosis 9
brain edema 9
ADA deficiency 9
ventricular hypertrophy 9
cataract 9
dehydration 9
osteoarthritis 8
Infection 8
dyslipidemia 8
Chagas 8
acute lymphoblastic leukemia 8
solid tumor 8
anemia 8
necrotizing enterocolitis 8
essential hypertension 8
bacterial infection 8
diabetic retinopathy 8
Blocking 8
amyotrophic lateral sclerosis 8
neutropenia 8
glucose intolerance 8
premenstrual syndrome 8
Pineal 8
pheochromocytoma 8
cholestasis 8
adenocarcinoma 8
SAR 8
PMS 8
alcoholic fatty liver 7
leukopenia 7
infertility 7
Schistosoma mansoni 7
Crohn's disease 7
liver fibrosis 7
bladder cancer 7
APRT deficiency 7
skin tumor 7
dermatitis 7
chronic renal failure 7
colon cancer 7
rash 7
PAPA 7
mastitis 7
pertussis 7
Gouty arthritis 7
hepatitis B 7
more...
Symptom
hyperoxia 30
anesthesia 26
pain 24
seizures 18
fatigue 16
functional recovery 13
angina 12
diarrhea 12
exhaustion 12
respiratory distress 11
hypothermia 10
starvation 10
skin damage 7
acidity 6
collapse 5
nausea 5
vomiting 5
weakness 5
erythema 5
headache 5
hypercapnia 3
overweight 3
oliguria 3
arthralgia 3
Anoxia 3
dizziness 3
myalgia 3
cachexia 3
Ill 2
hypocapnia 2
flushing 2
discomfort 2
anorexia 2
discomfort 2
twitching 2
chest pain 2
abdominal pain 2
colic 2
agitation 2
autodigestion 2
dry eye 2
acute stress 2
thinning 2
memory loss 1
skin irritation 1
pelvic pain 1
polyuria 1
tonic-clonic seizure 1
asthenia 1
hypertonia 1
hypotonia 1
renal colic 1
prostration 1
muscle rigidity 1
hepatosplenomegaly 1
exertional dyspnea 1
leg edema 1
athetosis 1
HSA 1
neuralgia 1
paresis 1
eds 1
No adverse effect 1
spasm 1
rigors 1
catarrh 1
ketonuria 1
disturbed balance 1
sleepiness 1
throat irritation 1
Macula 1
hyperesthesia 1
dystonia 1
Drug
NADH 247
ascorbate 213
vitamin E 135
ROS 110
FAD 84
Cardiovasc 84
Febuxostat 76
caffeine 71
Indomethacin 33
Dermatol 32
NBT 32
Ethanol 27
lysine 26
Glutathione 24
Vitamin E 19
nitroglycerin 17
IFN-gamma 15
Adriamycin 15
Desferal 14
Desferal 14
FeCl3 14
Rasburicase 13
Albumin 12
Mutagen 11
CaCl2 10
CaCl2 10
CaCl2 10
Nitric Oxide 10
Gel 10
Ringer's solution 9
Methylene blue 9
CSF 9
L-tyrosine 9
Adenosine deaminase 9
Angiotensin II 8
IL-2 8
Leaf 8
Monit 8
Nephron 8
MAP 7
Vitamin K 7
balanced salt solution 7
Acacia 7
Y-700 7
Photofrin 6
Myricetin 6
Sodium nitroprusside 6
Spectrum 6
Captopril 6
Propofol 6
Nephron 6
Fructose 6
Rasburicase 5
Cimetidine 5
NH3 5
Rebamipide 5
BH4 5
Fluorescein 5
pyridoxal phosphate 5
Arsenic trioxide 5
Rutin 5
Cimetidine 5
Glycyrrhiza 5
Ouabain 4
Heme 4
CTX 4
Histamine 4
ZnO 4
Omeprazole 4
Aloe 4
CAM 4
ETA 4
DNase I 4
TMX 4
TiO2 3
MgSO4 3
Ginseng 3
Zinc sulfate 3
Riboflavin 3
Carotenoid 3
SiO2 3
Fraction 3
Iloprost 3
ICI 3
Sesame oil 3
Moco 3
THF 3
niacin 3
APD 3
Portal 3
Dial 3
Zinc sulfate 3
Malonaldehyde 3
EPA 2
NAG 2
ABC 2
ENT 2
Lodoxamide tromethamine 2
Capsicum 2
Atractylodes rhizome 2
Acyclovir 2
ddI 2
Retinoic acid 2
FCV 2
Asn 2
CoCl2 2
CoCl2 2
Triclosan 2
Tirapazamine 2
Rosuvastatin 2
Ginger 2
Sesamol 2
RAL 2
Adenosine triphosphate 2
Phosphatidylserine 2
PTH 2
Silica gel 2
Pirfenidone 2
Scutellaria root 2
Silica 2
Lovastatin 2
ALA 2
Meth 2
Sucralfate 2
citric acid 2
Tantum 2
all-trans-retinol 2
Ketotifen 2
Cellulose acetate 2
Gastro 2
Troglitazone 2
Vitamin B 1
Diphenhydramine 1
Asthma 1
Amflutizole 1
7,8-Dihydroneopterin 1
NaI 1
Nilvadipine 1
Zovirax 1
Lisofylline 1
Trifluoperazine 1
Nebivolol 1
Piracetam 1
SNL 1
Vena 1
C3H6 1
Indapamide 1
Valsartan 1
DMSA 1
Vitamin K2 1
Dezaguanine 1
Biopolymers 1
Doxycycline 1
EE2 1
Pyridoxal 1
Caraway 1
Gelatin 1
Compound 19 1
Troxipide 1
Lead acetate 1
more...
Enzyme
xanthine oxidase 7867
superoxide dismutase 1868
catalase 1347
xanthine dehydrogenase 459
NADPH oxidase 432
peroxidase 400
glutathione peroxidase 392
NADPH oxidase 352
aldehyde dehydrogenase 210
lactate dehydrogenase 202
aldehyde oxidase 171
glucose oxidase 138
NO synthase 124
glutathione reductase 123
lipoxygenase 121
adenosine deaminase 119
adenosine deaminase 118
ATPase 109
uricase 103
mitogen-activated protein kinase 93
protein kinase C 87
NQO1 70
aspartate aminotransferase 67
alanine aminotransferase 65
alkaline phosphatase 60
phospholipase A2 59
glutathione S-transferase 59
creatine kinase 58
glucose-6-phosphate dehydrogenase 54
diaphorase 53
purine nucleoside phosphorylase 53
caspase-3 53
tyrosinase 49
aldehyde dehydrogenase 49
ornithine decarboxylase 46
NOS 44
CPR 44
sulfite oxidase 44
sulfite oxidase 43
nitrate reductase 42
nitrate reductase 42
complex I 42
nitrate reductase 42
protein kinase 42
nitrate reductase 42
nitrate reductase 41
nitrate reductase 41
monoamine oxidase 40
trypsin 40
elastase 39
alcohol dehydrogenase 39
aldehyde dehydrogenase 38
aldehyde dehydrogenase 38
aldehyde dehydrogenase 38
5'-nucleotidase 34
hypoxanthine-guanine phosphoribosyltransferase 33
guanylate cyclase 33
guanase 33
succinate dehydrogenase 30
gamma-glutamyl transpeptidase 29
collagenase 28
ceruloplasmin 28
ERK 28
renin 27
acetylcholinesterase 26
heme oxygenase 24
NADPH-diaphorase 23
ACE 23
diaphorase 23
N-acetyltransferase 22
phosphodiesterase 22
lipase 21
NADH dehydrogenase 18
thrombin 18
ACS 17
cytochrome oxidase 17
PARP 16
phospholipase C 16
alpha-glucosidase 16
aconitase 16
chymotrypsin 15
paraoxonase 15
MEK 15
urease 14
urease 14
lysozyme 14
paraoxonase 14
DCF 13
caspase-1 13
luciferase 12
neutrophil elastase 12
focal adhesion kinase 12
15-lipoxygenase 12
AST 12
adenine phosphoribosyltransferase 11
thiopurine methyltransferase 11
thioredoxin reductase 11
beta-glucuronidase 11
nitrite reductase 11
proteasome 11
nitrite reductase 11
nitrite reductase 11
aldose reductase 10
AMP deaminase 10
carbonic anhydrase 10
acid phosphatase 10
phospholipase D 10
diamine oxidase 9
glutamate dehydrogenase 9
RNase 9
adenylate cyclase 9
RNase 9
ascorbate peroxidase 9
nitrogenase 9
glyceraldehyde-3-phosphate dehydrogenase 9
prostacyclin synthase 9
hyaluronidase 9
hexokinase 9
glucose-6-phosphatase 9
glyceraldehyde-3-phosphate dehydrogenase 9
IMP dehydrogenase 8
AMP-activated protein kinase 8
phosphatidylinositol 3-kinase 8
IKK 8
hyaluronidase 8
NADH-cytochrome b5 reductase 8
cholinesterase 8
isocitrate dehydrogenase 8
arginase 8
isocitrate dehydrogenase 8
glyceraldehyde-3-phosphate dehydrogenase 7
deaminase 7
glutamate dehydrogenase 7
glutamate dehydrogenase 7
ascorbate oxidase 7
indoleamine 2,3-dioxygenase 7
CYP3A4 7
adenosine kinase 7
thymidine kinase 7
MAP 7
glyceraldehyde-3-phosphate dehydrogenase 7
MPP 7
invertase 7
demethylase 7
prostaglandin synthetase 7
glyceraldehyde-3-phosphate dehydrogenase 7
plasmin 7
nucleotidase 7
peroxiredoxin 6
ADH 6
calcineurin 6
amidophosphoribosyltransferase 6
DNA ligase 6
DNA ligase 6
caspase-9 6
thromboxane synthase 6
allantoicase 6
beta-galactosidase 6
endonuclease 6
allantoinase 6
more...
Compound
oxygen 2908
hydrogen 965
H2O2 798
nitric oxide 624
Dec 606
iron 575
DNA 561
superoxide radical 465
sodium 400
water 389
calcium 372
Clin 367
HPP 345
GSH 334
GSH 334
molybdenum 313
glucose 301
NADPH 275
NADPH 275
phosphate 263
ATP 254
acetate 249
NADH 247
nitrogen 245
ethanol 240
arginine 198
aldehyde 196
potassium 190
NAD 188
copper 183
cysteine 172
EDTA 146
EDTA 144
creatinine 141
NAD 140
DPPH 132
acetaldehyde 124
ADP 124
urea 122
nicotinamide 120
Xanthine 112
Uric acid 108
ADP 108
ADP 108
sulfate 102
methanol 95
zinc 95
salt 94
CO2 92
aldehyde 91
Cardiol 90
tyrosine 89
cyanide 87
nitrate 87
DMSO 86
TNF 86
FAD 84
N-acetylcysteine 76
PEG 72
manganese 72
ethyl acetate 72
Phe 71
caffeine 71
tungsten 71
GSSG 69
MDA 66
pyrimidine 65
pyrimidine 65
AMP 64
glutamate 64
Hypoxanthine 60
methionine 56
galactose 56
ammonium 56
hydroxide 55
chromate 55
His 50
prostacyclin 50
selenium 49
iodine 47
PMA 46
SDS 45
PEG 45
phenazine 45
cGMP 44
bromide 44
PMA 42
NADP 42
phenol 41
diacetate 41
gallic acid 40
DFO 40
Oxypurinol 40
chloroform 38
tryptophan 37
NO3 37
thiourea 37
tryptophan 37
Malondialdehyde 37
tryptophan 36
alcohol dehydrogenase 36
lysine 36
tryptophan 36
HCl 35
leucine 35
hexane 34
Cu(II) 34
NBT 34
kaempferol 33
acetone 32
Tiron 31
cadmium 31
acetic acid 30
Vitamin E 30
pyrene 30
MTT 30
serine 30
alanine 29
Ascorbic acid 29
hydroxylamine 29
ammonia 28
Quercetin 28
benzene 28
CAT 27
CAT 27
Adenosine 27
myricetin 27
IMP 27
CAT 27
hydroquinone 26
ACh 26
cAMP 26
formaldehyde 26
GTP 26
Adriamycin 25
formaldehyde 25
alloxan 25
benzoic acid 24
PGE2 24
hydroxylamine 24
Melatonin 23
noradrenaline 23
NH2 23
8-OHdG 22
silicon 22
tert-butyl hydroperoxide 21
pyridine 21
hyaluronic acid 21
Gly 20
Indomethacin 20
ADP-ribose 20
Adenine 20
glycerol 20
Tris 20
acetonitrile 19
Mannitol 19
Tempol 19
Mannitol 19
Purine 19
5-HT 18
more...