Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P47989 (
xanthine oxidase
)
8,633
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
xanthine oxidase
8633
superoxide dismutase
1695
catalase
1335
Sep
624
xanthine dehydrogenase
403
glutathione peroxidase
385
Mol
334
GSH
308
SOD
279
nitric oxide synthase
277
NADPH
275
ATP
254
NADH
249
myeloperoxidase
235
cytochrome c
216
Superoxide dismutase
191
lactate dehydrogenase
188
aldehyde oxidase
180
cyclooxygenase
167
peroxidase
162
microsomal
153
Catalase
141
NAD
140
tumor necrosis factor
125
glutathione reductase
122
lipoxygenase
120
NMR
120
adenosine deaminase
118
lipopolysaccharide
118
albumin
113
xanthine oxidoreductase
111
ROS
110
ADP
108
inducible nitric oxide synthase
99
ATPase
98
insulin
96
EPR
92
cytochrome P450
91
TNF
86
cytokine
85
FAD
84
reductase
83
antioxidant enzyme
73
AMP
73
collagen
71
caspase-3
69
cytochrome P-450
67
ESR
65
serum albumin
65
cytochrome
63
hemoglobin
63
alkaline phosphatase
60
XDH
58
purine nucleoside phosphorylase
57
aspartate aminotransferase
56
oxidoreductase
56
NOT
55
NAD+
55
gut
54
angiotensin II
51
IL-6
51
MnSOD
51
endothelial nitric oxide synthase
50
glucose-6-phosphate dehydrogenase
49
thymus
48
p38
47
tyrosinase
47
vascular endothelium
46
TNF-alpha
46
spermatozoa
46
ornithine decarboxylase
46
heme oxygenase-1
45
phospholipase A2
45
ferritin
45
endoplasmic reticulum
44
sulfite oxidase
43
CO2
43
amylase
43
glutathione S-transferase
41
alanine aminotransferase
41
flavoprotein
41
SDS
38
aldehyde dehydrogenase
38
creatine kinase
37
manganese superoxide dismutase
36
hypoxanthine-guanine phosphoribosyltransferase
35
SIN
35
Bcl-2
34
eNOS
34
LPS
33
5'-nucleotidase
32
alcohol dehydrogenase
32
MAPK
32
bradykinin
32
polypeptide
32
glucosidase
32
interleukin-6
31
casein
31
Pseudomonas
31
CYP1A2
30
interferon-gamma
29
guanylate cyclase
28
ESI
28
endothelin-1
28
P450
27
COX-2
27
lactoperoxidase
27
renin
27
CAT
27
nucleoside phosphorylase
26
GTP
26
mast cell
26
LDH
25
matrix metalloproteinase
25
p47
25
membrane-bound
25
IMP
25
xenobiotic
25
metallothionein
25
NADPH-cytochrome P-450 reductase
24
DT-diaphorase
24
NADP
24
NMDA receptor
24
myoglobin
23
ERK1
23
PEG
23
transferrin
23
cyclooxygenase-2
23
interferon
22
N-acetyltransferase
22
acetylcholinesterase
22
butyrophilin
22
Gen
22
P-selectin
21
urate transporter 1
21
Ang II
21
Myeloperoxidase
21
5-lipoxygenase
20
lipase
20
ceruloplasmin
20
gamma-glutamyl transpeptidase
20
IL-1
20
C-reactive protein
20
p53
20
PKC
20
glycoprotein
20
NLRP3
20
phosphodiesterase
19
IL-10
19
mitogen-activated protein
19
ICAM-1
19
SOD1
19
ERK
19
lactoferrin
19
p65
19
NADH dehydrogenase
18
glucose transporter
18
CPR
18
thrombin
18
collagenase
18
more...
Disease
ischemia
695
gout
380
hyperuricemia
365
GSH
308
cancer
274
diabetes
191
hypertension
189
tumor
177
atherosclerosis
137
heart failure
98
arthritis
89
cardiovascular disease
81
depression
79
myocardial ischemia
76
carcinogenesis
74
myocardial infarction
59
renal disease
57
NAME
56
stroke
53
obesity
52
cerebral ischemia
50
sepsis
46
cold
45
sepsis
44
hyperglycemia
43
metabolic syndrome
42
hypercholesterolemia
40
Alzheimer's disease
39
acute pancreatitis
38
SDS
38
carcinoma
37
type 2 diabetes
33
pulmonary edema
32
renal ischemia
32
SEM
32
pancreatitis
31
hepatocellular carcinoma
28
tophi
26
renal failure
26
pulmonary hypertension
24
vascular disease
24
leukemia
24
plaque
22
acute myocardial infarction
22
preeclampsia
22
rheumatoid arthritis
21
hepatitis
21
adult respiratory distress syndrome
20
urolithiasis
20
hyperlipidemia
20
asthma
19
mole
19
acute renal failure
19
proteinuria
19
melanoma
19
breast cancer
19
immunodeficiency
19
mole
19
renal impairment
19
influenza
18
Parkinson's disease
18
coronary artery disease
18
congestive heart failure
18
malaria
17
chronic granulomatous disease
16
renal insufficiency
15
tumorigenesis
15
inflammatory bowel disease
14
virus infection
14
tumor lysis syndrome
14
MCF
14
HIV
14
prostate cancer
14
rheumatism
14
ulcerative colitis
13
diabetic nephropathy
13
colitis
13
metabolic disorder
13
ventricular fibrillation
13
tuberculosis
13
Endothelial dysfunction
12
fatty liver
12
Mycobacterium
12
tumor growth
12
glomerulosclerosis
12
dementia
12
coronary heart disease
12
Evans
12
cirrhosis
12
worms
12
Lesch-Nyhan syndrome
11
chronic obstructive pulmonary disease
11
sickle cell disease
11
cardiomyopathy
11
multiple sclerosis
11
celiac disease
11
West
11
liver disease
11
acute promyelocytic leukemia
10
colorectal cancer
10
infectious diseases
10
heart disease
10
epilepsy
10
iron overload
10
cystic fibrosis
10
coronary occlusion
9
cornea
9
nephrolithiasis
9
fits
9
lymphoma
9
Placenta
9
gastric ulcer
9
ATM
9
neuroblastoma
9
nephrosis
9
brain edema
9
ADA deficiency
9
ventricular hypertrophy
9
cataract
9
dehydration
9
osteoarthritis
8
Infection
8
dyslipidemia
8
Chagas
8
acute lymphoblastic leukemia
8
solid tumor
8
anemia
8
necrotizing enterocolitis
8
essential hypertension
8
bacterial infection
8
diabetic retinopathy
8
Blocking
8
amyotrophic lateral sclerosis
8
neutropenia
8
glucose intolerance
8
premenstrual syndrome
8
Pineal
8
pheochromocytoma
8
cholestasis
8
adenocarcinoma
8
SAR
8
PMS
8
alcoholic fatty liver
7
leukopenia
7
infertility
7
Schistosoma mansoni
7
Crohn's disease
7
liver fibrosis
7
bladder cancer
7
APRT deficiency
7
skin tumor
7
dermatitis
7
chronic renal failure
7
colon cancer
7
rash
7
PAPA
7
mastitis
7
pertussis
7
Gouty arthritis
7
hepatitis B
7
more...
Symptom
hyperoxia
30
anesthesia
26
pain
24
seizures
18
fatigue
16
functional recovery
13
angina
12
diarrhea
12
exhaustion
12
respiratory distress
11
hypothermia
10
starvation
10
skin damage
7
acidity
6
collapse
5
nausea
5
vomiting
5
weakness
5
erythema
5
headache
5
hypercapnia
3
overweight
3
oliguria
3
arthralgia
3
Anoxia
3
dizziness
3
myalgia
3
cachexia
3
Ill
2
hypocapnia
2
flushing
2
discomfort
2
anorexia
2
discomfort
2
twitching
2
chest pain
2
abdominal pain
2
colic
2
agitation
2
autodigestion
2
dry eye
2
acute stress
2
thinning
2
memory loss
1
skin irritation
1
pelvic pain
1
polyuria
1
tonic-clonic seizure
1
asthenia
1
hypertonia
1
hypotonia
1
renal colic
1
prostration
1
muscle rigidity
1
hepatosplenomegaly
1
exertional dyspnea
1
leg edema
1
athetosis
1
HSA
1
neuralgia
1
paresis
1
eds
1
No adverse effect
1
spasm
1
rigors
1
catarrh
1
ketonuria
1
disturbed balance
1
sleepiness
1
throat irritation
1
Macula
1
hyperesthesia
1
dystonia
1
Drug
NADH
247
ascorbate
213
vitamin E
135
ROS
110
FAD
84
Cardiovasc
84
Febuxostat
76
caffeine
71
Indomethacin
33
Dermatol
32
NBT
32
Ethanol
27
lysine
26
Glutathione
24
Vitamin E
19
nitroglycerin
17
IFN-gamma
15
Adriamycin
15
Desferal
14
Desferal
14
FeCl3
14
Rasburicase
13
Albumin
12
Mutagen
11
CaCl2
10
CaCl2
10
CaCl2
10
Nitric Oxide
10
Gel
10
Ringer's solution
9
Methylene blue
9
CSF
9
L-tyrosine
9
Adenosine deaminase
9
Angiotensin II
8
IL-2
8
Leaf
8
Monit
8
Nephron
8
MAP
7
Vitamin K
7
balanced salt solution
7
Acacia
7
Y-700
7
Photofrin
6
Myricetin
6
Sodium nitroprusside
6
Spectrum
6
Captopril
6
Propofol
6
Nephron
6
Fructose
6
Rasburicase
5
Cimetidine
5
NH3
5
Rebamipide
5
BH4
5
Fluorescein
5
pyridoxal phosphate
5
Arsenic trioxide
5
Rutin
5
Cimetidine
5
Glycyrrhiza
5
Ouabain
4
Heme
4
CTX
4
Histamine
4
ZnO
4
Omeprazole
4
Aloe
4
CAM
4
ETA
4
DNase I
4
TMX
4
TiO2
3
MgSO4
3
Ginseng
3
Zinc sulfate
3
Riboflavin
3
Carotenoid
3
SiO2
3
Fraction
3
Iloprost
3
ICI
3
Sesame oil
3
Moco
3
THF
3
niacin
3
APD
3
Portal
3
Dial
3
Zinc sulfate
3
Malonaldehyde
3
EPA
2
NAG
2
ABC
2
ENT
2
Lodoxamide tromethamine
2
Capsicum
2
Atractylodes rhizome
2
Acyclovir
2
ddI
2
Retinoic acid
2
FCV
2
Asn
2
CoCl2
2
CoCl2
2
Triclosan
2
Tirapazamine
2
Rosuvastatin
2
Ginger
2
Sesamol
2
RAL
2
Adenosine triphosphate
2
Phosphatidylserine
2
PTH
2
Silica gel
2
Pirfenidone
2
Scutellaria root
2
Silica
2
Lovastatin
2
ALA
2
Meth
2
Sucralfate
2
citric acid
2
Tantum
2
all-trans-retinol
2
Ketotifen
2
Cellulose acetate
2
Gastro
2
Troglitazone
2
Vitamin B
1
Diphenhydramine
1
Asthma
1
Amflutizole
1
7,8-Dihydroneopterin
1
NaI
1
Nilvadipine
1
Zovirax
1
Lisofylline
1
Trifluoperazine
1
Nebivolol
1
Piracetam
1
SNL
1
Vena
1
C3H6
1
Indapamide
1
Valsartan
1
DMSA
1
Vitamin K2
1
Dezaguanine
1
Biopolymers
1
Doxycycline
1
EE2
1
Pyridoxal
1
Caraway
1
Gelatin
1
Compound 19
1
Troxipide
1
Lead acetate
1
more...
Enzyme
xanthine oxidase
7867
superoxide dismutase
1868
catalase
1347
xanthine dehydrogenase
459
NADPH oxidase
432
peroxidase
400
glutathione peroxidase
392
NADPH oxidase
352
aldehyde dehydrogenase
210
lactate dehydrogenase
202
aldehyde oxidase
171
glucose oxidase
138
NO synthase
124
glutathione reductase
123
lipoxygenase
121
adenosine deaminase
119
adenosine deaminase
118
ATPase
109
uricase
103
mitogen-activated protein kinase
93
protein kinase C
87
NQO1
70
aspartate aminotransferase
67
alanine aminotransferase
65
alkaline phosphatase
60
phospholipase A2
59
glutathione S-transferase
59
creatine kinase
58
glucose-6-phosphate dehydrogenase
54
diaphorase
53
purine nucleoside phosphorylase
53
caspase-3
53
tyrosinase
49
aldehyde dehydrogenase
49
ornithine decarboxylase
46
NOS
44
CPR
44
sulfite oxidase
44
sulfite oxidase
43
nitrate reductase
42
nitrate reductase
42
complex I
42
nitrate reductase
42
protein kinase
42
nitrate reductase
42
nitrate reductase
41
nitrate reductase
41
monoamine oxidase
40
trypsin
40
elastase
39
alcohol dehydrogenase
39
aldehyde dehydrogenase
38
aldehyde dehydrogenase
38
aldehyde dehydrogenase
38
5'-nucleotidase
34
hypoxanthine-guanine phosphoribosyltransferase
33
guanylate cyclase
33
guanase
33
succinate dehydrogenase
30
gamma-glutamyl transpeptidase
29
collagenase
28
ceruloplasmin
28
ERK
28
renin
27
acetylcholinesterase
26
heme oxygenase
24
NADPH-diaphorase
23
ACE
23
diaphorase
23
N-acetyltransferase
22
phosphodiesterase
22
lipase
21
NADH dehydrogenase
18
thrombin
18
ACS
17
cytochrome oxidase
17
PARP
16
phospholipase C
16
alpha-glucosidase
16
aconitase
16
chymotrypsin
15
paraoxonase
15
MEK
15
urease
14
urease
14
lysozyme
14
paraoxonase
14
DCF
13
caspase-1
13
luciferase
12
neutrophil elastase
12
focal adhesion kinase
12
15-lipoxygenase
12
AST
12
adenine phosphoribosyltransferase
11
thiopurine methyltransferase
11
thioredoxin reductase
11
beta-glucuronidase
11
nitrite reductase
11
proteasome
11
nitrite reductase
11
nitrite reductase
11
aldose reductase
10
AMP deaminase
10
carbonic anhydrase
10
acid phosphatase
10
phospholipase D
10
diamine oxidase
9
glutamate dehydrogenase
9
RNase
9
adenylate cyclase
9
RNase
9
ascorbate peroxidase
9
nitrogenase
9
glyceraldehyde-3-phosphate dehydrogenase
9
prostacyclin synthase
9
hyaluronidase
9
hexokinase
9
glucose-6-phosphatase
9
glyceraldehyde-3-phosphate dehydrogenase
9
IMP dehydrogenase
8
AMP-activated protein kinase
8
phosphatidylinositol 3-kinase
8
IKK
8
hyaluronidase
8
NADH-cytochrome b5 reductase
8
cholinesterase
8
isocitrate dehydrogenase
8
arginase
8
isocitrate dehydrogenase
8
glyceraldehyde-3-phosphate dehydrogenase
7
deaminase
7
glutamate dehydrogenase
7
glutamate dehydrogenase
7
ascorbate oxidase
7
indoleamine 2,3-dioxygenase
7
CYP3A4
7
adenosine kinase
7
thymidine kinase
7
MAP
7
glyceraldehyde-3-phosphate dehydrogenase
7
MPP
7
invertase
7
demethylase
7
prostaglandin synthetase
7
glyceraldehyde-3-phosphate dehydrogenase
7
plasmin
7
nucleotidase
7
peroxiredoxin
6
ADH
6
calcineurin
6
amidophosphoribosyltransferase
6
DNA ligase
6
DNA ligase
6
caspase-9
6
thromboxane synthase
6
allantoicase
6
beta-galactosidase
6
endonuclease
6
allantoinase
6
more...
Compound
oxygen
2908
hydrogen
965
H2O2
798
nitric oxide
624
Dec
606
iron
575
DNA
561
superoxide radical
465
sodium
400
water
389
calcium
372
Clin
367
HPP
345
GSH
334
GSH
334
molybdenum
313
glucose
301
NADPH
275
NADPH
275
phosphate
263
ATP
254
acetate
249
NADH
247
nitrogen
245
ethanol
240
arginine
198
aldehyde
196
potassium
190
NAD
188
copper
183
cysteine
172
EDTA
146
EDTA
144
creatinine
141
NAD
140
DPPH
132
acetaldehyde
124
ADP
124
urea
122
nicotinamide
120
Xanthine
112
Uric acid
108
ADP
108
ADP
108
sulfate
102
methanol
95
zinc
95
salt
94
CO2
92
aldehyde
91
Cardiol
90
tyrosine
89
cyanide
87
nitrate
87
DMSO
86
TNF
86
FAD
84
N-acetylcysteine
76
PEG
72
manganese
72
ethyl acetate
72
Phe
71
caffeine
71
tungsten
71
GSSG
69
MDA
66
pyrimidine
65
pyrimidine
65
AMP
64
glutamate
64
Hypoxanthine
60
methionine
56
galactose
56
ammonium
56
hydroxide
55
chromate
55
His
50
prostacyclin
50
selenium
49
iodine
47
PMA
46
SDS
45
PEG
45
phenazine
45
cGMP
44
bromide
44
PMA
42
NADP
42
phenol
41
diacetate
41
gallic acid
40
DFO
40
Oxypurinol
40
chloroform
38
tryptophan
37
NO3
37
thiourea
37
tryptophan
37
Malondialdehyde
37
tryptophan
36
alcohol dehydrogenase
36
lysine
36
tryptophan
36
HCl
35
leucine
35
hexane
34
Cu(II)
34
NBT
34
kaempferol
33
acetone
32
Tiron
31
cadmium
31
acetic acid
30
Vitamin E
30
pyrene
30
MTT
30
serine
30
alanine
29
Ascorbic acid
29
hydroxylamine
29
ammonia
28
Quercetin
28
benzene
28
CAT
27
CAT
27
Adenosine
27
myricetin
27
IMP
27
CAT
27
hydroquinone
26
ACh
26
cAMP
26
formaldehyde
26
GTP
26
Adriamycin
25
formaldehyde
25
alloxan
25
benzoic acid
24
PGE2
24
hydroxylamine
24
Melatonin
23
noradrenaline
23
NH2
23
8-OHdG
22
silicon
22
tert-butyl hydroperoxide
21
pyridine
21
hyaluronic acid
21
Gly
20
Indomethacin
20
ADP-ribose
20
Adenine
20
glycerol
20
Tris
20
acetonitrile
19
Mannitol
19
Tempol
19
Mannitol
19
Purine
19
5-HT
18
more...