Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P47989 (xanthine oxidase)
 8,633 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Superoxide scavenging activity (SSA) of recently synthesized isonicotinoylhydrazones, analogs of the clinically used anti-tuberculosis drug isoniazid (INH), was investigated using xanthine/xanthine oxidase system to generate the superoxide anion. The isonicotinoylhydrazones exhibited well expressed SSA, whereas INH did not show any SSA. All of the isonicotinoylhydrazones had a tuberculostatic activity when tested with the standard strain of Mycobacterium tuberculosis H(37)R(v) and some of them had a higher tuberculostatic activity than INH. A lower acute toxicity was also observed compared to INH. Moreover, a correlation was observed between LD(50) and SSA for the isonicotinoylhydrazones studied. An explanation is suggested for the higher tuberculostatic activity and lower acute toxicity of some of the isonicotinoylhydrazones as compared to that of INH. A new route to less toxic derivatives of INH with potential tuberculostatic activity is proposed.
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PMID:Isonicotinoylhydrazone analogs of isoniazid: relationship between superoxide scavenging and tuberculostatic activities. 1205 80

New perylenebisimide derivatives hydroxyperylenebisimide and naphthoperylenebisimide were obtained and applied to construct a new solvatochromic dyad 9. The solvatochromic behavior of hydroxyperylenebisimide was studied, and the structure of naphthoperylenebisimide was determined by X-ray crystallography. The spectral studies indicated that the hydroxyperylenebisimide and naphthoperylenebisimide units of dyad 9 were strongly coupled in the ground state, and as a result the fluorescence of the naphthoperylenebisimide unit was almost quenched and that of the hydroxyperylenebisimide unit was greatly enhanced due to the fluorescence resonance energy transfer (FRET). As we expected, this FRET process could be tuned with the addition of protons, base, and ferric ions. This behavior of dyad 9 could be interpreted by a two-input INH logic gate, while in the presence of Fe(III), the ion complex of 9 could execute a two-input XOR logic gate. By changing the output signal, a combinational logic circuit with three inputs could also be interpreted.
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PMID:Photonic logic gates based on control of FRET by a solvatochromic perylene bisimide. 1736 40

Photochromes are photoswitchable, bistable chromophores which, like transistors, can implement binary logic operations. When several photochromes are combined in one molecule, interactions between them such as energy and electron transfer allow design of simple Boolean logic gates and more complex logic devices with all-photonic inputs and outputs. Selective isomerization of individual photochromes can be achieved using light of different wavelengths, and logic outputs can employ absorption and emission properties at different wavelengths, thus allowing a single molecular species to perform several different functions, even simultaneously. Here, we report a molecule consisting of three linked photochromes that can be configured as AND, XOR, INH, half-adder, half-subtractor, multiplexer, demultiplexer, encoder, decoder, keypad lock, and logically reversible transfer gate logic devices, all with a common initial state. The system demonstrates the advantages of light-responsive molecules as multifunctional, reconfigurable nanoscale logic devices that represent an approach to true molecular information processing units.
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PMID:All-photonic multifunctional molecular logic device. 2156 23

This work demonstrates two DNA-based logic circuits that behave as a half-adder and a half-subtractor. A half-adder is composed of an AND gate and an XOR gate, whereas a half-subtractor consists of an INH gate and an XOR gate. The proposed designs are inspired by molecular beacons.
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PMID:Molecular beacon-based half-adder and half-subtractor. 2205 75

Right out of the (logic) gate: Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half-adder circuit. These DNA logic gates were also applied to intracellular detection of ATP.
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PMID:Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors. 2288 92

This study introduces an optical DNA-based logic circuit that mimics a half-subtractor. The system contains an Au-surface immobilized molecular-beacon molecule that serves as a dual-gate molecule and outputs two series of fluorescence signals following Boolean INH and XOR patterns after interacting with one or two single-stranded DNA molecules as input. To the best of our knowledge, the system reported herein is rather concise compared to other molecular logic gate systems.
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PMID:An optical deoxyribonucleic acid-based half-subtractor. 2396 12

A simple, toehold-mediated two-way input DNA machine has been developed. Utilizing symmetric and asymmetric protector sequences, INH, XOR logic gates and a half-subtractor are designed based on this two-way structure.
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PMID:Toehold-mediated DNA logic gates based on host-guest DNA-GNPs. 2486 23

Despite the widespread use of quantum dots (QDs) for biosensing and bioimaging, QD-based bio-interfaceable and reconfigurable molecular computing systems have not yet been realized. DNA-programmed dynamic assembly of multi-color QDs is presented for the construction of a new class of fluorescence resonance energy transfer (FRET)-based QD computing systems. A complete set of seven elementary logic gates (OR, AND, NOR, NAND, INH, XOR, XNOR) are realized using a series of binary and ternary QD complexes operated by strand displacement reactions. The integration of different logic gates into a half-adder circuit for molecular computation is also demonstrated. This strategy is quite versatile and straightforward for logical operations and would pave the way for QD-biocomputing-based intelligent molecular diagnostics.
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PMID:DNA-programmed dynamic assembly of quantum dots for molecular computation. 2535 67

Despite some visual colorimetric chemical logic gates having been reported, a complete set of six basic logic gates have not been realized to date. Moreover, the application of the reported logic gates needs to be further extended. Herein, the label-free molybdenum oxide nanomaterials are presented for the construction of a new visual colorimetric molecular computing system. A complete set of six basic colorimetric logic gates (OR, AND, NOR, NAND, XOR, XNOR) and the INH logic gate are realized based on plasmonic switching in MoO3 nanomaterials. In addition, the rational integration of different logic gates into a 1:2 demultiplexer circuit is also testified.
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PMID:Versatile Visual Logic Operations Based on Plasmonic Switching in Label-Free Molybdenum Oxide Nanomaterials. 2929 Jan 5

Logic systems that yield two or more signal outputs in the presence of the input are scarce. A universal logic system consisting of plasmonic MoO3-x nanodots and 3,3'-diaminobenzidine (DAB) for fabrication of visual contrary logic pairs and circuits are presented here. They do not require the use of expensive instrumentation but can be visually read. It is based on the facts that the blue dispersion of MoO3-x nanodots turns to colorless after oxidation, while the colorless reagent DAB is oxidized by various oxidants to generate a brown color. On this basis, the complete contrary logic pairs and circuits such as YES-NOT, AND-NAND, OR-NOR, XOR-XNOR, INH-IMH, and MAJ-MIN can be fabricated. Various oxidants serve as inputs, and absorbances as outputs. A smart logic voting system with "one-vote deny" function is also described that is based on the cascade of MAJ logic circuit and INH logic gate using ascorbic acid (AA) as the superior denier. All the logic operations can visually read due to the appearance of distinct color changes. Graphical abstract Schematic presentation of the contrary logic pairs and circuits using a visually and colorimetrically detectable redox system consisting of MoO3-x nanodots and 3,3'-diaminobenzidine.
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PMID:Contrary logic pairs and circuits using a visually and colorimetrically detectable redox system consisting of MoO3-x nanodots and 3,3'-diaminobenzidine. 3062 52


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