Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P47989 (
xanthine oxidase
)
8,633
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The anti-rheumatic drug tenidap has been shown previously to attenuate superoxide production by activated neutrophils. Given the importance of leukocyte as well as endothelial cell derived superoxide in mediating inflammatory responses, the effects of tenidap on mammalian enzymes capable of generating superoxide were determined.
Tenidap
had no effect on the generation of superoxide by NADPH oxidase reconstituted from fractionated neutrophil lysates. However, significant inhibition of superoxide production by mixtures of hypoxanthine and
xanthine oxidase
was observed in the presence of 3-30 micrograms/mL tenidap. The kientics of
xanthine oxidase
inhibition by tenidap were non-competitive; the Ki of tenidap for
xanthine oxidase
was 11 micrograms/mL (34 microM). No inhibition of
xanthine oxidase
was observed in the presence of other known inhibitors of cyclooxygenase. Inhibition of
xanthine oxidase
may be a heretofore unrecognized mechanism of the antirheumatic effects of tenidap.
...
PMID:Effects of tenidap on superoxide-generating enzymes. Non-competitive inhibition of xanthine oxidase. 757 42
