Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P47989 (xanthine oxidase)
 8,633 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of regulatory peptides (somatostatin, calcitonin, and dalargin) on xanthine oxidase activity and lipid peroxidation level in pancreatic tissues as well as on the release of pancreatic enzymes (alpha-amylase, trypsin, lipase, and transamidinase) into blood was studied in 205 rats with experimental acute pancreatitis. Somatostatin and dalargin were shown to have obvious antioxidant effect seen by reduced xanthine oxidase activity and MDA level. All studied peptides stimulate reduced release of pancreatic enzymes. Particularly, reduction of dalargin and somatostatin is caused by inhibition of their synthesis as well as by pancreas protective effect of the peptides. Release of enzymes reduced by calcitonin is probably associated only with inhibition of secretory activity of the pancreas.
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PMID:[Effects of several regulatory peptides on the functional activity of the pancreas in acute experimental pancreatitis]. 259 53

Experiments were conducted on 268 male albino rats with modeled acute pancreatitis to study the xanthine oxidase (XO) activity in the pancreatic tissue during intraperitoneal administration of stimulators of pancreatic exocrine function (pilocarpine) and inhibitors of enzyme activity (allopurinol). Pilocarpine (0.1 mg/kg) increased XO activity by 90-100% one-three hours after injection, which was due to increased synthesis of the enzyme. Allopurinol (500 mg/kg) inhibiting XO activity removes the XO activating effect of pilocarpine in the first two hours after injection. It was established that one of the tranquilizers of the 1,4-benzodiazepine series--seduxen (15 mg/kg) produces an inhibiting effect on XO activity and, like allopurinol, removes the XO activating effect of pilocarpine. Complete parallelism was also revealed between the dynamics of changes of XO activity in the pancreatic tissue and alpha-amylase in blood under the effect of the preparations studied.
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PMID:[Role of xanthine oxidase in the genesis of acute pancreatitis]. 275 30