Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P47989 (
xanthine oxidase
)
8,633
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
As many as 76 patients suffering from inactive
rheumatic fever
associated with different stages of heart failure were examined for uricemia, diurnal uricosuria, and
xanthine oxidase
activity in blood serum. It was established that in
rheumatic fever
, the activity of
xanthine oxidase
increased even at the early stages of heart failure. The presence in some of the patient of the enzyme activation combined with hyperuricosuria and normal content of uric acid in blood serum suggests "latent" hyperuricemia. In patients with severe heart decompensation, there was an appreciable activation of
xanthine oxidase
, which correlated, as a rule, with high hyperuricemia. Activation of
xanthine oxidase
in patients with
rheumatic fever
evidences hyperproduction of uric acid. It is advisable that in such cases the uricodepressive treatment may be indicated.
...
PMID:[Changes in xanthine oxidase activity in patients with circulatory failure]. 278 95
