Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P46098 (
5-HT3 receptor
)
2,290
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have isolated the murine gene encoding the
5-HT3 receptor
(
5-HT3R
), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the
5-HT3R
gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use of exon 9 splice acceptor sites generated two
5-HT3R
variants. The
5-HT3R
gene, whose structure is closely related to neuronal and muscle
AChR
alpha genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.
...
PMID:Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11. 811 71
