Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UNIPROT:P43146 (tumour suppressor)
5,935 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein tumour suppressor 5935 p53 2001 Mol 462 Sep 378 PTEN 233 p16 206 p21 184 BRCA1 141 phosphatase 141 histone 127 ubiquitin 120 MDM2 118 INK4a 115 E-cadherin 113 mutant p53 101 p16INK4a 99 catenin 93 APC 91 BRCA2 87 adenomatous polyposis coli 87 CDKN2A 85 ARF 85 AKT 84 ras 82 cyclin 81 PI3K 80 beta-catenin 79 p73 79 proteasome 78 mTOR 76 Bcl-2 72 cyclin D1 72 pRb 71 proto-oncogene 70 LKB1 68 ATM 68 E3 ubiquitin ligase 67 tensin 65 Mdm2 65 telomeric 62 cytokine 59 lymphoid 58 DCC 55 RB1 52 insulin 50 p27 49 c-myc 49 histone deacetylase 49 cage 48 p14 47 ubiquitin ligase 47 MAPK 46 pVHL 44 cyclin-dependent kinase 44 p63 43 ATP 43 caspase-3 43 p53 target 42 oestrogen receptor 41 merlin 41 EGFR 41 FHIT 40 RASSF1A 40 netrin-1 40 CDK4 39 proliferating cell nuclear antigen 39 threonine 39 neurofibromatosis 38 osteosarcoma 38 WAF1 36 KRAS 36 UTR 36 ERK 36 HER2 36 c-Myc 35 K-ras 35 NF2 35 WT1 35 phosphoinositide 3-kinase 34 AMP-activated protein kinase 34 more...

Disease cancer 2634 tumorigenesis 493 carcinogenesis 478 breast cancer 476 carcinoma 344 tumor 308 colorectal cancer 288 retinoblastoma 247 melanoma 201 leukemia 200 lung cancer 178 Hippel 175 metastases 145 prostate cancer 137 squamous cell carcinoma 133 hepatocellular carcinoma 131 ovarian cancer 115 adenocarcinoma 113 renal cell carcinoma 108 gastric cancer 94 APC 93 tumor progression 92 colon cancer 90 ARF 85 ATM 83 lymphoma 79 adenoma 79 glioma 70 WT1 69 neuroblastoma 68 familial adenomatous polyposis 66 dysplasia 64 acute myeloid leukemia 64 NF2 62 glioblastoma 62 multiple endocrine neoplasia 60 pancreatic cancer 60 cervical cancer 57 non-small cell lung cancer 54 MCF 47 bladder cancer 46 skin cancer 44 osteosarcoma 42 neurofibromatosis 41 renal cancer 41 endometrial cancer 38 liver cancer 37 tuberous sclerosis 37 Epstein 37 polyposis 37 lung carcinoma 37 neoplastic transformation 36 myelodysplastic syndrome 35 Melanoma 34 neurofibromatosis type 1 34 mesothelioma 33 epithelial ovarian cancer 32 aggressiveness 32 familial cancer 31 Li-Fraumeni syndrome 31 diabetes 31 thyroid cancer 31 virus infection 30 basal cell carcinoma 30 chronic lymphocytic leukemia 28 oral cancer 28 MEN1 27 multiple myeloma 27 glioblastoma multiforme 25 liver cancer 24 anemia 24 hepatitis B 23 Hodgkin's disease 23 Peutz-Jeghers syndrome 23 meningioma 23 malignant mesothelioma 23 Leukemia 23 suicide 22 mole 22 nevoid basal cell carcinoma syndrome 22 more...

Symptom starvation 13 seizures 10 collapse 7 pain 5 ataxia 5 cachexia 3 exhaustion 3 cerebellar ataxia 3 anesthesia 2 abdominal pain 2 diarrhea 2 dyspnea 2 splenomegaly 2 dystonia 2 nipple discharge 1 paraparesis 1 male subfertility 1 lethargy 1 headache 1 dizziness 1 erythema 1 pelvic pain 1 sore throat 1 masculinization 1 vomiting 1 chest pain 1 DNA marker 1 fatigue 1 nipple discharge 1 hemiplegia 1 tinnitus 1 thinning 1 skin damage 1 arthralgia 1 fever of unknown origin 1 acute stress 1 colic 1 CSR 1 numbness 1 livedo 1 insomnia 1 shoulder pain 1 flushing 1 prickling sensation 1

Drug lysine 56 Dermatol 36 ETS 11 Paraffin 9 ROS 9 MAP 7 MDM 6 NADH 6 Asn 5 Imatinib 5 CSF 5 TES 5 IL-2 4 GEO 4 IFN-gamma 4 ascorbate 4 Gleevec 4 DNase I 4 Mutagen 4 -deoxyadenosine 4 ABC 4 CAM 4 Parkin 3 caffeine 3 ENT 3 Parkin 3 AGG 3 ADM 3 MRC 3 G418 3 Retinoic acid 3 MDS 3 vitamin E 2 Spectrum 2 Alanine 2 Triad 2 ROC 2 Podophyllum 2 p75 2 Herceptin 2 Triad 2 DHT 2 Taxol 2 niacin 2 Azacytidine 2 DHT 2 PTH 2 Activin 2 ICI 2 CTX 2 PFT 2 ACT 2 TEL 2 IL-11 2 ROX 1 Propofol 1 OTC 1 MOF 1 Gel 1 CDX 1 Cardiovasc 1 KCL 1 Ginger 1 ZnO 1 TTC 1 PNT 1 Dacogen 1 Orphan 1 Ethanol 1 Everolimus 1 Vinorelbine 1 THF 1 PCB 1 Gelatin 1 Riboflavin 1 Clofarabine 1 CTT 1 R1881 1 RFP 1 Ranitidine 1 more...

Enzyme ERK 179 protein kinase 162 mitogen-activated protein kinase 118 APC 94 proteasome 78 luciferase 72 focal adhesion kinase 63 AMP-activated protein kinase 50 cdc2 47 phosphoinositide 3-kinase 34 DNA methyltransferase 33 calcineurin 32 RNA polymerase 30 caspase-3 29 PARP 29 protein kinase C 29 reverse transcriptase 24 AMPK 24 MEK 24 STK11 23 AMPK 23 phosphatidylinositol 3-kinase 19 ATPase 18 glutathione S-transferase 18 succinate dehydrogenase 13 histone acetyltransferase 11 fumarase 11 superoxide dismutase 10 caspase-8 10 protein phosphatase 2A 10 catalase 10 GSK 10 DNA polymerase 9 topoisomerase 9 NQO1 8 topoisomerase 8 IKK 7 endonuclease 7 glutathione peroxidase 7 MAP 7 PDK1 6 beta-galactosidase 6 prolyl hydroxylase 6 caspase-2 6 thymidine kinase 6 caspase-9 6 caspase-2 6 cathepsin D 5 PHD 5 DNA ligase 5 DNA ligase 5 peroxidase 5 MDR 5 hypoxanthine-guanine phosphoribosyltransferase 4 methylthioadenosine phosphorylase 4 ribonucleotide reductase 4 isocitrate dehydrogenase 4 ribonucleotide reductase 4 TOR 4 histone demethylase 4 polo-like kinase 1 4 demethylase 4 triphosphatase 4 thymidylate synthase 4 dihydrofolate reductase 4 TSA 4 urokinase-type plasminogen activator 4 PTPase 4 ADE2 3 NO synthase 3 caspase-1 3 trypsin 3 AGT 3 isocitrate dehydrogenase 3 alanine aminotransferase 3 glyceraldehyde-3-phosphate dehydrogenase 3 aspartate aminotransferase 3 lactate dehydrogenase 3 glutaminase 3 p100 3 more...

Compound DNA 1512 Dec 435 Clin 161 oxygen 132 urea 91 serine 85 tyrosine 74 lysine 65 threonine 63 arginine 63 DCC 55 ATP 43 glucose 39 MDA 38 calcium 37 zinc 34 phosphate 33 cysteine 32 alanine 30 His 28 AMP 28 proline 24 leucine 24 TNM 22 MTT 22 methionine 21 water 20 NAD 20 iron 18 5-Aza-2'-deoxycytidine 17 hydrogen 17 NAD 16 MEK 16 pyrene 16 retinoic acid 15 Histone 14 aflatoxin B1 14 nitric oxide 14 cAMP 14 GTP 13 TNF 13 Bisulfite 13 ADP 12 adenosylmethionine 12 Pac 12 ADP 12 ADP 12 glutamine 12 Insulin 12 boron 12 sodium 12 acetate 12 pyrimidine 11 pyrimidine 11 tryptophan 11 GAP 11 Asp 11 2-oxoglutarate 11 tryptophan 10 tryptophan 10 tryptophan 10 THE 9 SCC 9 NADPH 8 Phe 8 Serine 8 nitrogen 8 NADPH 8 iodine 8 Ubiquitin 8 glutamate 8 salt 7 BCR 7 COS 7 FAP 7 5-FU 7 MAP 7 FAP 7 vitamin D 7 DDP 7 more...

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