Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PHLDB3 12.4
PCDHGC3 12.4
APITD1 12.4
protein phosphatase 2A regulatory subunit A beta isoform 12.4
leucine-rich repeat-containing 2 12.4
GTF3C4 12.4
leucine zipper protein 3 12.4
Fus-2 12.4
RING finger protein 38 12.4
AMPH1 12.4
C9orf11 12.4
tumour suppressor 12.4
serine/threonine kinase 38 like 12.4
G protein gamma-4 subunit 12.4
ECTACC 12.4
KIP 2 12.4
TPTE and PTEN homologous inositol lipid phosphatase 12.4
BR serine/threonine kinase 1 11.4
TMEM196 11.4
CORO6 11.4
TRPM1 protein 11.4
endosulfine alpha 11.4
suppression of tumorigenicity 7-like 11.4
C9orf103 11.4
deleted in bladder cancer 1 11.4
FOXD4L6 11.4
SH3GL2 protein 11.4
FOXD4L1 11.4
LRRC2 11.4
NADH-ubiquinone oxidoreductase chain 4 11.4
truncated FHIT 11.4
progestin and adipoQ receptor family member III 11.4
ZNF454 11.4
LOH2CR12 11.4
NITRILASE 1 11.4
Hugl-1 11.2
apoptosis repressor with CARD domain 10.8
ZNF479 10.8
SnuCyp-20 10.8
LTM1 10.8
SNX32 10.8
ankyrin repeat domain 28 10.8
Kelch-like protein 6 10.8
MRLC3 10.8
Deleted in lung and esophageal cancer 1 10.8
LOH12CR1 10.8
nin one binding protein 10.8
PTPRK protein 10.8
ZNF169 10.8
GATA zinc finger domain containing 2A 10.8
hCAF-1 10.8
C9orf9 10.8
DBCCR1 10.6
LIG-1 10.4
Ras association (RalGDS/AF-6) domain family member 1 10.4
E2F transcription factor 7 10.4
KIAA1797 10.4
PTEN2 10.4
RSL24D1 10.4
CCDC19 10.4
NET-6 10.4
TCEB3C 10.4
inositol-3-phosphate synthase 1 10.4
opioid binding protein/cell adhesion molecule-like 10.4
Kinesin family member 2C 10.4
DFFB 10.4
C17orf91 10.4
NUPL1 10.4
Cytoplasmic FMR1-interacting protein 2 10.4
High mobility group AT-hook 1 10.4
HMGIC/NFIB 10.4
KIAA1391 10.4
TMEM209 10.4
TCBA1 10.4
MCMP 10.4
Migration stimulating factor 10.4
KLHL35 10.4
RAB36 10.4
ZZZ4 10.4
Fragile histidine triad 10.3
dickkopf homolog 4 10.1
TPTE2 10.1
C12orf35 10.1
SEMA4G 10.1
C3orf10 10.1
INPP4B protein 10.1
SPC21 10.1
DLG1 protein 10.1
WW domain-containing protein 1 10.1
serine/threonine kinase 38 10.1
STGC3 10.1
calmodulin binding transcription activator 1 10.1
ING3 protein 10.1
WWC3 10.1
POLR1A 10.1
Keratin, type II cytoskeletal 6B 10.1
MT1K 10.1
USP9X protein 10.1
HKR3 10.1
SLIT2 protein 10.1
ARLTS1 10.1
RAD51C protein 10.1
APRG1 10.1
Kinase suppressor of Ras 1 9.9
kinase suppressor of ras 2 9.8
ZC3HC1 9.8
PTAG 9.8
EWI2 9.8
Rho-associated, coiled-coil containing protein kinase 2 9.8
INT3 9.8
KCNA3B 9.8
AVL9 9.8
TMEM7 9.8
BART1 9.8
ZSCAN18 9.8
interferon-inducible double-stranded RNA-dependent protein kinase 9.8
DERL3 9.8
diadenosine triphosphate hydrolase 9.8
MED12L 9.8
MRPL43 9.8
ARHGAP28 9.8
CDC2L1 9.8
OSRC 9.8
TRAM2 9.8
SYNJ2 9.8
XPO6 9.8
Fucosyltransferase 8 9.8
PHACTR3 9.8
p53-regulated apoptosis-inducing protein 1 9.8
PHGDH protein 9.8
GPR55 protein 9.8
hCLCA4 9.8
STRAD 9.8
STK38L 9.7
BRSK1 9.7
TAPP2 9.7
rap1GAP 9.6
L3MBTL 9.6
ATP5G2 9.6
MO25 9.6
Eaf6 9.6
GNG4 9.6
EIF5B 9.6
ANKRD28 9.6
AT motif-binding factor 1 9.6
PHF20L1 9.6
APM-1 9.6
VILL 9.6
FNIP2 9.5
TAF1C 9.5
H-REV107-1 9.5
MTAP protein 9.5
HLJ1 9.5
PTENP1 9.4
deleted in colorectal carcinoma 9.4
Jumonji domain-containing protein 8 9.4
FSIP2 9.4
xeroderma pigmentosum, complementation group C 9.4
Wiskott-Aldrich syndrome protein family member 3 9.4
MAP/microtubule affinity-regulating kinase 4 9.4
more...
Disease
Neurofibromatosis 1 and 2 (NF1 and NF2) 12.4
Idiopathic ulcerative colitis 10.4
Diffuse Astrocytoma 10.4
skin cancer, basal cell 10.2
Extrahepatic bile duct carcinoma 9.8
Anaplastic ependymoma 9.8
CNC2 9.4
Anaplastic Astrocytoma 9.1
lgl 8.6
HRPT2 8.5
Diffuse astrocytoma 8.5
Small cell osteosarcoma 8.4
medullary breast carcinoma 8.3
FWT1 8.3
Hamartomatous polyps 8.2
BRCAX 8.1
Hairy cell leukemia variant 8.0
Cylindroma 8.0
Multiple cancer 7.9
Ruvalcaba syndrome 7.8
CYLD 7.8
MCC deficiency 7.7
Sticker 7.7
Hippel 7.7
familial cancer 7.7
Macroprolactinomas 7.7
Typical carcinoid 7.6
EXT3 7.6
Tumor morphology 7.5
MSSE 7.5
Enteropathy-associated T-cell lymphoma 7.4
Glandular odontogenic cyst 7.4
FIPA 7.4
benign proliferative breast disease 7.4
Li-Fraumeni syndrome 7.4
Cowden syndrome 7.3
MEN1 7.3
MYH-associated polyposis 7.3
Endometrioid carcinoma 7.2
salivary gland adenoid cystic carcinoma 7.1
3p- syndrome 7.1
EXT2 7.1
NF2 7.0
pancreatic gastrinoma 7.0
Peutz-Jeghers syndrome 7.0
high-risk cancer 6.9
retinoblastoma 6.9
nevoid basal cell carcinoma syndrome 6.8
tylosis 6.8
BLL 6.7
ovarian endometrioid adenocarcinoma 6.7
XPV 6.7
GCB-DLBCL 6.7
Bone sarcomas 6.6
Anaplastic carcinoma 6.6
pseudoglioma 6.6
CM1 6.6
endocrine cancer 6.6
Odontogenic cysts 6.5
Acral lentiginous melanoma 6.5
Colorectal adenocarcinoma 6.5
Schwannomatosis 6.5
Trisomy 12 6.4
DFNA5 6.4
Oculodentodigital dysplasia 6.3
familial adenomatous polyposis 6.3
T-cell prolymphocytic leukemia 6.3
ARF 6.3
Oral Cancer 6.3
Epithelial dysplasia 6.2
Laryngopharyngeal reflux 6.2
FIH 6.2
monosomy 22 6.2
BHD 6.2
Pulmonary lymphangioleiomyomatosis 6.1
multiple endocrine neoplasia 6.1
MDM 6.1
MEN 2 6.1
breast fibroadenoma 6.0
ABC-DLBCL 6.0
HNPCC 6.0
environmental carcinogenesis 6.0
XP-A 6.0
parathyroid hyperplasia 5.9
chronic phase CML 5.9
bilateral breast cancer 5.8
Extraskeletal osteosarcoma 5.8
trisomy 14 5.8
Oral submucous fibrosis 5.8
Trousseau's syndrome 5.8
squamous cell carcinoma of the anus 5.7
intestinal cancer 5.7
gastric mucosal atrophy 5.7
HNSCC 5.7
BHD 5.7
APC 5.6
XPB 5.6
jejunitis 5.6
Necrotic enteritis 5.6
neurofibromatosis 5.6
Lhermitte-Duclos disease 5.5
tumorigenesis 5.5
breast cancer stage 5.5
cancer relapse 5.5
Kidney Cancer 5.5
neurofibromatosis type 1 5.5
Coffin-Siris syndrome 5.5
WT1 5.5
malignant mesothelioma 5.5
recurrent endometrial cancer 5.5
renal cancer 5.5
viral carcinogenesis 5.4
mixed gliomas 5.4
XDP 5.4
Dukes 5.4
PanIN 5.4
adrenal cancer 5.4
MSS 5.4
PLAT 5.4
radiation carcinogenesis 5.4
PNET 5.4
Hepatocarcinogenesis 5.4
polyposis 5.3
high-grade lymphomas 5.3
carcinogenesis 5.3
MCPH1 5.3
human papilloma virus 5.3
human papilloma virus 5.3
premalignant condition 5.3
Turcot syndrome 5.3
neoplastic transformation 5.3
cancer angiogenesis 5.3
relapsed CLL 5.3
Recklinghausen 5.3
Beckwith-Wiedemann syndrome 5.2
enchondromatosis 5.2
MAR 5.2
FRA 5.1
AIP 5.1
tuberous sclerosis 5.1
ATM 5.1
stage II colon cancer 5.1
Epithelioid sarcoma 5.1
AIP 5.1
Squamous Cell Carcinoma 5.1
LGS 5.1
Oral lichen planus 5.0
neoplastic process 5.0
erythroplakia 5.0
Myoepithelial 5.0
Bowen's disease 5.0
Merkel cell carcinoma 5.0
malignant state 5.0
FHL2 5.0
acanthoma 5.0
Proteus syndrome 5.0
Parathyroid carcinoma 5.0
anaplastic astrocytoma 5.0
uveal melanoma 5.0
parapsoriasis 4.9
more...
Symptom
prickling sensation 8.5
male subfertility 4.3
nipple discharge 3.4
nipple discharge 3.3
CSR 3.0
livedo 2.6
DNA marker 2.5
cerebellar ataxia 2.2
skin damage 1.8
cachexia 1.5
starvation 1.5
fever of unknown origin 1.4
masculinization 1.1
paraparesis 1.0
sore throat 1.0
shoulder pain 1.0
ataxia 0.8
colic 0.8
hemiplegia 0.4
pelvic pain 0.4
collapse 0.4
dystonia 0.4
exhaustion 0.2
acute stress 0.2
splenomegaly 0.1
numbness 0.1
lethargy -0.1
flushing -0.3
tinnitus -0.3
arthralgia -0.4
seizures -0.6
dizziness -0.9
insomnia -1.0
thinning -1.1
erythema -1.3
dyspnea -1.4
abdominal pain -1.5
chest pain -1.7
diarrhea -2.4
vomiting -2.6
fatigue -3.3
pain -3.3
anesthesia -3.4
headache -3.4
Drug
Dacogen 7.9
Olomoucine 6.9
Azacytidine 6.8
MDM 6.3
Podophyllum 6.0
TES 5.6
Romidepsin 5.6
Ora 5.4
PNT 5.3
Clofarabine 5.3
ROX 5.2
NLF 5.1
Tranilast 4.7
Verteporfin 4.6
Tarceva 4.6
ETS 4.5
Paraffin 4.5
Thioridazine 4.5
PFT 4.5
CDX 4.4
AGG 4.3
KCL 4.3
Triad 4.1
Triad 4.0
CDX 4.0
Vorinostat 3.9
Gleevec 3.9
Tannic acid 3.8
GEO 3.8
TEL 3.8
CTT 3.7
Vinorelbine 3.7
Ginger 3.5
KGF 3.5
Imatinib 3.4
-deoxyadenosine 3.4
Orphan 3.3
IL-11 3.3
Salicylate 3.3
CED 3.2
Parkin 3.1
Parkin 3.1
R1881 3.1
Everolimus 3.0
OTC 2.9
MDS 2.9
G418 2.8
Erlotinib 2.8
Riboflavin 2.8
Irinotecan 2.7
Activin 2.7
Cetuximab 2.5
GRF 2.5
lysine 2.4
ADM 2.4
CTC 2.3
OTC 2.3
ACT 2.3
DHT 2.3
DMAP 2.2
Retinoic acid 2.2
MRC 2.2
Herceptin 2.2
DHT 2.2
RFP 2.1
CoCl2 2.1
CoCl2 2.1
CTC 2.1
Lovastatin 2.0
IL-1ra 2.0
Alanine 1.9
CTA 1.9
CAM 1.9
Mutagen 1.9
BH4 1.8
Ranitidine 1.8
Taxol 1.7
9-THC 1.6
Gelatin 1.6
PTC 1.6
Award 1.6
TTC 1.5
niacin 1.5
p75 1.5
Spectrum 1.4
DNase I 1.4
uPA 1.3
Propofol 1.3
ROS 1.3
ABC 1.3
MAP 1.3
Asn 1.2
TAT 1.2
ICI 1.0
ENT 0.9
MOF 0.8
PTH 0.7
HCH 0.6
NADH 0.6
ROC 0.5
PCB 0.3
Adriamycin 0.2
CTX 0.1
G-CSF 0.0
Glutathione -0.0
ascorbate -0.1
CSF -0.2
EPA -0.4
caffeine -0.4
IFN-gamma -0.4
Dermatol -0.4
IL-2 -0.4
Spectrum -0.6
THF -0.6
vitamin E -0.7
Ethanol -0.9
ZnO -1.4
Gel -1.5
Dial -2.5
Cardiovasc -5.2
Enzyme
adenylylsulfate-ammonia adenylyltransferase 12.4
EC 3.6.2.1 11.4
ChEH 10.8
STK11 8.0
STK4 8.0
nitric oxide dioxygenase 7.3
Ap4A hydrolase 6.8
methylthioadenosine phosphorylase 6.5
poly(A)-specific ribonuclease 6.5
10-formyltetrahydrofolate dehydrogenase 6.3
ADE2 6.1
protein L-isoaspartyl methyltransferase 6.1
poly(A)-specific ribonuclease 6.0
gluconokinase 5.9
pyruvate dehydrogenase phosphatase 5.9
EC 2.6.1.16 5.9
fumarase 5.7
methylenetetrahydrofolate dehydrogenase 5.6
caspase-2 5.4
caspase-2 5.3
guanidinoacetate methyltransferase 5.3
methylenetetrahydrofolate dehydrogenase 5.2
DNA methyltransferase 5.2
jararhagin 5.1
alpha-N-acetylgalactosaminidase 5.1
oxoglutarate dehydrogenase 5.1
inositol phosphatase 5.0
Omi/HtrA2 5.0
PHD 5.0
phosphoinositide 3-kinase 5.0
APC 4.9
cdc2 4.9
lysine acetyltransferase 4.9
guanylate kinase 4.9
phosphatidylserine decarboxylase 4.8
methionine synthase reductase 4.7
endonuclease VII 4.7
AMP-activated kinase 4.5
histone demethylase 4.5
histone acetyltransferase 4.4
PTPase 4.4
AGT 4.4
AMP-activated protein kinase 4.4
ubiquitin-protein ligase 4.3
AMPK 4.3
biliverdin reductase 4.3
fumarylacetoacetate hydrolase 4.2
p100 4.2
TSA 4.2
protein phosphatase 2A 4.1
prolyl hydroxylase 4.1
phosphoglycerate dehydrogenase 4.1
NAT 4.0
TOR 3.9
proteasome 3.9
nicotinamide phosphoribosyltransferase 3.9
PDK1 3.8
CEP 3.8
triphosphatase 3.8
polo-like kinase 1 3.8
nitrilase 3.8
methionine synthase 3.7
BAT 3.7
aminopeptidase A 3.7
TSP-1 3.7
CGT 3.6
NPL 3.6
methionine synthase 3.6
PARP 3.5
protein kinase 3.4
N-acetylglucosaminyltransferase 3.4
AMPK 3.4
luciferase 3.3
ERK 3.3
calcineurin 3.3
DNA ligase 3.3
DNA ligase 3.3
CEP 3.3
GRK5 3.3
phosphatidylinositol 3-kinase 3.2
succinate dehydrogenase 3.1
hypoxanthine-guanine phosphoribosyltransferase 3.1
glutaminase 3.1
poly(A) polymerase 3.0
neutral sphingomyelinase 3.0
GSK 3.0
caspase-8 3.0
focal adhesion kinase 2.9
IKK 2.9
E-2 2.9
ribonucleotide reductase 2.9
cytosine deaminase 2.8
ribonucleotide reductase 2.8
MEK 2.8
NQO1 2.8
fructose 1,6-bisphosphatase 2.8
TMT 2.8
PAL 2.7
mitogen-activated protein kinase 2.7
m-calpain 2.7
cathepsin D 2.7
PAT 2.7
aspartate transcarbamylase 2.6
isocitrate dehydrogenase 2.6
GRK2 2.6
MDR 2.6
thymidylate synthase 2.6
Pla 2.6
MEKK1 2.5
isocitrate dehydrogenase 2.4
MAP 2.3
topoisomerase 2.3
flavin-containing monooxygenase 2.3
topoisomerase 2.2
RNA polymerase 2.2
Thy1 2.1
thioredoxin reductase 2.1
caspase-3 2.1
lysyl oxidase 2.1
caspase-9 2.1
glutathione S-transferase 2.1
thymidine kinase 2.1
CPS 2.1
alpha-ketoglutarate dehydrogenase 2.1
peroxiredoxin 2.0
reverse transcriptase 2.0
LPL 2.0
demethylase 2.0
PGM 1.9
gamma-glutamylcysteine synthetase 1.9
dihydrofolate reductase 1.9
deoxyribonuclease 1.9
PNGase F 1.8
CPT 1.8
protein kinase C 1.7
ornithine transcarbamylase 1.6
CPT 1.6
glycerol-3-phosphate dehydrogenase 1.6
glycerol-3-phosphate dehydrogenase 1.6
prostaglandin synthetase 1.5
PDE 1.5
cathepsin K 1.5
DNA polymerase 1.5
adenylate kinase 1.5
DCF 1.5
BAL 1.4
cathepsin B 1.4
caspase-1 1.4
methylenetetrahydrofolate reductase 1.3
methylenetetrahydrofolate reductase 1.3
glyceraldehyde-3-phosphate dehydrogenase 1.3
phosphoglycerate kinase 1.3
subtilisin 1.3
CPT 1.2
matrix metalloproteinase 2 1.2
N-acetyltransferase 1.2
TAT 1.2
histidine kinase 1.2
beta-galactosidase 1.1
PKG 1.1
more...
Compound
N-Hydroxy-2-acetylaminofluorene 8.4
Tuberin 7.8
5-Aza-2'-deoxycytidine 7.3
Pheophorbide a 7.1
Pheophorbide a 7.1
DCC 7.0
Microcephalin 6.9
Thiostrepton 6.5
Nitrosamine 6.5
Fusaric acid 6.3
Fusaric acid 6.3
Fusaric acid 6.3
BIF 6.1
TES 6.0
Azoxymethane 6.0
UPP 5.8
Bisulfite 5.8
suberic acid 5.6
NIX 5.6
Piperlongumine 5.6
NOXA 5.4
Gambogic acid 5.3
DLG 5.3
PNT 5.3
Lomefloxacin 5.2
FAP 5.2
FAP 5.2
Xanthohumol 5.1
alpha-Naphthoflavone 5.1
alpha-Naphthoflavone 5.1
alpha-Naphthoflavone 5.0
Temsirolimus 5.0
AICAR 5.0
Sodium bisulfite 5.0
Estrone 4.9
Asbestos 4.9
Withaferin A 4.9
BTG 4.9
5,10-methenyltetrahydrofolate 4.9
BTG 4.9
MNT 4.9
DAC 4.8
GAP 4.8
DEK 4.8
CMK 4.8
Parthenolide 4.7
MGA 4.7
DBD 4.7
Aristolochic acid 4.7
Arecoline 4.7
Mithramycin 4.7
F23 4.6
Calyculin A 4.6
DFS 4.6
Parthenolide 4.5
BAF 4.5
Rottlerin 4.5
Pentamidine 4.4
Geldanamycin 4.4
Rottlerin 4.4
Rottlerin 4.4
PALA 4.4
S 1 4.3
Tetrahydrocannabinol 4.3
Carcinogen 4.2
Cypermethrin 4.2
Letrozole 4.2
AICAR 4.2
Isoform 4.2
TEP 4.2
tetraphosphate 4.1
IDP 4.1
Hesperidin 4.1
TSC 4.1
TET 4.0
TET 4.0
Ubiquitin 4.0
aflatoxin B1 4.0
Histone 4.0
Quinolinic acid 3.9
Ribose 3.9
Histidine 3.9
SCC 3.9
TNM 3.9
Benzo[a]pyrene 3.9
PhIP 3.8
TEL 3.8
MAD 3.7
Serine 3.7
MOD 3.7
1,2-dimethylhydrazine 3.6
THE 3.6
TBP 3.6
NNN 3.6
TCC 3.6
Vincristine 3.6
SAD 3.5
Cannabidiol 3.5
PABA 3.4
Cer 3.4
CAA 3.4
PID 3.4
TBP 3.3
MNU 3.3
PID 3.3
Astaxanthin 3.3
DNA 3.3
DAP 3.3
DAP 3.3
ECS 3.2
C2H2 3.2
Lewis X 3.2
Linoleic acid 3.2
G3P 3.1
MDA 3.1
Vimentin 3.1
ATF 3.1
MNU 3.0
2-oxoglutarate 3.0
threonine 3.0
adenosylmethionine 2.9
urea 2.9
Sevoflurane 2.9
DBH 2.9
hexanoic acid 2.9
Lovastatin 2.9
ATC 2.9
RELA 2.9
SET 2.8
Apigenin 2.8
PTS 2.8
TTC 2.8
Polyamine 2.8
hexanoic acid 2.8
isonicotinic acid 2.8
Epigallocatechin 2.8
ATC 2.8
Sulforaphane 2.8
serine 2.8
PAT 2.8
ENU 2.8
indole-3-carbinol 2.8
25-hydroxycholecalciferol 2.8
DPC 2.8
Riboflavin 2.7
DPC 2.7
MEK 2.7
Gemcitabine 2.7
PGH2 2.7
Gemcitabine 2.7
HCA 2.7
Biotin 2.7
Rapamycin 2.7
folinic acid 2.7
Casein 2.6
AAT 2.6
Suramin 2.6
BCR 2.5
CCC 2.5
3-aminobenzamide 2.5
more...