Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
tumour suppressor 5935
p53 2001
Mol 462
Sep 378
PTEN 233
p16 206
p21 184
phosphatase 141
BRCA1 141
histone 127
ubiquitin 120
MDM2 118
INK4a 115
E-cadherin 113
mutant p53 101
p16INK4a 99
catenin 93
APC 91
adenomatous polyposis coli 87
BRCA2 87
CDKN2A 85
ARF 85
AKT 84
ras 82
cyclin 81
PI3K 80
beta-catenin 79
p73 79
proteasome 78
mTOR 76
Bcl-2 72
cyclin D1 72
pRb 71
proto-oncogene 70
LKB1 68
ATM 68
E3 ubiquitin ligase 67
Mdm2 65
tensin 65
telomeric 62
cytokine 59
lymphoid 58
DCC 55
RB1 52
insulin 50
histone deacetylase 49
c-myc 49
p27 49
cage 48
ubiquitin ligase 47
p14 47
MAPK 46
pVHL 44
cyclin-dependent kinase 44
p63 43
caspase-3 43
ATP 43
p53 target 42
merlin 41
oestrogen receptor 41
EGFR 41
FHIT 40
RASSF1A 40
netrin-1 40
CDK4 39
threonine 39
proliferating cell nuclear antigen 39
neurofibromatosis 38
osteosarcoma 38
ERK 36
HER2 36
KRAS 36
UTR 36
WAF1 36
K-ras 35
NF2 35
WT1 35
c-Myc 35
phosphoinositide 3-kinase 34
AMP-activated protein kinase 34
TSC2 33
E2F1 33
serine/threonine kinase 32
DNA-binding domain 32
p15 32
DNA methyltransferase 32
TGF-beta 32
epidermal growth factor receptor 32
VHL 32
YAP 30
Gen 30
MYC 30
BRAF 30
bcl-2 30
interferon 29
cyclin-dependent kinase inhibitor 29
CIP1 28
vascular endothelial growth factor 28
TSC1 28
tyrosine kinase 28
Chk1 28
Ki-67 27
Li-Fraumeni syndrome 27
androgen receptor 27
p38 27
GTPase 27
AMP 27
E6 protein 26
NMR 26
p300 26
cyclin A 26
SMAD4 26
hMLH1 25
interacting protein 25
cyclin E 25
mdm2 25
PARP 25
DNMT1 25
cancer susceptibility 25
PtdIns 24
protein phosphatase 24
erbB-2 24
transcriptional activator 24
NF1 24
CDH1 24
methylguanine-DNA methyltransferase 24
Pol 24
AMPK 23
SWI 23
neurofibromin 23
cyclin D 23
EGF 23
collagen 23
STK11 23
ERK1 22
transforming growth factor-beta 22
TNM 22
colon carcinoma 22
RET 22
STAT3 22
RAD51 21
MEN1 21
vimentin 21
methyltransferase 21
ataxia telangiectasia mutated 21
progesterone receptor 21
histone H3 21
p15INK4B 21
receptor tyrosine kinase 21
zinc finger 20
cadherin 20
fibronectin 20
cytochrome c 20
LATS1 20
HDM2 19
phosphatidylinositol 3-kinase 19
phosphatase and tensin homolog 19
axonal 19
epidermal growth factor 19
neu 19
more...
Disease
cancer 2634
tumorigenesis 493
carcinogenesis 478
breast cancer 476
carcinoma 344
tumor 308
colorectal cancer 288
retinoblastoma 247
melanoma 201
leukemia 200
lung cancer 178
Hippel 175
metastases 145
prostate cancer 137
squamous cell carcinoma 133
hepatocellular carcinoma 131
ovarian cancer 115
adenocarcinoma 113
renal cell carcinoma 108
gastric cancer 94
APC 93
tumor progression 92
colon cancer 90
ARF 85
ATM 83
adenoma 79
lymphoma 79
glioma 70
WT1 69
neuroblastoma 68
familial adenomatous polyposis 66
acute myeloid leukemia 64
dysplasia 64
glioblastoma 62
NF2 62
pancreatic cancer 60
multiple endocrine neoplasia 60
cervical cancer 57
non-small cell lung cancer 54
MCF 47
bladder cancer 46
skin cancer 44
osteosarcoma 42
neurofibromatosis 41
renal cancer 41
endometrial cancer 38
lung carcinoma 37
polyposis 37
liver cancer 37
Epstein 37
tuberous sclerosis 37
neoplastic transformation 36
myelodysplastic syndrome 35
Melanoma 34
neurofibromatosis type 1 34
mesothelioma 33
epithelial ovarian cancer 32
aggressiveness 32
familial cancer 31
diabetes 31
Li-Fraumeni syndrome 31
thyroid cancer 31
basal cell carcinoma 30
virus infection 30
chronic lymphocytic leukemia 28
oral cancer 28
multiple myeloma 27
MEN1 27
glioblastoma multiforme 25
anemia 24
liver cancer 24
Hodgkin's disease 23
meningioma 23
hepatitis B 23
Peutz-Jeghers syndrome 23
Leukemia 23
malignant mesothelioma 23
suicide 22
nevoid basal cell carcinoma syndrome 22
astrocytoma 22
mole 22
chronic myeloid leukemia 21
Best 21
sarcoma 20
hyperparathyroidism 20
schwannoma 20
Dukes 19
human papilloma virus 19
human papilloma virus 19
B-cell lymphoma 19
PML 19
small cell lung cancer 18
Barrett's esophagus 18
hamartoma 18
Cowden syndrome 18
transitional cell carcinoma 17
non-Hodgkin's lymphoma 17
medulloblastoma 17
Hepatocellular carcinoma 16
mental retardation 16
head and neck cancer 16
Merkel cell carcinoma 16
mental retardation 15
warts 15
infectious diseases 14
fibrosarcoma 14
cirrhosis 14
genetic disorder 14
hepatitis C 14
papilloma 14
carcinoid 13
Infection 13
CYLD 13
carcinoma in situ 13
trisomy 13
SCID 13
ductal carcinoma in situ 13
Alzheimer's disease 13
xeroderma pigmentosum 13
metastatic melanoma 13
obesity 13
cytomegalovirus 12
HCG 12
T-cell acute lymphoblastic leukemia 12
cutaneous melanoma 12
pheochromocytoma 12
Fanconi 11
chondrosarcoma 11
Neuroblastoma 11
EMT 11
Neuroblastoma 11
Glioblastoma 11
papillary thyroid cancer 11
paraganglioma 11
hematologic malignancies 10
B-cell chronic lymphocytic leukemia 10
primary hyperparathyroidism 10
Colorectal Cancer 10
myeloproliferative disorders 10
T-cell lymphomas 10
blast crisis 10
uveal melanoma 9
testicular cancer 9
Beckwith-Wiedemann syndrome 9
chronic lymphocytic leukemia 9
neoplastic process 9
Tumour necrosis 9
HCC 9
MEN 2 9
Lynch syndrome 9
uterine cervix 9
schizophrenia 9
AGS 8
Burkitt's lymphoma 8
cervical intraepithelial neoplasia 8
adrenocortical carcinoma 8
mantle cell lymphoma 8
lgl 8
HRPT2 8
worms 8
more...
Symptom
starvation 13
seizures 10
collapse 7
pain 5
ataxia 5
cachexia 3
exhaustion 3
cerebellar ataxia 3
anesthesia 2
abdominal pain 2
diarrhea 2
dyspnea 2
splenomegaly 2
dystonia 2
nipple discharge 1
paraparesis 1
male subfertility 1
lethargy 1
headache 1
dizziness 1
erythema 1
pelvic pain 1
sore throat 1
masculinization 1
vomiting 1
chest pain 1
DNA marker 1
fatigue 1
nipple discharge 1
hemiplegia 1
tinnitus 1
thinning 1
skin damage 1
arthralgia 1
fever of unknown origin 1
acute stress 1
colic 1
CSR 1
numbness 1
livedo 1
insomnia 1
shoulder pain 1
flushing 1
prickling sensation 1
Drug
lysine 56
Dermatol 36
ETS 11
Paraffin 9
ROS 9
MAP 7
MDM 6
NADH 6
CSF 5
Asn 5
TES 5
Imatinib 5
-deoxyadenosine 4
GEO 4
Mutagen 4
ascorbate 4
DNase I 4
IFN-gamma 4
IL-2 4
ABC 4
Gleevec 4
CAM 4
Parkin 3
MRC 3
ENT 3
Parkin 3
AGG 3
ADM 3
G418 3
Retinoic acid 3
caffeine 3
MDS 3
Spectrum 2
Alanine 2
Triad 2
ROC 2
Podophyllum 2
IL-11 2
Triad 2
ACT 2
Herceptin 2
ICI 2
vitamin E 2
DHT 2
Activin 2
p75 2
Taxol 2
Azacytidine 2
niacin 2
PTH 2
DHT 2
PFT 2
CTX 2
TEL 2
ROX 1
Propofol 1
OTC 1
MOF 1
Gel 1
CDX 1
Cardiovasc 1
KCL 1
Ginger 1
ZnO 1
TTC 1
PNT 1
Dacogen 1
Orphan 1
Ethanol 1
Everolimus 1
Vinorelbine 1
PCB 1
CDX 1
Gelatin 1
uPA 1
Spectrum 1
THF 1
CED 1
Clofarabine 1
CTT 1
Romidepsin 1
Lovastatin 1
Riboflavin 1
Award 1
RFP 1
CTC 1
PTC 1
R1881 1
Olomoucine 1
9-THC 1
Ranitidine 1
KGF 1
Irinotecan 1
Adriamycin 1
TAT 1
Tranilast 1
IL-1ra 1
Salicylate 1
GRF 1
Verteporfin 1
HCH 1
EPA 1
Thioridazine 1
Glutathione 1
Tarceva 1
Erlotinib 1
CoCl2 1
NLF 1
BH4 1
DMAP 1
Cetuximab 1
CTA 1
CoCl2 1
Dial 1
OTC 1
Ora 1
G-CSF 1
Tannic acid 1
Vorinostat 1
CTC 1
Enzyme
ERK 179
protein kinase 162
mitogen-activated protein kinase 118
APC 94
proteasome 78
luciferase 72
focal adhesion kinase 63
AMP-activated protein kinase 50
cdc2 47
phosphoinositide 3-kinase 34
DNA methyltransferase 33
calcineurin 32
RNA polymerase 30
caspase-3 29
PARP 29
protein kinase C 29
AMPK 24
reverse transcriptase 24
MEK 24
STK11 23
AMPK 23
phosphatidylinositol 3-kinase 19
glutathione S-transferase 18
ATPase 18
succinate dehydrogenase 13
fumarase 11
histone acetyltransferase 11
caspase-8 10
GSK 10
protein phosphatase 2A 10
catalase 10
superoxide dismutase 10
topoisomerase 9
DNA polymerase 9
topoisomerase 8
NQO1 8
MAP 7
glutathione peroxidase 7
IKK 7
endonuclease 7
caspase-2 6
PDK1 6
caspase-9 6
thymidine kinase 6
prolyl hydroxylase 6
beta-galactosidase 6
caspase-2 6
DNA ligase 5
PHD 5
DNA ligase 5
cathepsin D 5
peroxidase 5
MDR 5
methylthioadenosine phosphorylase 4
hypoxanthine-guanine phosphoribosyltransferase 4
triphosphatase 4
polo-like kinase 1 4
PTPase 4
urokinase-type plasminogen activator 4
ribonucleotide reductase 4
thymidylate synthase 4
isocitrate dehydrogenase 4
histone demethylase 4
TSA 4
TOR 4
demethylase 4
dihydrofolate reductase 4
ribonucleotide reductase 4
NO synthase 3
caspase-1 3
trypsin 3
glyceraldehyde-3-phosphate dehydrogenase 3
ubiquitin-protein ligase 3
glutaminase 3
p100 3
AGT 3
isocitrate dehydrogenase 3
alanine aminotransferase 3
ADE2 3
aspartate aminotransferase 3
lactate dehydrogenase 3
guanylate kinase 2
adenosine deaminase 2
cathepsin B 2
GRK5 2
DNase 2
ribonuclease 2
RNase 2
MEKK1 2
phospholipase A2 2
chymotrypsin 2
aldehyde dehydrogenase 2
peroxiredoxin 2
ribonuclease 2
AMP-activated kinase 2
CPT 2
RNase 2
subtilisin 2
STK4 2
glutathione reductase 2
CD10 2
thioredoxin reductase 2
Omi/HtrA2 2
CEP 2
prostate-specific antigen 2
kinesin 2
glucose-6-phosphate dehydrogenase 2
TSP-1 2
NAT 2
BAT 2
inositol phosphatase 2
tyrosine hydroxylase 2
lysozyme 2
P-glycoprotein 2
PDE 2
CEP 2
phospholipase C 2
methionine synthase 2
CPT 2
kallikrein 2
PAL 2
adenosine deaminase 2
renin 2
CPT 2
methionine synthase 2
tyrosinase 2
nicotinamide phosphoribosyltransferase 1
PKG 1
poly(A) polymerase 1
ACE 1
endonuclease VII 1
BAL 1
nitrilase 1
deoxyribonuclease 1
neutrophil elastase 1
poly(A)-specific ribonuclease 1
protein L-isoaspartyl methyltransferase 1
lysyl oxidase 1
aldehyde dehydrogenase 1
cathepsin K 1
GRK2 1
transcriptase 1
aldehyde dehydrogenase 1
E-2 1
adenylylsulfate-ammonia adenylyltransferase 1
pyruvate dehydrogenase 1
NPL 1
CaMKII 1
methylenetetrahydrofolate dehydrogenase 1
m-calpain 1
poly(A)-specific ribonuclease 1
pyruvate dehydrogenase phosphatase 1
Ap4A hydrolase 1
oxoglutarate dehydrogenase 1
N-acetylglucosaminyltransferase 1
LPL 1
methylenetetrahydrofolate reductase 1
alpha-ketoglutarate dehydrogenase 1
thrombin 1
glycerol-3-phosphate dehydrogenase 1
more...
Compound
DNA 1512
Dec 435
Clin 161
oxygen 132
urea 91
serine 85
tyrosine 74
lysine 65
arginine 63
threonine 63
DCC 55
ATP 43
glucose 39
MDA 38
calcium 37
zinc 34
phosphate 33
cysteine 32
alanine 30
His 28
AMP 28
proline 24
leucine 24
TNM 22
MTT 22
methionine 21
water 20
NAD 20
iron 18
hydrogen 17
5-Aza-2'-deoxycytidine 17
MEK 16
pyrene 16
NAD 16
retinoic acid 15
Histone 14
aflatoxin B1 14
nitric oxide 14
cAMP 14
GTP 13
Bisulfite 13
TNF 13
Insulin 12
sodium 12
boron 12
adenosylmethionine 12
ADP 12
glutamine 12
Pac 12
ADP 12
ADP 12
acetate 12
pyrimidine 11
2-oxoglutarate 11
pyrimidine 11
GAP 11
Asp 11
tryptophan 11
tryptophan 10
tryptophan 10
tryptophan 10
THE 9
SCC 9
Ubiquitin 8
nitrogen 8
Serine 8
NADPH 8
Phe 8
iodine 8
NADPH 8
glutamate 8
FAP 7
COS 7
MAP 7
vitamin D 7
BCR 7
FAP 7
DDP 7
dUTP 7
5-FU 7
salt 7
ADP-ribose 6
bromide 6
NADH 6
Asbestos 6
NH2 6
ACTH 6
aldosterone 6
DFS 6
H2O2 6
SDS 5
PMA 5
AICAR 5
anthracene 5
CAM 5
formaldehyde 5
TOF 5
aldehyde 5
AICAR 5
Gly 5
TCA 5
TES 5
ABL 5
MDR 5
Estrone 4
Thyroid 4
Rapamycin 4
DBA 4
Cer 4
silver 4
caffeine 4
valine 4
CAT 4
aspartic acid 4
aspartic acid 4
GSH 4
PGA 4
glutamic acid 4
GSH 4
aspartic acid 4
Histidine 4
CAT 4
sulfate 4
Tyrosine 4
Curcumin 4
nicotinamide 4
Ile 4
Vimentin 4
aspartic acid 4
CAT 4
Tamoxifen 3
pentose 3
acetaldehyde 3
acrylamide 3
DBD 3
isoleucine 3
copper 3
SET 3
ATF 3
isoleucine 3
PGE2 3
Mg2+ 3
NOXA 3
CO2 3
pentose 3
DHA 3
tetraphosphate 3
TBP 3
BAF 3
Tamoxifen 3
PMA 3
galactose 3
TTC 3
C2H2 3
PEG 3
Guo 3
pentose 3
N-acetylcysteine 3
BMC 3
Tuberin 3
more...