Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P43146 (
tumour suppressor
)
5,935
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
AMPH1
, an abundant protein in nerve terminals, plays a critical role in the recruitment of dynamin to sites of clathrin-mediated endocytosis. Recently, it is reported to be involved in breast cancer and lung cancer. However, the impact of
AMPH1
on ovarian cancer is unclear. In this study, we used gain-of-function and loss-of-function methods to explore the role of
AMPH1
in ovarian cancer cells.
AMPH1
inhibited ovarian cancer cell growth and cell migration, and promoted caspase-3 activity, resulting in the increase of cell apoptosis. In xenograft mice model,
AMPH1
prevented tumour progression. The anti-oncogene effects of
AMPH1
on ovarian cancer might be partially due to the inhibition of PI3K/AKT signalling pathway after overexpression of
AMPH1
. Immunohistochemistry analysis showed that the staining of
AMPH1
was remarkably reduced in ovarian cancer tissues compared with normal ovarian tissues. In conclusion, our study identifies
AMPH1
as a
tumour suppressor
in ovarian cancer in vitro and in vivo. This is the first evidence that
AMPH1
inhibited cell growth and migration, and induced apoptosis via the inactivation of PI3K/AKT signalling pathway on ovarian cancer, which may be used as an effective strategy.
...
PMID:AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway. 3247 71
