Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the animal kingdom, skin pigmentation is highly variable between species and contributes to phenotype. In humans, the role of skin pigmentation is associated with sun protection. Skin pigmentation depends on the ratio of two pigments, pheomelanin and eumelanin, which are synthetized by a specialized cell population, the melanocytes. In this review, we focused on one factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene involved in the eumelanin synthesis via TYRP1 protein. Counterintuitively, high TYRP1 mRNA expression is associated with a poor clinical outcome for patients with metastatic melanoma. Recently, we explained this unexpected function of TYRP1 by demonstrating that TYRP1 mRNA sequesters microRNA (miRNA)-16, a tumour suppressor miRNA. Here, we focused on actors influencing TYRP1 mRNA abundance, particularly transcription factors, single nucleotide polymorphisms (SNPs) and miRNAs since they dictate the indirect oncogenic activity of TYRP1.
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PMID:Human TYRP1: two functions for a single gene? 3330 5