Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

MicroRNA-128 (miR-128) has been found to be dysregulated and might function as a tumour suppressor in various cancers, including ovarian cancer. However, the underlying mechanism of miR-128 in ovarian cancer has not been fully understood. The miR-128 and homeobox B8 (HOXB8) levels in clinical samples and cultured cell lines were measured using qRT-PCR and/or Western blot analysis. Cell proliferation was assessed using Cell Counting Kit-8 assay. Cell apoptosis was determined using flow cytometry. The association between miR-128 and HOXB8 was confirmed using dual-luciferase reporter assay. Results showed that decreased miR-128 expression and increased HOXB8 expression were observed in ovarian cancer tissues and cell lines. Transfection with miR-128 mimics suppressed the cell proliferation and enhanced paclitaxel sensitivity in ovarian cancer cell lines. miR-128 directly targeted HOXB8 in ovarian cancer cell lines. Knockdown of HOXB8 abolished the effects of miR-128 inhibitor on ovarian cancer cell proliferation and paclitaxel sensitivity. Summarily, miR-128 displayed a tumour suppressor role in ovarian cancer via targeting HOXB8. It is supposed that miR-128 might be effective for targeting therapy for ovarian cancer.
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PMID:MicroRNA-128/homeobox B8 axis regulates ovarian cancer cell progression. 3127 3