Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P43146 (
tumour suppressor
)
5,935
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The characterization of the rare, radiation-sensitive and cancer-prone syndromes, ataxia telangiectasia and
Nijmegen breakage syndrome
, has demonstrated that genetic predisposition increases the risk of developing cancer after exposure to ionizing radiation (IR). Molecular analyses of these disorders provide valuable insights into the normal function of these two gene products in the cellular response to IR-induced DNA damage. Their contribution to a cellular radiosensitive phenotype and their role in sporadic cancers can now be fully assessed. For example, the gene ataxia telangiectasia mutated (ATM) has recently been shown to be a
tumour suppressor
gene in T-cell prolymphocytic leukaemia, and there is increasing evidence that individuals with one mutated ATM or
Nijmegen breakage syndrome
(NBS1) allele have an increased predisposition to cancer.
...
PMID:Radiation, DNA damage and cancer. 1020 48
