Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The expression of tumour suppressor gene P53 products-P53 protein in patients with primary lung cancer has been studied by ABC immunohistochemical method using McAb 1801 as probe. Abnormalities in P53 expression were found in 63 of 78 carcinomas, 23 of 26 squamous cell carcinomas, 23 of 29 adenocarcinomas, 7 of 11 large cell carcinomas, 7 of 9 small cell carcinomas and all 3 cases of adenoid cystic carcinomas showing abnormal P53 expression, whereas no expression of P53 was detectable in 11 normal lung samples. These findings suggest that the pathogenesis of lung cancer may also be related with abnormalities of P53 gene.
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PMID:[The immunohistochemical study of p53 protein in primary lung cancer]. 808 21

Lysyl oxidase (LOX) is the extracellular enzyme that initiates the main pathway of collagen and elastin cross-linking. LOX has also been correlated with the ras recision gene, a putative tumour suppressor isolated from revertants of ras-transformed fibroblasts. The present study investigates the potential correlation of LOX-dependent matrix protein cross-linking in the stromal reaction of lung carcinomas, with reference to the architecture of the main stromal reactions accompanying the neoplastic breast tissues. A strong LOX expression was associated with the hypertrophic scar-like stromal reaction found at the front of tumour progression in squamous carcinomas, adenocarcinomas, large cell carcinomas, or at sites of initial extense in bronchiolo-alveolar carcinomas. In contrast, little or no LOX expression was found within the stromal reaction of invasive carcinomas, small cell carcinomas, and neuro-endocrine carcinomas. The significance of LOX expression and of the stromal reaction are discussed, in light of data that associate LOX expression with tumours displaying a rather good prognosis.
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PMID:Selective expression of lysyl oxidase (LOX) in the stromal reactions of broncho-pulmonary carcinomas. 1100 37