Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recurrent pregnancy loss (RPL) has been associated with low expression of apoptosis-and angiogenesis-related genes. The p53 tumour suppressor gene has been shown to induce apoptosis and angiogenesis. Recently, a low increased frequency of a p53 codon 72 polymorphism has been reported among women experiencing RPL. This study investigated the prevalence of p53 codon 72 polymorphism among women with a history of RPL, to determine whether this polymorphism may serve as a risk factor for miscarriage. Buccal swabs were obtained from 205 women with a history of two or more consecutive spontaneous abortions and 25 women with at least two live births and not more than one elective abortion. DNA was extracted from the buccal swabs and PCR amplification of p53 arginine(Arg)72 and proline(Pro)72 variants was performed. The frequency of homozygous Arg and Pro or heterozygous Arg/Pro genotypes among RPL patients and controls were not significantly different. No significant differences in allelic frequencies of p53 were observed. In addition, the allelic frequencies between controls and those previously reported were the same. It is concluded that p53 codon 72 polymorphisms do not serve as a susceptibility factor affecting the chances of miscarriage in an unselected population.
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PMID:Role of p53 codon 72 polymorphism in recurrent pregnancy loss. 1656 30

Implantation failure is the most frequent cause of lack of pregnancy after IVF and embryo transfer. Successful implantation requires trophoblastic growth into the endometrium to stimulate its own blood supply. The p53 tumour suppressor gene has been shown to regulate cell growth and induce angiogenesis. Therefore, the prevalence of p53 codon 72 polymorphism was investigated among women with a history of recurrent implantation failure to determine whether this polymorphism may serve as a risk factor for implantation failure. DNA was extracted from the buccal swabs obtained from 70 women experiencing implantation failure and polymerase chain reaction amplification of p53 arginine (Arg) 72 and proline (Pro) 72 variants were performed. The frequency of homozygous Arg and Pro or heterozygous Arg/Pro genotypes was compared with frequencies among 205 women experiencing recurrent pregnancy loss and 20 control women. The frequency of Pro72 was significantly higher (P=0.003) among women experiencing recurrent implantation failure compared with women experiencing recurrent miscarriage and with control women. It is concluded that p53 codon 72 polymorphisms may serve as a susceptibility factor affecting the chances of recurrent implantation after IVF or embryo transfer.
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PMID:p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure. 1700 66