Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43146 (tumour suppressor)
 5,935 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG) also known as Csk-binding protein was first fully characterized in 2000. It was initially recognized as a ubiquitously expressed adaptor protein recruiting cytoplasmic C-terminal Src-kinase to the close proximity of plasma membrane-anchored Src-kinases thereby allowing Csk to impose its inhibitory potential on these kinases. A role of PAG was initially seen in negative regulation of immune reactions. Since the year 2000 other Csk-dependent and independent interactions have been discovered and some of them showed anti-oncogenic effects in experiment. According to current opinions, these findings place PAG in a position of tumour suppressor candidate.
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PMID:PAG: a potential tumour suppressor and how it all started. From immune signalling to neoplastic transformation. 1953 91