Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P43026 (
lipopolysaccharide
)
62,215
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A
DP-
r
ibosylation factor-
l
ike GTPase
11
(
ARL11
) is a cancer-predisposing gene that has remained functionally uncharacterized to date. In this study, we report that
ARL11
is endogenously expressed in mouse and human macrophages and regulates their activation in response to
lipopolysaccharide
(
LPS
) stimulation. Accordingly, depletion of
ARL11
impaired both
LPS
-stimulated pro-inflammatory cytokine production by macrophages and their ability to control intracellular replication of
Salmonella.
LPS
-stimulated activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) was substantially compromised in
Arl11
-silenced macrophages. In contrast, increased expression of
ARL11
led to constitutive ERK1/2 phosphorylation, resulting in macrophage exhaustion. Finally, we found that
ARL11
forms a complex with phospho-ERK in macrophages within minutes of
LPS
stimulation. Taken together, our findings establish
ARL11
as a novel regulator of ERK signaling in macrophages, required for macrophage activation and immune function.
...
PMID:ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling. 2961 17
