Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43026 (lipopolysaccharide)
 62,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thermal responses to prazosin (0.75 mg/kg, i.v. as a bolus injection or 3 h infusion) were investigated in febrile rabbits (treated with E. coli lipopolysaccharide, PLPS) at 3 ambient temperatures (Ta) of 5, 19, 28 degrees C. The drug produced antipyresis which increased with the simultaneous drop of Ta. This antipyretic activity was accompanied by an inhibition of heat production or enhanced elimination of heat, depending on Ta. It is suggested that antipyresis produced by prazosin is mainly due to the effector part of the thermoregulatory system.
Acta Physiol Pol 1990
PMID:Antipyretic activity of prazosin. 166 73

Chlormethine (Nitrogen mustard) in small doses proved to have immunopotentiating and anti-inflammatory activities. The influence of two nitrogen mustard derivatives : chlorambucil (1 or 10 micrograms/kg p.o.) and cyclophosphamide (0.03 or 0.3 mg/kg i.v.) as well as busulphan (0.5 or 5 micrograms/kg p.o.)--the agent of ++alkylating cytostatic group were investigated in rabbits. Whole blood count, the number of T and B lymphocytes, serum IgG level, phagocytic and microbicidal activities of neutrophils and the plasma level of free glucocorticoids were estimated. The drugs were used in the doses 10-100 times lower than cytostatic ones. Moreover, the ability of alkylating drugs to enhance or to suppress the changes evoked by lipopolysaccharide of E. coli in examined parameters was assessed. The results were compared with chlormethine data obtained previously. None of two nitrogen mustard derivatives (chlorambucil or cyclophosphamide) in the doses many times lower than cytostatic ones, exhibited an immunostimulating and adjuvant properties characteristic of chlormethine. Such properties did not demonstrate small doses of busulphan, another compound of alkylating drugs.
Pol Arch Weter 1990
PMID:[Immunomodulating effects of low doses of nitrogen mustard derivatives]. 213 53

We investigated the effect of copper-dextran complex (C-79), acetylsalicylic acid (ASA), mefenamic acid (MEFA) and indomethacin (IND), alone or combined with E. coli lipopolysaccharide (LPS) on osmotic fragility of rabbit erythrocytes. It has been found that LPS in combination with ASA, MEFA, and IND did not change the stabilizing effect of the antipyretics on rabbit erythrocyte membrane. C-79 in doses of 0.4-0.8 mg Cu/kg iv stabilized the erythrocyte membrane for several hours. In lower doses, the compound produced a weak stabilizing effect, and an opposite effect was induced by a dose of 1.6 mg Cu/kg. After administration of C-79 and LPS in combination, the duration of LPS-induced fever was shortened and the erythrocyte stabilization by C-79 was weaker. A combination of ASA with C-79 depressed the body temperature in normothermic animals, while the stabilizing effect of both compounds on the erythrocyte membrane was non-additive.
Pol J Pharmacol Pharm
PMID:The influence of copper-dextran complex (C-79), non-steroid anti-inflammatory drugs and bacterial pyrogen on stabilization of rabbit erythrocyte membrane. 241 15

Rabbits were injected with the lipopolysaccharide from E. coli (LPS) and received orally nonsteroid anti-inflammatory drugs (NSAIDs): acetylsalicylic acid, indomethacin, mefenamic acid, ibuprofen, aminophenazone, metamizole sodium, and phenylbutazone. These NSAIDs exerted antipyretic action without inhibiting the increase in the level of plasma glucocorticoids induced by LPS. This finding indicates the lack of correlation between the pyrogenic action of bacterial pyrogen and pyrogenic increase in the plasma glucocorticoid level. The investigated NSAIDs when given alone to normothermic rabbits differently affected the plasma glucocorticoid level: acetylsalicylic acid, indomethacin and ibuprofen depressed the plasma level of these hormones, mefenamic acid and phenylbutazone elevated it, and aminophenazone and metamizole sodium did not alter it significantly.
Pol J Pharmacol Pharm
PMID:Pyrogenic fever and blood plasma glucocorticoids after nonsteroid anti-inflammatory drugs. 307 85

Thermal responses to copper II salicylate (200 mg/kg iv) were investigated in febrile rabbits (treated with E. coli lipopolysaccharide) at 3 ambient temperatures (Ta) of 5, 20, 28 degrees C. The compound produced antipyresis, which unlike that induced by sodium salicylate (200 mg/kg iv), increased with the drop of Ta. This antipyretic activity was accompanied by enhanced heat elimination which became most evident in thermoneutral conditions. The metabolic rate was intensified after treatment with both compounds. Possible mechanisms responsible for copper salicylate antipyresis are discussed.
Pol J Pharmacol Pharm
PMID:Antipyretic activity of copper salicylate. 332 52

We investigated the effect of prazosin on experimental fever induced by E. coli lipopolysaccharide (LPS) and on noradrenaline hyperthermia in the rabbit. LPS and prazosin were administered iv and ivc, noradrenaline was administered only iv. Prazosin inhibited both LPS fever and noradrenaline hyperthermia in a dose-dependent manner. The results indicate the participation of alpha-adrenoceptor in the pyrogen fever and noradrenaline hyperthermia.
Pol J Pharmacol Pharm
PMID:The influence of prazosin on E. coli lipopolysaccharide-induced fever and noradrenaline hyperthermia. 639 69

The effect of sodium salicylate at a dose of 200 and 1000 mg/kg, per os, on body temperature and plasma cation pattern was investigated in healthy rabbits and those infected with 1 microgram/kg iv of lipopolysaccharide Escherichia coli (LPS). An increase in plasma Cu2+ and decrease in Fe2+ and Mg2+ concentration appeared to be the most important effect in LPS treated animals. Sodium salicylate in a dose-dependent manner attenuated the febrile response to LPS. Furthermore, this antipyretic antagonized the rise of Cu2+ concentration induced by pyrogen. Smaller increases of K+ and Mg2+ were observed during antipyresis than in the group of rabbits treated with sodium salicylate alone.
Pol J Pharmacol Pharm 1982
PMID:The plasma cation pattern in fever and sodium salicylate antipyresis. 716 17

The effects of 5,7-dihydroxytryptamine (5,7-DHT) and 6-hydroxydopamine (6-OHDA) on the febrile response to E. coli lipopolysaccharide (LPS) of unanesthetized rats examined. Depleting serotonin (5-HT) in brain with 5,7-DHT produced an attenuation in fever response to LPS, while depleting noradrenaline (NA) content in the preoptic area with 6-OHDA produced an opposite effect. However, 6-OHDA when given intraventricularly (icv) was without any significant effect on fever response to LPS. Presented data indicate that alterations in both noradrenergic and serotoninergic system of the rat brain affect the febrile response response to bacterial pyrogen. Moreover, one might conclude that integrity of noradrenergic neurons in central nervous system (CNS) in the rat is not essential for appearance of pyrogen fever.
Pol J Pharmacol Pharm 1981 Oct
PMID:Effects of 5,7-dihydroxytryptamine and 6-hydroxydopamine on fever response in conscious rats. 732 44

Increased level of Cu2+, induced by intravenous injection of CuCl2 at a dose of 2 mg Cu2+/kg in normothermic and Escherichia coli lipopolysaccharide treated rabbits, enhanced the antipyretic effect of sodium salicylate. Furthermore, in the presence of CuCl2, sodium salicylate caused a fall of body temperature in normothermic rabbits.
Pol J Pharmacol Pharm 1981
PMID:The effect of sodium salicylate on body temperature in normothermic and febrile rabbits with enhanced level of Cu2+. 734 11

Endotoxins are responsible for initiation of septic shock which increases the number of fatalities in Gram-negative bacteremia among hospital patients. The mortality from septic shock is still high despite recent developments in antibiotic therapy because antibiotics are unable to decrease the level of free lipopolysaccharide in the blood stream. Another approach to the treatment and prevention of septicaemia involves stimulation of an immune response against LPS. It was found that immunization with the core structures of endotoxin conjugated with proteins protected animals against infections and endotoxic shock. Anticonjugate sera are of great interest because they are directed against conserved parts of LPS and therefore could have cross-reactive and cross-protective properties with respect to many Gram-negative rods.
Acta Biochim Pol 1995
PMID:Immunotherapy in gram-negative bacterial infections. 765 55


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