Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P43026 (lipopolysaccharide)
 62,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reaction of the microporous metal-organic framework Zn4O(BDC)3 (BDC2- = 1,4-benzenedicarboxylate) with Cr(CO)6 at 140 degrees C in a 6:1 mixture of dibutylether and THF affords Zn4O[(BDC)Cr(CO)3]3 (1). This compound retains the porous cubic structure of the parent framework, but features Cr(CO)3 groups attached in an eta6 fashion to all of the benzene rings. Compound 1 is also microporous, exhibiting a BET surface area of 2130 m2/g. It can be fully decarbonylated by heating at 200 degrees C, but the resulting gray solid (2) shows little affinity for N2 or H2 at 298 K, suggesting aggregation of the chromium atoms. In contrast, photolysis of 1 using 450-nm light in an atmosphere of N2 or H2 produces solids with infrared spectra indicative of Zn4O[(BDC)Cr(CO)2(N2)]3 (3) and Zn4O[(BDC)Cr(CO)2(H2)]3 (4). Under an N2 atmosphere, compound 4 completely converts into compound 3 over the course of 12 h, demonstrating the lability of the Cr0-H2 bond. Owing to isolation of the metal centers within the rigid, evacuable framework structures, the N2- and H2-substituted compounds show greatly enhanced stability relative to molecular analogues generated in frozen gas matrices or supercritical fluid solutions.
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PMID:Matrix isolation chemistry in a porous metal-organic framework: photochemical substitutions of N2 and H2 in Zn4O[(eta6-1,4-benzenedicarboxylate)Cr(CO)3]3. 1815 39

The methanolic extract from the fruit of Piper chaba (Piperaceae) was found to have a hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. From the ethyl acetate-soluble fraction, a new amide constituent named piperchabamide E together with twenty known amide constituents (e.g., piperine, piperchabamides A-D, and piperanine) and two aromatic constituents were isolated as the hepatoprotective constituents. With regard to structure-activity relationships, the amide moiety and the 1,9-decadiene structure between the benzene ring and amide moiety were suggested to be important for strong inhibition of D-GalN/tumor necrosis factor-alpha (TNF-alpha)-induced death of hepatocytes. Furthermore, a principal amide constituent, piperine, dose-dependently inhibited increase in serum GPT and GOT levels at doses of 2.5-10 mg/kg (p.o.) in D-GalN/LPS-treated mice, and this inhibitory effect was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha.
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PMID:Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. 1828 53

The inhibitory effects of 21 resveratrol derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in microglia and their structure-activity relationships were studied. It was found, for the first time, that certain resveratrol derivatives that have 3,5-dimethoxyl groups in the A-ring, such as (E)-4-(3,5-dimethoxystyryl)phenol (pterostilbene, compound 2), or have substituted the B-ring of resveratrol with quinolyl, such as (E)-5-[2-(quinolin-4-yl)vinyl]benzene-1,3-diol (compound 18) and (E)-4-(3,5-dimethoxystyryl)quinoline (compound 19), strongly inhibited NO production. Compounds 2, 18, and 19 reduced LPS-induced protein and mRNA expression of inducible NO synthase (iNOS), but did not display direct NO-scavenging activity up to 30 microM in sodium nitroprusside (SNP) solution. Moreover, compounds 2, 18, and 19 could also significantly inhibit the production of TNF-alpha by LPS-activated microglia. Further studies revealed that compounds 2, 18, and 19 inhibited LPS-induced NO and TNF-alpha production in microglia by blocking IkappaBalpha phosphorylation and degradation. The potent inhibitory effects of compounds 2, 18, and 19 on microglial activation suggest their potential for treatment of neurodegenerative diseases accompanied by microglial activation.
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PMID:Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships. 1851 11

A series of mixed-ligand coordination complexes, namely [Zn(CA)(2)(BIE)] (1), [Zn(OX)(BIE)].H(2)O (2), [Zn(2)(m-BDC)(2)(BIE)(2)] (3), [Cd(m-BDC)(BIE)] (4), [Cd(5-OH-m-BDC)(BIE)] (5), [Zn(5-OH-m-BDC)(BIE)] (6), [Zn(2)(p-BDC)(2)(BIE)(2)].2.5H(2)O (7), [Cd(3)(p-BDC)(3)(BIE)] (8), [Cd(3)(BTC)(2)(BIE)(2)].0.5H(2)O (9) and [Zn(BTCA)(0.5)(BIE)] (10), where CA = cinnamate anion, OX = oxalate anion, m-BDC = 1,3-benzenedicarboxylate anion, 5-OH-m-BDC = 5-OH-1,3-benzenedicarboxylate anion, p-BDC = 1,4-benzenedicarboxylate anion, BTC = 1,3,5-benzenetricarboxylate anion, BTCA = 1,2,3,4-butanetetracarboxylate anion, and BIE = 2,2'-bis(1H-imidazolyl)ether, were synthesized under hydrothermal conditions. In 1, a pair of BIE ligands bridge adjacent Zn(II) atoms to give a centrosymmetric dimer. In 2 and 3, BIE ligands connect Zn(II)-carboxylate chains to form hexagonal honeycomb 6(3)-hcb and square 4(4)-sql layers, respectively. In 4 and 5, m-BDC and 5-OH-m-BDC bridge Cd(II) atoms to give dimeric units, respectively, which are further linked by BIE ligands to form sql nets. In 6, the BIE ligands extend the Zn(II)-carboxylate chains into 2D sinusoidal-like sql nets. The undulated sql nets polycatenate each other in the parallel manner with DOC (degree of catenation) = 2, yielding a rare 2D --> 3D parallel polycatenation net. In 7, the BIE and p-BDC ligands link the Zn(ii) atoms to give a rare 3-fold interpenetrated 3-connected 10(3)-ths net. 8 contains unusual edge-sharing polyhedral rods formed by [Cd(3)(CO(2))(6)] clusters. Each rod is connected by the benzene rings of p-BDC in four directions into a simple alpha-Po topology. In 9, two kinds of different 2D Cd-BTC layers are alternately linked to each other by sharing Cd(ii) centers to form a 3D framework, which is further linked by two kinds of BIE ligand to produce a complicated 3D polymeric structure. 10 possesses a unique (3,4)-connected 3D framework with (8(3))(2)(8(5).10) topology. The structural differences described indicate the importance of carboxylate ligands and metals in the framework formation of coordination complexes. The infrared spectra, thermogravimetric and luminescent properties were also investigated in detail for the compounds.
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PMID:Syntheses, structures and luminescent properties of zinc(II) and cadmium(II) coordination complexes based on new bis(imidazolyl)ether and different carboxylate ligands. 1852 50

In the cobalt(II) coordination polymer poly[[(mu(2)-benzene-1,3-dicarboxylato){mu(2)-1,1'-[2,2'-oxybis(ethane-2,1-diyl)]di-1H-imidazole}cobalt(II)] monohydrate], {[Co(C(10)H(14)N(4)O)(C(8)H(4)O(4))].H(2)O}(n), two crystallographically distinct Co(II) cations are four-coordinated by N(2)O(2) donor sets in distorted tetrahedral geometries. The Co(II) centers are connected by benzene-1,3-dicarboxylate (m-BDC) anions, giving two types of linear chains, which are further joined via meso-helical 1,1'-[2,2'-oxybis(ethane-2,1-diyl)]di-1H-imidazole ligands to yield a thick two-dimensional slab. The compound displays a two-dimensional four-connected 4(2).6(3).8 topology, which is unprecedented in coordination polymers.
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PMID:A novel cobalt(II) coordination polymer with an unusual four-connected 4(2).6(3).8 topology. 1859 75

Photoelectrons emitted from multiply charged anions (MCAs) carry information of the intramolecular Coulomb repulsion (ICR), which is dependent on molecular structures. Using photoelectron imaging, we observed the effects of ICR on photoelectron angular distributions (PAD) of the three isomers of benzene dicarboxylate dianions C6H4(CO2)2(2-) (o-, m- and p-BDC(2-)). Photoelectrons were observed to peak along the laser polarization due to the ICR, but the anisotropy was the largest for p-BDC(2-), followed by the m- and o-isomer. The observed anisotropy is related to the direction of the ICR or the detailed molecular structures, suggesting that photoelectron imaging may allow structural information to be obtained for complex multiply charged anions.
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PMID:Photoelectron angular distribution and molecular structure in multiply charged anions. 1900 94

The 80% aqueous acetone extract from the fruit of Piper chaba (Piperaceae) was found to have hepatoprotective effects on D-galactosamine (D-GalN)/lipopolysaccharide-induced liver injury in mice. From the ethyl acetate-soluble fraction, three new amides, piperchabamides E, G, and H, 33 amides, and four aromatic constituents were isolated. Among the isolates, several amide constituents inhibited D-GalN/tumor necrosis factor-alpha (TNF-alpha)-induced death of hepatocytes, and the following structural requirements were suggested: (i) the amide moiety is essential for potent activity; and (ii) the 1,9-decadiene structure between the benzene ring and the amide moiety tended to enhance the activity. Moreover, a principal constituent, piperine, exhibited strong in vivo hepatoprotective effects at doses of 5 and 10 mg/kg, po and its mode of action was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha.
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PMID:Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides. 1977 95

In the title compound, [La(2)(C(8)H(4)O(4))(2)(C(6)H(4)NO(2))(2)](n), there are two crystallographically independent La centres, both nine-coordinated in tricapped trigonal prismatic coordination geometries by eight carboxylate O atoms and one pyridyl N atom. The La centres are linked by the carboxylate groups of isonicotinate (IN(-)) and benzene-1,2-dicarboxylate (BDC(2-)) ligands to form La-carboxylate chains, which are further expanded into a three-dimensional framework with nanometre-sized channels by La-N bonds. In the construction of the resultant architecture, in tricapped trigonal prismatic coordination geometries by eight carboxylate O atoms and one pyridyl N atom, while the BDC ligands link to four different cations each, displaying penta- and heptadentate chelating-bridging modes, respectively.
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PMID:Poly[bis(mu4-benzene-1,2-dicarboxylato)di-mu3-isonicotinato-dilanthanum(III)]. 1996 29

The impact of nonsteroidal anti-inflammatory drugs (NSAID) on prostaglandin E(2) (PGE(2)) production and cyclooxygenase 2 (COX-2) mRNA expression in bovine whole blood (WB) cultures stimulated by lipopolysaccharide (LPS) was determined, using the blood from six Holstein dairy cattle in various stages of lactation. Peak production of PGE(2) occurred 24 h after LPS stimulation but did not result in detectable concentrations of thromboxane B(2) (TXB(2)). The NSAID indomethacin, aspirin, flunixin meglumine, and 4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzene sulfonamide (PTPBS; celecoxib analogue), along with dexamethasone, were all equally effective in reducing the concentration of PGE(2) in the bovine WB culture supernatants. Bradykinin exhibited peak supernatant concentrations 1 h after LPS stimulation. Dexamethasone and the NSAID used in this study were equally effective at inhibiting bradykinin production. Peak induction of COX-2 mRNA occurred 3 h post-LPS stimulation. However, neither dexamethasone nor any of the NSAID used in this study altered COX-2 mRNA concentrations. In contrast, aspirin, flunixin meglumine, and PTPBS reduced tumor necrosis factor-alpha (TNFalpha) mRNA concentration. These results demonstrate that bovine blood cells respond to NSAID therapy like other mammalian cells with respect to inhibition of PGE(2) production and suppression of TNF mRNA induction, but do not inhibit induction of COX-2 mRNA.
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PMID:Biomarkers of inflammation in cattle determining the effectiveness of anti-inflammatory drugs. 2044 18

Eighty percent (80%) aqueous acetone extract from fruit of Piper chaba (Piperaceae) was found to have a hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. Among the isolates, several amide constituents inhibited D-GalN/tumor necrosis factor-alpha (TNF-alpha)-induced death of hepatocytes, and the following structural requirements were suggested: i) the amide moiety was essential for strong activity; ii) the 1,9-decadiene structure between the benzene ring and the amide moiety tended to enhance the activity. Moreover, a principal constituent, piperine, exhibited strong in vivo hepatoprotective effect at a dose of 5 mg/kg, p.o. and its mode of action was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha.
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PMID:[Search for TNF-alpha sensitivity degradation principles from medicinal foods-hepatoprotective amide constituents from Thai natural medicine Piper chaba]. 2051 56


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