Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P43026 (
lipopolysaccharide
)
62,215
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
3-Phenylthiophene
-based water-soluble copolythiophenes (CPT1) were designed for colorimetric and fluorometric detection of
lipopolysaccharide
(
LPS
). The sensor (CPT1-C) shows a high selectivity to
LPS
in the presence of other negatively charged bioanalytes as well an extreme sensitivity with the detection limit at picomolar level, which is the lowest ever achieved among all synthetic
LPS
sensors available thus far. Significantly, the sensing interaction can be apparently observed by the naked eyes, which presents a great advantage for its practical applications. The appealing performance of sensor was demonstrated to originate from the multiple electrostatic and hydrophobic cooperative interactions, synergetic with signal amplification via the conformational change of the
3-phenylthiophene
-based copolymer main chain. As a straightforward application, CPT1-C is capable of rapidly discriminating the Gram-negative bacteria (with
LPS
in the membrane) from Gram-positive bacteria (without
LPS
).
...
PMID:Copolythiophene-derived colorimetric and fluorometric sensor for visually supersensitive determination of lipopolysaccharide. 2245 59
