Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P43026 (lipopolysaccharide)
 62,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present work the effect of Isoprinosine on the mitogenic responses of T and B lymphocytes has been studied. We have found that Isoprinosine can enhance in vitro the response to Concanavalin A. This enhancement was more apparent in cell cultures showing an initially low blastogenic response. In low responses artificially induced by treatments in vivo with cyclophosphamide, our results indicate that Isoprinosine, administered in vivo, does not enhance the response to Con A of treated mice. However, addition of Isoprinosine (75 micrograms/ml) to cultures of spleen cells from mice previously treated with cyclophosphamide enhanced the suppressed response up to normal levels. Neither in vivo nor in vitro Isoprinosine treatments increased the response of lymphocytes to lipopolysaccharide, but usually inhibited the blastogenesis of B cells.
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PMID:Modulatory effect of isoprinosine on lymphocyte proliferative response under immunodepressive conditions. 619 89

Isoprinosine appeared to potentiate the production of interleukin 1 and interleukin 2 in cultures of lipopolysaccharide stimulated human monocytes and phytohemagglutinin stimulated cultures of blood mononuclear cells respectively at pharmacological drug levels. Administration of the drug in vivo was associated with increased activity of radiation sensitive suppressor T cell activity against immunoglobulin production in pokeweed mitogen stimulated cultures of B and T cells. Addition of isoprinosine to the latter cultures in vitro appeared to enhance immunoglobulin production consistent with inhibition of suppressor cell activity or stimulation of helper activity. It is not clear from these studies whether the contrasting effects of the drug in vitro and in vivo represent different actions of metabolites or alteration of the proportion of lymphocyte subsets in the circulation. Further studies are required to answer these questions and to determine whether the changes persist with long term administration of the drug.
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PMID:Effect of isoprinosine on interleukin 1 and 2 production and on suppressor cell activity in pokeweed mitogen stimulated cultures of B and T cells. 620 22