Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P43026 (lipopolysaccharide)
 62,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effect of 1,25(OH)2D3 and glucocorticoids on production of TNF-alpha by human peripheral blood adherent cells (HPBAC) was investigated. TNF-alpha was measured by ELISA method using monoclonal antibody against human recombinant THF-alpha. Maximal TNF-alpha production by HPBAC was observed in 4 to 8 hr after incubation when these cells were cultured for 24 hr with 10 micrograms/ml lipopolysaccharide (LPS), 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA) and 10(-5) M indomethacin (INDM). When graded concentration of 1,25(OH)2D3 was added to HPBAC in the presence of above stated dose of LPS, TPA and INDM, a significant suppression of TNF-alpha production was first observed at the concentration of 10(-8) M (P less than 0.05). Similar significant suppressive effect was also observed by adding hydrocortisone and dexamethasone at the concentration of 10(-8) M (P less than 0.05) and 10(-7) M (P less than 0.05), respectively. These results may suggest that 1,25(OH)2D3 has the same inhibitory effect on monocyte/macrophage function as glucocorticoids.
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PMID:Suppressive effect of 1,25(OH)2D3, and glucocorticoids on production of tumor necrosis factor-alpha by human peripheral blood adherent cells. 174 43

The effect of in vivo treatment with THF (thymus humoral factor) on the response of mouse lymphocytes to mitogens was investigated. Different preparations of THF were tested by daily i.m. injections into normal mice. Spleen, peripheral lymph node and thymus cells were tested for reactivity to several mitogens at various intervals after initiation of treatment. Our results indicate that the administration of THF to normal mice causes an inhibitory trend in the response of spleen cells to T-cell mitogens. It was found that the response of spleen cells to phytohemagglutinin (PHA) and concanavalin A (Con A) was strongly depressed after 7 days of treatment with 50 micrograms of THF. This was followed by a recovery of the response to normal levels after 14 days of treatment. The response of spleen cells to lipopolysaccharide (LPS) a B-cell mitogen, did not change throughout 14 days of treatmnent with THF. Lymph node cells of THF-treated mice behaved qualitatively in a similar manner to spleen cells, while thymus cells from THF-treated mice showed a significantly increased response to Con A. In contrast to normal mice, the injection of THF into mice with an impaired reactivity to PHA, such as thymectomized mice and tumor-bearing mice, caused an augmentation of the mitogenic response of spleen cells. These results suggest that in vivo administration of THF causes regulatory changes in the lymphocyte reactivity to T-cell mitogens.
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PMID:Regulatory action of THF on T-cell reactivity to mitogens. 696 74

Reaction of the microporous metal-organic framework Zn4O(BDC)3 (BDC2- = 1,4-benzenedicarboxylate) with Cr(CO)6 at 140 degrees C in a 6:1 mixture of dibutylether and THF affords Zn4O[(BDC)Cr(CO)3]3 (1). This compound retains the porous cubic structure of the parent framework, but features Cr(CO)3 groups attached in an eta6 fashion to all of the benzene rings. Compound 1 is also microporous, exhibiting a BET surface area of 2130 m2/g. It can be fully decarbonylated by heating at 200 degrees C, but the resulting gray solid (2) shows little affinity for N2 or H2 at 298 K, suggesting aggregation of the chromium atoms. In contrast, photolysis of 1 using 450-nm light in an atmosphere of N2 or H2 produces solids with infrared spectra indicative of Zn4O[(BDC)Cr(CO)2(N2)]3 (3) and Zn4O[(BDC)Cr(CO)2(H2)]3 (4). Under an N2 atmosphere, compound 4 completely converts into compound 3 over the course of 12 h, demonstrating the lability of the Cr0-H2 bond. Owing to isolation of the metal centers within the rigid, evacuable framework structures, the N2- and H2-substituted compounds show greatly enhanced stability relative to molecular analogues generated in frozen gas matrices or supercritical fluid solutions.
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PMID:Matrix isolation chemistry in a porous metal-organic framework: photochemical substitutions of N2 and H2 in Zn4O[(eta6-1,4-benzenedicarboxylate)Cr(CO)3]3. 1815 39