Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P43026 (
lipopolysaccharide
)
62,215
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The soluble form of the
leukocyte membrane antigen
CD14 is known to increase the sensitivity of endothelial and epithelial cell lines to bacterial
lipopolysaccharide
(
LPS
). This molecule also directly induces cytokine production in monocytes. Here, the effect of sCD14 and
LPS
on the release of IL-6 and IL-8 by human bronchial epithelial cells (HBECs) was studied. Soluble CD14 induced cytokine production both in the presence and absence of
LPS
. In addition, neither sCD14 nor anti-CD14 monoclonal antibody which blocks the interaction of
LPS
with CD14 had any effect on the binding of
LPS
to HBECs. These data suggest that sCD14 may induce the release of IL-6 and IL-8 from HBECs. However, the binding of
LPS
to bronchial epithelium appears to be mediated by CD14-independent mechanisms.
...
PMID:The CD14 molecule participates in regulation of IL-8 and IL-6 release by bronchial epithelial cells. 969 17
