Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P43026 (
lipopolysaccharide
)
62,215
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role played by macrophages in two effects of
lipopolysaccharide
(
LPS
) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6-trinitrophenol (TNP) conjugated with autologous mouse erythrocytes (MRBC-TNP) in the presence of
LPS
. We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a)
LPS
and macrophages from
LPS
-responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([
TNS
] induced by
LPS
in responsive mice) are added. The mitotic response was not restored. The findings suggest that adjuvanticity and mitogenicity represent distinct pathways of B-cell activation by
LPS
, subject to different regulatory mechanisms.
...
PMID:B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production. 30 85
