Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43026 (lipopolysaccharide)
 62,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Shigellosis due to Shigella sonnei is rare among people growing up and living in developing countries; however, infections due to S sonnei becomes more common than those due to S flexneri as societies develop economically. The relation between risk of S sonnei infection and economic development may be explained by the exposure of developing-country populations to Plesiomonas shigelloides. P shigelloides is often found in surface water, and one serotype (serotype 17) possesses a cell-wall lipopolysaccharide identical to that of S sonnei. Thus, exposure to P shigelloides by drinking contaminated water may immunise populations to S sonnei. As economic development occurs, water quality improves and populations become susceptible to S sonnei. Although drinking water has many advantages, immunisation against S sonnei may be one benefit of traditional water sources.
 ...
PMID:Is protection against shigellosis induced by natural infection with Plesiomonas shigelloides? 791 Aug 90

The influence of lipopolysaccharide (LPS) fraction (molecular weight 50-70 kD) of virulent Shigella sonnei on bacterium ability to suppress delayed-type hypersensitivity (DTH) to xenogenic test-antigen in mice has been studied. It is found that single injection of LPS-fraction or bacteria does not inhibit DTH. Intraperitoneal injection of LPS-fraction together with avirulent S. sonnei causes DTH inhibition in mice and at the same time the injection of LPS-fraction together with Staphylococcus or Pseudomonas (extracellular parasites) does not render influence on DTH levels. There is a possibility of LPS-fraction conversion from active to non-active state and back after treatment by trichloracetic acid, phenol or redox system. It is assumed that in Shigella sonnei infection avirulent enteroinvasive bacteria can be involved in immunopathological process due to activity of non-specific fraction of S. sonnei LPS.
 ...
PMID:[The inductive immunosuppressive activity of the nonspecific lipopolysaccharide fraction of virulent Shigella sonnei]. 917 68