Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P43026 (lipopolysaccharide)
 62,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to search for anti-inflammatory agents against autoimmune diseases, we synthesized 4-alkylthio-o-anisidine derivatives possessing antioxidant activity, and tested them for anti-inflammatory activity against the Arthus reaction in mice. Experimental inflammations, including the Arthus reaction, concanavalin A, phorbol ester and pyrophosphate-induced edemas in rats were inhibited by 4-propylthio-o-anisidine, which inhibited autoxidation of rat brain homogenate and suppressed the lipopolysaccharide-induced increase in the plasma malondialdehyde level in mice. An antioxidant may be an effective agent in immune complex type inflammation where active oxygen species play an important role.
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PMID:Synthesis and anti-inflammatory activity of antioxidants, 4-alkylthio-o-anisidine derivatives. 153 26

The course of the inflammatory reaction in the uterus after local or systemic administration of specific or non-specific antigens was studied. The study was carried out on 40 cows, 10-11 weeks after labour and between 6 and 8 days after ovulation. A specific cell-mediated type of reaction was induced by intrauterine challenge with PPD in cows previously vaccinated with M. bovis subcutaneously or by intrauterine administration. A specific inflammatory process of the type of Arthus reaction was induced by intrauterine challenge with C. fetus ssp. veneralis in animals immunized with these bacteria subcutaneously or by intrauterine instillation of these bacteria. A non-specific inflammatory process in the uterus was initiated by one instillation of lipopolysaccharide (LPS) into the left uterine horn. The cells were washed out from the uterus before and 6, 24, 48 and 72 hours after initiation of the specific or non-specific inflammatory process. The per cent proportions of various cell types were determined. It was demonstrated that intrauterine instillation of specific or non-specific antigens in cows caused a significant rise in PMNs per cent in relation to the control group.
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PMID:Immunological induction of endometritis-model investigations in cows. 211 51

The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. A single intravenous (IV) injection of endotoxin (bacterial lipopolysaccharide [LPS]) produced a mild acute iridocyclitis. Repeated daily (five to seven days) IV injections of LPS (5 micrograms extracted from Salmonella typhimurium) led to a state of refractoriness or LPS "tolerance," and ocular inflammation was no longer produced. In contrast to controls, in rabbits tolerant to LPS, IV LPS failed to elevate prostaglandin E2, thromboxane B2, or chemotactic factors in the aqueous humor. Rabbits tolerant to LPS also resisted the increase in vascular permeability normally induced by an ocular reversed passive Arthus reaction. These results demonstrated that LPS tolerance can induce anti-inflammatory effects in the eye.
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PMID:Lipopolysaccharide tolerance inhibits eye inflammation. I. Reduced immune complex or lipopolysaccharide effects. 315 78

The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
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PMID:Lipopolysaccharide tolerance inhibits eye inflammation. II. Preliminary studies on the mechanism. 315 79

A 50% ethanolic extract of Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae) leaves (PKLE) was found to stimulate the cell-mediated and humoral components of the immune system as well as phagocytosis in experimental animals. PKLE elicited a dose-related increase in SRBC, induced 4 h (early) and 24 h (delayed) hypersensitivity reactions in mice and rats, and horse serum induced Arthus reaction in guinea pigs. It also enhanced the humoral immune responses in mice and rats and phagocytic function of the cells of the reticuloendothelial system in mice. PKLE exhibited no mitogenic activity but augmented the responsiveness of murine splenocytes to T cell mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A) and B cell mitogen lipopolysaccharide (LPS E. coli).
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PMID:Immunostimulatory activity of Picrorhiza kurroa leaf extract. 817 58