Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P42574 (caspase-3)
 45,978 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-3 45978
Bcl-2 9955
caspase-9 5818
cytochrome c 5073
p53 4298
Mol 4112
caspase-8 3908
PARP 3807
Sep 2935
annexin V 2173
TNF 2033
p38 1975
Fas 1899
tumor necrosis factor 1785
superoxide dismutase 1726
GSH 1600
JNK 1447
p21 1437
ROS 1415
PI3K 1292
MAPK 1291
poly(ADP-ribose) polymerase 1285
endoplasmic reticulum 1284
AKT 1253
catalase 1245
cytokine 1159
lactate dehydrogenase 1146
ERK 1138
ATP 1109
ERK1 1103
cytochrome 1068
IL-6 1028
bcl-2 962
mTOR 912
inducible nitric oxide synthase 831
cyclin D1 831
Bid 810
survivin 797
glutathione peroxidase 785
poly (ADP-ribose) polymerase 777
insulin 769
c-Jun 749
LC3 735
p65 708
proliferating cell nuclear antigen 703
lipopolysaccharide 686
bax 683
anti-apoptotic protein 671
BAX 637
SOD 611
calpain 567
XIAP 563
LDH 552
Mcl-1 541
collagen 526
proteasome 512
extracellular signal-regulated kinase 511
Bak 504
kit 503
FasL 482
vascular endothelial growth factor 482
Fas ligand 481
p27 480
Bax protein 469
protein kinase B 457
heme oxygenase-1 454
TNF-alpha 439
apoptosis-inducing factor 436
Nrf2 432
CHOP 430
inhibitor of apoptosis 429
ADP 423
phosphatidylinositol 3-kinase 419
PARP-1 415
pro-apoptotic protein 403
Ki-67 401
catenin 401
mitogen-activated protein 397
COX-2 392
glial fibrillary acidic protein 389
cyclooxygenase-2 388
STAT3 386
TdT 379
MMP-9 377
Apaf-1 374
CA1 373
histone 371
CCK 371
VEGF 369
p38 mitogen-activated protein kinase 368
p62 367
ubiquitin 358
GRP78 353
erythroid 350
interleukin-6 350
osteosarcoma 349
Beclin-1 343
CD95 340
GSK 339
brain-derived neurotrophic factor 338
myeloperoxidase 337
TRAIL 336
IL-10 335
cyclin B1 333
MEK 327
aspartate aminotransferase 326
alanine aminotransferase 325
PC-3 319
Bcl-X 317
nitric oxide synthase 314
cyclin 312
HO-1 311
IFN 305
CPP32 301
LPS 300
tyrosine kinase 300
Smac 291
cyclin E 285
matrix metalloproteinase 285
HSP70 278
tumor necrosis factor alpha 275
H2AX 275
histone deacetylase 273
TLR4 269
AIF 255
amyloid precursor protein 255
FADD 250
C/EBP homologous protein 250
antioxidant enzyme 249
PTEN 248
PKC 247
IL-8 247
interferon 242
E-cadherin 242
BCL2 235
proteasome inhibitor 234
phosphoinositide 3-kinase 233
CD4 232
MMP-2 229
cyclin A 228
DR5 227
ATPase 226
c-Myc 222
CDK4 221
CAT 219
estrogen receptor 216
X-linked inhibitor of apoptosis protein 212
CDK2 212
NMR 211
Tumor necrosis factor 211
CD8 210
epidermal growth factor receptor 207
AMPK 205
phosphatase 204
DIABLO 201
creatine kinase 201
JNK1 200
tyrosine hydroxylase 192
Cytochrome c 190
PERK 190
more...
Disease
cancer 9401
tumor 5993
ischemia 2002
GSH 1601
breast cancer 1495
tumor growth 1455
leukemia 1424
carcinoma 1298
hepatocellular carcinoma 1273
Alzheimer's disease 1116
MCF 1016
diabetes 973
B-cell lymphoma 968
neuroblastoma 862
colon cancer 842
lung cancer 841
prostate cancer 753
Parkinson's disease 741
stroke 727
cerebral ischemia 686
adenocarcinoma 668
melanoma 643
colorectal cancer 597
carcinogenesis 590
tumorigenesis 555
glioma 540
gastric cancer 482
lymphoma 474
ovarian cancer 444
squamous cell carcinoma 432
osteosarcoma 393
cervical cancer 381
non-small cell lung cancer 367
glioblastoma 365
myocardial ischemia 345
liver cancer 325
pancreatic cancer 318
sepsis 315
multiple myeloma 309
hyperglycemia 306
sepsis 306
tumor progression 295
myocardial infarction 295
atherosclerosis 295
acute promyelocytic leukemia 273
acute myeloid leukemia 266
cognitive impairment 263
DDP 253
liver cancer 250
heart failure 235
chronic myeloid leukemia 225
type 2 diabetes 214
lung carcinoma 213
bladder cancer 208
obesity 203
virus infection 202
pheochromocytoma 197
HIV 194
ATM 189
hypertension 182
retinoblastoma 181
depression 178
osteoarthritis 176
cold 166
metastases 166
dementia 165
MTS 162
cardiovascular disease 158
rheumatoid arthritis 151
amyotrophic lateral sclerosis 147
AGS 146
Blocking 144
memory impairment 144
Huntington's disease 144
diabetic nephropathy 143
epithelial ovarian cancer 143
infectious diseases 141
acute lymphoblastic leukemia 138
skin cancer 137
FAS 131
subarachnoid hemorrhage 131
brain edema 131
liver fibrosis 131
SCID 131
renal disease 127
epilepsy 126
solid tumor 125
plaque 123
renal cell carcinoma 122
glioblastoma multiforme 118
Leukemia 115
oral cancer 114
Hepatocellular carcinoma 113
renal ischemia 111
colitis 111
NAME 111
cardiomyopathy 109
diabetic retinopathy 107
immunodeficiency 105
osteoporosis 105
cerebral infarction 105
Infection 104
multiple sclerosis 98
brain tumor 98
esophageal cancer 97
type 1 diabetes 96
CEM 96
herpes simplex 94
Melanoma 94
TEM 93
Osteosarcoma 91
myeloid leukemia 91
Osteosarcoma 91
Pineal 89
chronic lymphocytic leukemia 89
asthma 88
hepatitis 87
encephalopathy 86
esophageal cancer 86
arthritis 85
acute myocardial infarction 85
liver disease 84
TEM 84
fatty liver 83
chronic lymphocytic leukemia 80
inflammatory bowel disease 77
muscular atrophy 75
NOD 74
infertility 74
diabetic cardiomyopathy 74
endometrial cancer 74
status epilepticus 74
SDS 73
sarcoma 72
coronary artery disease 70
influenza 70
insulinoma 69
glaucoma 67
Neuroblastoma 66
Neuroblastoma 66
tuberculosis 66
anemia 66
AIDS 65
myelodysplastic syndrome 65
Glioblastoma 65
Evans 64
chronic obstructive pulmonary disease 64
cirrhosis 63
parkinsonism 62
Hodgkin's disease 62
SEM 62
neuropathy 62
primary tumor 62
systemic lupus erythematosus 61
autoimmune disease 61
proteinuria 60
Mycobacterium 60
suicide 60
HCC 60
tumor angiogenesis 59
more...
Symptom
collapse 307
seizures 201
starvation 190
functional recovery 169
anesthesia 148
pain 142
hypothermia 99
hyperoxia 83
diarrhea 72
respiratory distress 48
weakness 39
memory loss 36
thinning 33
ataxia 28
skin damage 25
cachexia 22
tremor 20
exhaustion 20
fatigue 18
bradykinesia 17
acute stress 17
acidity 13
vomiting 12
neurological disability 11
analgesia 10
dry eye 10
HSA 10
angina 9
Anoxia 9
overweight 9
headache 9
low back pain 9
abdominal pain 8
erythema 8
incoordination 8
nausea 8
hypercapnia 8
cough 7
Neuropathic pain 7
Scratch 6
cerebellar ataxia 6
insomnia 6
anorexia 6
dystonia 6
back pain 6
dyspnea 5
spasticity 5
splenomegaly 5
dizziness 5
sore throat 4
constipation 4
hypotonia 4
stomach pain 4
chorea 4
POA 4
menopausal symptoms 3
chest pain 3
vertigo 3
loss of balance 3
tachypnea 3
Tenderness 3
hepatomegaly 3
hepatosplenomegaly 3
nausea and vomiting 3
forgetfulness 2
acute pain 2
lethargy 2
bitter taste 2
agitation 2
exertional dyspnea 2
physical appearance 2
startle reaction 2
nasal discharge 2
Decreased activity 2
infant diarrhea 2
pelvic pain 2
despair 2
ophthalmoplegia 2
tinnitus 2
male subfertility 2
arthralgia 2
polyuria 2
disturbed balance 2
halitosis 2
Motor dysfunction 2
joint stiffness 2
hemiplegia 2
twitching 2
impaired motor coordination 2
microbial colonization 1
discomfort 1
bone pain 1
Behavioral symptoms 1
hot flushes 1
urinary frequency 1
decreased appetite 1
neuralgia 1
sinus congestion 1
colic 1
breast hyperplasia 1
hypocapnia 1
ataxic gait 1
discomfort 1
catatonia 1
peri-menopausal 1
eds 1
Circling 1
spasm 1
paraparesis 1
Joint hypermobility 1
numbness 1
loss of taste 1
chronic constipation 1
clubbing 1
limb pain 1
abiotrophy 1
neurological pain 1
myoclonus 1
Ear swelling 1
pallor 1
DNA marker 1
sleepiness 1
motor symptom 1
anosmia 1
hyperemesis 1
tonic-clonic seizure 1
otalgia 1
blurred vision 1
abnormal gait 1
Chronic pelvic pain syndrome 1
ketonuria 1
masculinization 1
asthenia 1
loss of equilibrium 1
heartburn 1
stigma 1
myalgia 1
cancer pain 1
Inflammatory pain 1
abdominal cramps 1
not coping 1
muscle rigidity 1
personality change 1
distraction 1
hyperesthesia 1
Drug
ROS 1415
Monit 186
ascorbate 156
MAP 153
vitamin E 142
lysine 137
Dermatol 130
IL-2 122
IFN-gamma 119
Cardiovasc 113
Ethanol 110
Arsenic trioxide 95
Glutathione 75
CSF 74
p75 74
AMC 73
Taxol 67
caffeine 64
TTC 63
CTX 56
Indomethacin 55
ICI 54
Bortezomib 54
MRC 49
Simvastatin 49
ZnO 48
NADH 46
Sorafenib 46
Heme 44
Glycyrrhiza 43
EE2 43
Etoposide 42
Fluorescein 42
Propofol 42
Imatinib 41
TAT 40
CED 40
Angiotensin II 39
Adriamycin 38
ADR 38
Ginseng 36
Parkin 34
Parkin 34
Emodin 34
Emodin 34
NVP 32
Docetaxel 31
CPT-11 30
ADM 30
Mutagen 30
Vitamin E 30
CoCl2 26
CoCl2 26
Leaf 25
-deoxyadenosine 25
PFT 25
Gefitinib 24
Rutin 24
ALA 24
Nitric Oxide 23
lactose 23
3-Methyladenine 23
CTX 23
CTX 23
Epigallocatechin 22
Oxaliplatin 22
Lovastatin 22
Phosphatidylserine 20
Gel 20
Retinoic acid 19
Portal 19
BH4 19
Photofrin 19
DNase I 19
CCL 19
IFN-beta 18
EPA 18
Rosiglitazone 17
Propidium 17
TiO2 17
VCR 17
Silica 17
Ouabain 17
Liraglutide 16
Glucagon 16
G-CSF 16
NBT 16
VCR 16
Fluorescein 15
Flavopiridol 15
Bifidobacterium 15
ABC 15
Gleevec 15
citric acid 14
Asn 14
CAM 14
Paraffin 13
Sodium nitroprusside 13
Ginger 13
Rituximab 13
Fragment 13
Myricetin 12
uPA 12
Kainic acid 12
Dasatinib 12
Herceptin 12
MDM 12
Fraction 12
RFP 12
2-Methoxyestradiol 12
Tannic acid 12
CA-074 11
Zoledronic acid 11
Activin 11
Colistin 11
Pravastatin 11
Albumin 11
Vitamin K 11
Ulinastatin 11
Erlotinib 11
Cilostazol 11
Nephron 11
GHRP 10
Triclosan 10
GEO 10
Fipronil 10
Cetuximab 10
Vorinostat 10
ETS 10
AraC 10
Areca 9
Forskolin 9
Rosuvastatin 9
Growth hormone 9
Histamine 9
niacin 9
Artesunate 9
TAK 9
Growth hormone 9
DEX 9
Troglitazone 9
Rasagiline 9
Zoledronic acid 8
Vitamin A 8
Estrogens 8
Pilocarpine 8
ROC 8
G418 8
PCP 8
Lenalidomide 8
Asthma 8
Hyperforin 8
Itraconazole 8
Donepezil 8
Raloxifene 8
Tacrolimus 8
TAC 8
DHT 8
Everolimus 7
Finasteride 7
more...
Enzyme
caspase-3 35429
caspase-9 4758
mitogen-activated protein kinase 4383
PARP 4192
caspase-8 3145
superoxide dismutase 2288
ERK 1605
catalase 1443
protein kinase 1371
lactate dehydrogenase 1181
glutathione peroxidase 795
caspase-1 679
luciferase 577
focal adhesion kinase 573
alanine aminotransferase 572
protein kinase C 555
caspase-7 539
caspase-7 538
proteasome 521
MEK 504
aspartate aminotransferase 497
peroxidase 422
phosphatidylinositol 3-kinase 419
GSK 378
AMP-activated protein kinase 347
cdc2 330
caspase-2 292
caspase-2 289
NADPH oxidase 272
creatine kinase 260
NADPH oxidase 252
ATPase 242
caspase-6 241
caspase-6 235
phosphoinositide 3-kinase 233
TdT 227
AMPK 220
glutathione S-transferase 214
AMPK 205
tyrosine hydroxylase 191
NO synthase 182
calcineurin 181
glutathione reductase 177
alkaline phosphatase 177
AST 172
complex I 170
acetylcholinesterase 164
cathepsin B 160
MPP 158
P-glycoprotein 153
MMP 150
topoisomerase 147
granzyme B 141
topoisomerase 136
heme oxygenase 127
MAP 119
ACS 117
reverse transcriptase 115
collagenase 115
IKK 110
NQO1 105
cathepsin D 102
caspase-4 98
NOS 96
endonuclease 95
thrombin 87
caspase-4 85
m-calpain 77
trypsin 74
phospholipase C 74
phosphodiesterase 73
phospholipase A2 71
succinate dehydrogenase 70
mu-calpain 70
Omi/HtrA2 67
DNase 66
xanthine oxidase 66
RNA polymerase 62
caspase-10 60
caspase-10 59
glyceraldehyde-3-phosphate dehydrogenase 59
renin 57
RNase 57
RNase 56
cytochrome oxidase 53
thioredoxin reductase 50
APC 50
CAD 48
DNA ligase 48
DNA ligase 48
CAD 48
CAD 48
glyceraldehyde-3-phosphate dehydrogenase 47
MEKK1 47
PDK1 45
protein phosphatase 2A 44
beta-galactosidase 44
cholinesterase 43
DCF 42
ornithine decarboxylase 42
TAT 40
glyceraldehyde-3-phosphate dehydrogenase 40
glyceraldehyde-3-phosphate dehydrogenase 40
glyceraldehyde-3-phosphate dehydrogenase 40
monoamine oxidase 40
urokinase-type plasminogen activator 38
neutral sphingomyelinase 38
lipoxygenase 37
choline acetyltransferase 37
caspase-11 36
MIP 36
caspase-11 36
MMP-3 35
cathepsin L 35
transcriptase 35
gamma-glutamyl transpeptidase 34
acid phosphatase 33
thymidine kinase 33
ACE 33
MDR 32
DNA methyltransferase 31
guanylate cyclase 31
gamma-glutamylcysteine synthetase 31
aconitase 31
matrix metalloproteinase 9 30
CaMKII 30
lysozyme 30
HSD 29
aldehyde dehydrogenase 28
ricin 28
peroxiredoxin 28
paraoxonase 27
matrix metalloproteinase 2 27
DNA polymerase 26
ATP synthase 26
tissue plasminogen activator 26
CPT 26
hexokinase 24
PKG 24
CD10 24
tyrosinase 23
elastase 23
transglutaminase 23
farnesyltransferase 22
neuraminidase 22
aldehyde dehydrogenase 22
adenylate cyclase 22
firefly luciferase 21
aldehyde dehydrogenase 21
aldehyde dehydrogenase 21
thymidylate synthase 21
glutamine synthetase 21
neutrophil elastase 21
sphingosine kinase 21
aldehyde dehydrogenase 21
glucose-6-phosphate dehydrogenase 21
CPT 20
chymotrypsin 20
myosin light chain kinase 20
farnesyltransferase 20
more...
Compound
DNA 8418
oxygen 6343
Dec 3253
MTT 2915
TNF 2033
glucose 1729
GSH 1639
GSH 1639
dUTP 1594
calcium 1382
water 1308
nitric oxide 1177
MDA 1167
iodine 1126
cysteine 1125
ATP 1109
hydrogen 930
bromide 870
ADP-ribose 804
Asp 792
Clin 763
sodium 760
N-acetylcysteine 634
glutamate 574
H2O2 573
ethanol 535
ADP 489
serine 487
nitrogen 461
alanine 460
creatinine 445
tyrosine 438
ADP 424
ADP 423
urea 415
DDP 381
zinc 362
phosphate 350
iron 334
MEK 308
Curcumin 303
Hoechst 33342 298
acetate 296
arginine 294
galactose 285
acridine 276
threonine 261
Cyt 258
ADR 250
Adriamycin 250
Neuronal 248
cadmium 227
retinoic acid 225
cAMP 222
CAT 219
CAT 219
CAT 219
potassium 209
copper 207
Resveratrol 197
selenium 193
sulfate 191
aldehyde 191
Cytochrome c 190
lysine 188
boron 186
NAD 183
NH2 183
aldehyde 183
diacetate 176
Panam 172
THP 169
THP 169
8-OHdG 163
MTS 162
fluorine 159
MPP 158
MPP 158
leucine 154
NAD 152
GSSG 150
PEG 149
Melatonin 147
Quercetin 146
methionine 142
nicotinamide 142
silver 136
salt 134
DMSO 134
ethyl acetate 134
NMDA 133
Pac 129
manganese 128
TEM 126
MAP 122
Cardiol 122
ACS 117
ACS 117
Insulin 117
His 116
AMP 116
palmitic acid 115
5-FU 115
methanol 113
PEG 111
Cereb 109
MPTP 109
aspartic acid 107
Hematoxylin 102
STZ 100
cobalt 99
CO2 98
Retinal 98
ATF 94
Phe 93
aspartic acid 93
cGMP 91
glutamine 90
PGE 90
UTP 90
aspartic acid 90
aspartic acid 90
H2S 89
kaempferol 86
VP-16 86
Glutamate 85
anthracene 84
homocysteine 84
nitrate 83
NADPH 82
NADPH 82
chalcone 81
pyrrolidine 80
pyrimidine 79
Berberine 77
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 76
gallic acid 76
pyrimidine 75
SDS 75
hexane 74
dATP 74
APAP 74
DPPH 72
pyrrolidine 71
Paclitaxel 71
palmitic acid 70
Gly 68
naphthoquinone 68
ammonium 67
naphthoquinone 66
naphthoquinone 66
H2S 66
naphthoquinone 66
pyridine 66
naphthoquinone 66
naphthoquinone 66
naphthoquinone 66
Ang II 66
Metformin 65
Metformin 65
more...