Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42574 (
caspase-3
)
45,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lipotoxicity resulting from a high concentration of saturated fatty acids is closely linked to development of insulin resistance, as well as apoptosis in skeletal muscle.
CTRP5
, an adiponectin paralog, is known to activate AMPK and fatty acid oxidation; however, the effects of
CTRP5
on palmitate-induced lipotoxicity in myocytes have not been investigated. We found that globular domain of
CTRP5
(gCTRP5) prevented palmitate-induced apoptosis and insulin resistance in myocytes by inhibiting the activation of
caspase-3
, reactive oxygen species accumulation, and IRS-1 reduction. These beneficial effects of gCTRP5 are mainly attributed to an increase in fatty acid oxidation through phosphorylation of AMPK. These results provide a novel function of
CTRP5
, which may have preventive and therapeutic potential in management of obesity, insulin resistance, and type 2 diabetes mellitus.
...
PMID:CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. 2519 18
