Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42574 (
caspase-3
)
45,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
:
F-box/WD repeat-containing protein 5
(
FBXW5
) is a member of the FBXW subclass of F-box proteins. Despite its known function as a component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, the role of
FBXW5
in gastric cancer tumorigenesis and metastasis has not been investigated. The present study investigates the role of
FBXW5
in tumorigenesis and metastasis, as well as the regulation of key signaling pathways in gastric cancer; using in-vitro
FBXW5
knockdown/overexpression cell line and in-vivo models. In-vitro knockdown of
FBXW5
results in a decrease in cell proliferation and cell cycle progression, with a concomitant increase in cell apoptosis and
caspase-3
activity. Furthermore, knockdown of
FBXW5
also leads to a down regulation in cell migration and adhesion, characterized by a reduction in actin polymerization, focal adhesion turnover and traction forces. This study also delineates the mechanistic role of
FBXW5
in oncogenic signaling as its inhibition down regulates RhoA-ROCK 1 (Rho-associated protein kinase 1) and focal adhesion kinase (FAK) signaling cascades. Overexpression of
FBXW5
promotes in-vivo tumor growth, whereas its inhibition down regulates in-vivo tumor metastasis. When considered together, our study identifies the novel oncogenic role of
FBXW5
in gastric cancer and draws further interest regarding its clinical utility as a potential therapeutic target.
...
PMID:FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway. 3121 5
