Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42574 (
caspase-3
)
45,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have designed a novel peptide,
TK3
, composed of three functional domains, a protein transduction domain, a TAT followed by three tandem repeats of a proapoptotic peptide, and a
caspase-3
cleavage site, (KLAKLAK)(2)-DEVD.
TK3
was able to transduce into cells and then activate
caspase-3
, which in turn cleaved
TK3
to release additional (KLAKLAK)(2) peptides. (KLAKLAK)(2) was well transduced by TAT into tumor cells and was able to induce apoptosis in vitro and in vivo.
TK3
also induced apoptosis and inhibited angiogenesis in endothelial cells. Further, direct injection of
TK3
into established B16F10 melanoma tumors in C57BL/6 mice resulted in almost complete inhibition of the tumor growth. These results suggest that
TK3
could be beneficial for the treatment of accessible tumors and used as an adjuvant for cancer therapy.
...
PMID:Antitumor effect of a transducible fusogenic peptide releasing multiple proapoptotic peptides by caspase-3. 1856 22
