Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42574 (
caspase-3
)
45,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is known that mammalian
rpS3
functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of
rpS3
, induction of apoptosis. The localization of green fluorescent protein (GFP)-
rpS3
is changed to the nuclear membrane when lymphocytic cells undergo
rpS3
-induced apoptosis. Transient expression of GFP-
rpS3
activates caspase-8/
caspase-3
and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of
rpS3
, DNA repair and apoptosis, use independent functional domains.
...
PMID:RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis. 1498 2
