Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42574 (
caspase-3
)
45,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To determine the contribution of the endoplasmic reticulum (ER) to cell fate decision, we focused on
BRI3-binding protein
(
BRI3BP
) residing in this organelle.
BRI3BP
, when overexpressed, augmented the apoptosis of human embryonic kidney 293T cells challenged with drugs including the anti-cancer agent etoposide. In contrast, the knockdown of
BRI3BP
reduced the drug-triggered apoptosis.
BRI3BP
overexpression enhanced both mitochondrial cytochrome c release and
caspase-3
activity in etoposide-treated cells. In response to etoposide, the ER reorganized into irregularly shaped lamellae in mock-transfected cells, whereas in
BRI3BP
-overexpressing cells, such reorganization was not observed. These observations suggest that
BRI3BP
is involved in the structural dynamics of the ER and affects mitochondrial viability. Taken together,
BRI3BP
, widely expressed in animal cell types, seems to possess a pro-apoptotic property and can potentiate drug-induced apoptosis.
...
PMID:Augmentation of drug-induced cell death by ER protein BRI3BP. 1776 69
