Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42574 (
caspase-3
)
45,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The third subunit of the COP9 signalosome (
COPS3
) is associated with cell proliferation and tumorigenesis process in cancer. The present study showed that the expression level of
COPS3
was upregulated in malignant cell lines and
COPS3
overexpression was related with clinical stage, T stage, historical grade. Kaplan-Meier survival curves showed that
COPS3
may function as a prognostic factor for overall survival. CCK-8 and colony formation assays revealed that knockdown of
COPS3
in ACHN and 786-O significantly impacted proliferation in vitro. In addition, flow cytometry showed that inhibition of
COPS3
induced G0/G1 arrest and promoted apoptosis.
COPS3
may promote kidney cancer progression by altering Phospho-AKT(Thr308), Cyclin D1 and
Caspase-3
expression. Collectively, Our findings suggest that
COPS3
may be a new potential target of ccRCC.
...
PMID:Overexpression of COPS3 promotes clear cell renal cell carcinoma progression via regulation of Phospho-AKT(Thr308), Cyclin D1 and Caspase-3. 2947 18
