Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P42345 (mTOR)
 26,049 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
mTOR 1.000
PI3K 0.039
AKT 0.032
S6K1 0.025
4E-BP1 0.022
TSC2 0.012
4EBP1 0.011
AMPK 0.010
TSC1 0.009
ribosomal protein S6 0.009
Raptor 0.007
LC3 0.007
Rheb 0.006
protein kinase B 0.005
raptor 0.004
p70 0.004
PTEN 0.004
phosphatidylinositol 3-kinase 0.004
p70 S6 kinase 0.004
P70S6K 0.004
phosphoinositide 3-kinase 0.003
p62 0.003
Beclin-1 0.003
AMP-activated protein kinase 0.003
eIF4E 0.003
ULK1 0.002
ribosomal protein S6 kinase 1 0.002
ERK 0.002
RICTOR 0.002
tuberin 0.002
MAPK 0.002
ribosomal S6 kinase 0.002
PIK3CA 0.002
REDD1 0.002
Ras homolog enriched in brain 0.002
MEK 0.002
LC3B 0.001
eukaryotic translation initiation factor 4E 0.001
TSC 0.001
phosphatase and tensin homolog 0.001
LKB1 0.001
PDK1 0.001
PKB 0.001
S6K2 0.001
serine/threonine kinase 0.001
ATG5 0.001
P62 0.001
TOR 0.001
muscle protein 0.001
AKT1 0.001
caspase-3 0.001
EGFR 0.001
vascular endothelial growth factor 0.001
RAF 0.001
ERK1 0.001
VEGF 0.001
Bcl-2 0.001
IRS-1 0.001
calcineurin inhibitor 0.001
CDT 0.001
p53 0.001
insulin 0.001
microtubule-associated protein 0.001
FKBP12 0.001
epidermal growth factor receptor 0.001
cyclin D1 0.001
TORC1 0.001
tyrosine kinase 0.001
calcineurin 0.001
atrogin-1 0.000
PI3 0.000
PARP 0.000
TORC2 0.000
SIN1 0.000
Mol 0.000
STAT3 0.000
ATG7 0.000
tensin 0.000
ribosomal S6 protein kinase 0.000
HER2 0.000
more...
Disease
tuberous sclerosis 0.006
cancer 0.002
tumor 0.002
tumor growth 0.001
tumorigenesis 0.001
metastatic renal cell carcinoma 0.001
renal cell carcinoma 0.001
breast cancer 0.000
lymphangioleiomyomatosis 0.000
hepatocellular carcinoma 0.000
tumor progression 0.000
glioblastoma 0.000
renal cancer 0.000
prostate cancer 0.000
Hippel 0.000
non-small cell lung cancer 0.000
carcinogenesis 0.000
glioma 0.000
lung cancer 0.000
polycystic kidney 0.000
MCF 0.000
colorectal cancer 0.000
ovarian cancer 0.000
obesity 0.000
angiomyolipoma 0.000
mantle cell lymphoma 0.000
Hepatocellular carcinoma 0.000
liver cancer 0.000
tumor angiogenesis 0.000
gastric cancer 0.000
PEComa 0.000
pancreatic cancer 0.000
Autosomal dominant polycystic kidney disease 0.000
liver cancer 0.000
diabetes 0.000
squamous cell carcinoma 0.000
colon cancer 0.000
carcinoma 0.000
metastatic breast cancer 0.000
Blocking 0.000
glioblastoma multiforme 0.000
T-cell acute lymphoblastic leukemia 0.000
Cardiac rhabdomyoma 0.000
B-cell lymphoma 0.000
adenocarcinoma 0.000
leukemia 0.000
melanoma 0.000
type 2 diabetes 0.000
metastases 0.000
Glioblastoma 0.000
neuroendocrine tumor 0.000
acute myeloid leukemia 0.000
ATM 0.000
renal cyst 0.000
endometrial cancer 0.000
muscular atrophy 0.000
bladder cancer 0.000
epilepsy 0.000
EMT 0.000
Subependymal giant cell astrocytoma 0.000
Alzheimer's disease 0.000
Idiopathic (IPAH) 0.000
diabetic nephropathy 0.000
tumor initiation 0.000
osteosarcoma 0.000
hyperglycemia 0.000
ABL 0.000
neuroblastoma 0.000
multiple myeloma 0.000
autism 0.000
hamartoma 0.000
Osteosarcoma 0.000
Osteosarcoma 0.000
brain tumor 0.000
Peutz-Jeghers syndrome 0.000
HGF 0.000
BHD 0.000
ischemia 0.000
lymphoma 0.000
AGS 0.000
more...
Symptom
starvation 0.000
seizures 0.000
cachexia 0.000
functional recovery 0.000
Convulsive seizure 0.000
exhaustion 0.000
Scratch 0.000
difficulty with urination 0.000
fatigue 0.000
Peripheral neuropathic pain 0.000
localized abdominal pain 0.000
finger pain 0.000
diarrhea 0.000
pain 0.000
brittle nails 0.000
Neuropathic pain 0.000
memory loss 0.000
collapse 0.000
peri-menopausal 0.000
delayed language development 0.000
anorexia 0.000
Excitable 0.000
elevated mood 0.000
nerve pain 0.000
ataxia 0.000
hypotonia 0.000
splenomegaly 0.000
weakness 0.000
facial droop 0.000
asthenia 0.000
overweight 0.000
Muscle soreness 0.000
neurological disability 0.000
despair 0.000
pachyonychia 0.000
motor symptom 0.000
hypothermia 0.000
pelvic pain 0.000
hyperoxia 0.000
male subfertility 0.000
hepatomegaly 0.000
nausea 0.000
leg edema 0.000
loin pain 0.000
cough 0.000
dyspnea 0.000
bladder pain 0.000
flushing 0.000
acidity 0.000
anesthesia 0.000
incoordination 0.000
arthralgia 0.000
loss of balance 0.000
urinary frequency 0.000
decreased appetite 0.000
Decreased activity 0.000
swollen joints 0.000
polydipsia 0.000
Anoxia 0.000
personality change 0.000
hunger 0.000
acute pain 0.000
respiratory distress 0.000
dry eye 0.000
skin damage 0.000
right upper quadrant pain 0.000
menopausal symptoms 0.000
myalgia 0.000
hoarseness 0.000
bone pain 0.000
intestinal bleeding 0.000
rigors 0.000
exertional dyspnea 0.000
general problem 0.000
blurred vision 0.000
dysesthesia 0.000
hemoptysis 0.000
dry skin 0.000
vomiting 0.000
joint stiffness 0.000
more...
Drug
Everolimus 0.007
NVP 0.002
ROS 0.000
Torisel 0.000
Sorafenib 0.000
3-Methyladenine 0.000
Rapamune 0.000
Benproperine phosphate 0.000
Nexavar 0.000
Tandutinib 0.000
Herceptin 0.000
Sunitinib malate 0.000
Imatinib 0.000
Parkin 0.000
Bevacizumab 0.000
Parkin 0.000
Belatacept 0.000
Lonafarnib 0.000
Cetuximab 0.000
Vandetanib 0.000
N-Formylmethionine 0.000
Gefitinib 0.000
Atractylodes rhizome 0.000
Erlotinib 0.000
Aromasin 0.000
IL-2 0.000
RFP 0.000
Bortezomib 0.000
MAP 0.000
Balanol 0.000
Arsenic trioxide 0.000
Emodin 0.000
Fidarestat 0.000
Fidarestat 0.000
Pemetrexed 0.000
Loxoribine 0.000
Fulvestrant 0.000
Tykerb 0.000
Acadesine 0.000
Pertuzumab 0.000
Emcyt 0.000
DM1 0.000
Longgu 0.000
Aescin 0.000
Emodin 0.000
Dasatinib 0.000
Platonin 0.000
Romidepsin 0.000
Gleevec 0.000
Safingol 0.000
Thioridazine 0.000
Tacrolimus 0.000
Artesunate 0.000
Liraglutide 0.000
GEO 0.000
CoCl2 0.000
CoCl2 0.000
Motesanib 0.000
Metreleptin 0.000
Monit 0.000
Purvalanol 0.000
Epothilone B 0.000
Myricetin 0.000
Provenge 0.000
PDL 0.000
lysine 0.000
Arachidonic Acid 0.000
Zotarolimus 0.000
Glucagon 0.000
Vorinostat 0.000
Norleucine 0.000
Adenosine Monophosphate 0.000
Tipifarnib 0.000
TAK 0.000
Axitinib 0.000
Tarceva 0.000
GHRP 0.000
Compound 19 0.000
Panitumumab 0.000
Asparaginase 0.000
more...
Enzyme
AMP-activated protein kinase 0.011
AMPK 0.010
AMPK 0.005
phosphatidylinositol 3-kinase 0.004
phosphoinositide 3-kinase 0.003
mitogen-activated protein kinase 0.003
ERK 0.002
MEK 0.002
protein kinase 0.001
PDK1 0.001
TOR 0.001
focal adhesion kinase 0.001
caspase-3 0.000
PARP 0.000
calcineurin 0.000
GSK 0.000
eEF2 kinase 0.000
AMP-activated kinase 0.000
proteasome 0.000
phosphatidylinositol-4,5-bisphosphate 3-kinase 0.000
protein phosphatase 2A 0.000
inositol 3-kinase 0.000
STK11 0.000
caspase-9 0.000
protein kinase C 0.000
luciferase 0.000
cdc2 0.000
acetyl-CoA carboxylase 0.000
HK2 0.000
IKK 0.000
phospholipase D 0.000
phosphatidylinositol-3-phosphatase 0.000
farnesyltransferase 0.000
farnesyltransferase 0.000
MAP 0.000
glutaminase 0.000
caspase-8 0.000
superoxide dismutase 0.000
inositol polyphosphate 4-phosphatase 0.000
complex I 0.000
lactate dehydrogenase 0.000
EC 6.1.1.1 0.000
MPP 0.000
branched-chain aminotransferase 0.000
caspase-7 0.000
caspase-7 0.000
ATPase 0.000
asparagine synthetase 0.000
leucyl-tRNA synthetase 0.000
STK2 0.000
phosphatidylinositol 4-kinase 0.000
P-glycoprotein 0.000
cathepsin K 0.000
aspartate aminotransferase 0.000
aldehyde dehydrogenase 0.000
alanine aminotransferase 0.000
aldehyde dehydrogenase 0.000
aldehyde dehydrogenase 0.000
catalase 0.000
GK2 0.000
ecdysone oxidase 0.000
ALDH 0.000
aldehyde dehydrogenase 0.000
IMP dehydrogenase 0.000
NADPH oxidase 0.000
prolyl hydroxylase 0.000
pyruvate kinase 0.000
acylglycerol kinase 0.000
polo-like kinase 1 0.000
NADPH oxidase 0.000
asparaginase 0.000
CaMKII 0.000
arginase 0.000
cathepsin B 0.000
aldehyde dehydrogenase 0.000
cathepsin D 0.000
hexokinase 0.000
AST 0.000
glyceraldehyde-3-phosphate dehydrogenase 0.000
pyruvate dehydrogenase 0.000
more...
Compound
Rapamycin 0.016
Temsirolimus 0.003
MEK 0.002
TSC 0.001
Metformin 0.001
Metformin 0.001
AICAR 0.000
Tuberin 0.000
glucose 0.000
Leucine 0.000
MTT 0.000
threonine 0.000
AICAR 0.000
3-Methyladenine 0.000
oxygen 0.000
leucine 0.000
MDA 0.000
ATP 0.000
Phosphatidylinositol 0.000
serine 0.000
Insulin 0.000
TNF 0.000
tyrosine 0.000
DNA 0.000
Pristimerin 0.000
Pristimerin 0.000
Pristimerin 0.000
Pristimerin 0.000
LY 294002 0.000
glutamine 0.000
AMP 0.000
Wortmannin 0.000
methionine 0.000
FK506 0.000
8-Aminoadenosine 0.000
8-Aminoadenosine 0.000
12-Deoxyphorbol 13-palmitate 0.000
Chelerythrine hydrochloride 0.000
Postin 0.000
Dec 0.000
adenylate 0.000
N-acetylcysteine 0.000
Curcumin 0.000
Resveratrol 0.000
BCR 0.000
Honokiol 0.000
DDP 0.000
Fisetin 0.000
Gymnemic acid I 0.000
DEP 0.000
ABL 0.000
Sinulariolide 0.000
Oxyphenisatin 0.000
Scirpusin A 0.000
C10H13N5O5 0.000
Dioxindole 0.000
Tanshinone 0.000
Celastrol 0.000
DEP 0.000
acridine 0.000
C8H8O3 0.000
6-methylquinoxaline 0.000
XCT 790 0.000
Eburicoic acid 0.000
Auriculasin 0.000
40S 0.000
Cucurbitacin B 0.000
Bufalin 0.000
celastrol 0.000
Matrine 0.000
Matrine 0.000
Matrine 0.000
C19H18O3 0.000
C19H18O3 0.000
C19H18O3 0.000
Tephrosin 0.000
C19H18O3 0.000
Mahanimbine 0.000
C19H18O3 0.000
C19H18O3 0.000
more...