UNIPROT:P42345 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: UNIPROT:P42345 (mTOR)
26,049 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds)

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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein
mTOR	26049
PI3K	4856
AKT	4378
Mol	2655
insulin	1789
Sep	1559
AMPK	1249
MAPK	1215
ERK	1170
S6K1	1123
p53	1099
LC3	1078
4E-BP1	1076
phosphatidylinositol 3-kinase	1035
PTEN	945
protein kinase B	930
caspase-3	912
AMP-activated protein kinase	784
Bcl-2	739
phosphoinositide 3-kinase	730
vascular endothelial growth factor	728
MEK	719
TSC2	707
tyrosine kinase	692
ATP	679
p62	666
cytokine	641
ribosomal protein S6	626
ERK1	607
epidermal growth factor receptor	565
TSC1	561
VEGF	512
p38	501
p70	495
EGFR	491
endoplasmic reticulum	464
Beclin-1	456
4EBP1	448
eIF4E	429
cyclin D1	413
proteasome	407
TNF	402
JNK	384
catenin	377
STAT3	364
PIK3CA	362
HER2	356
PARP	351
ubiquitin	336
p21	334
calcineurin	333
IL-6	333
insulin-like growth factor	331
Raptor	330
serine/threonine kinase	328
ROS	327
phosphatase	320
raptor	303
extracellular signal-regulated kinase	300
estrogen receptor	294
p70 S6 kinase	286
CD4	274
muscle protein	272
IRS-1	270
Rheb	269
collagen	261
BRAF	255
phosphatase and tensin homolog	254
tumor necrosis factor	253
ULK1	245
STAT	244
IGF-1	243
GSK	242
PKB	239
microtubule-associated protein	233
AMP	231
LC3B	229
p27	214
threonine	214
ribosomal protein	213

Disease
cancer	7700
tumor	5265
breast cancer	1380
tumor growth	1317
tumorigenesis	1078
tuberous sclerosis	954
diabetes	777
hepatocellular carcinoma	735
renal cell carcinoma	636
obesity	615
carcinoma	554
lung cancer	532
tumor progression	531
carcinogenesis	515
prostate cancer	506
metastases	437
leukemia	417
colorectal cancer	411
Alzheimer's disease	384
melanoma	358
adenocarcinoma	357
glioma	350
glioblastoma	336
type 2 diabetes	326
non-small cell lung cancer	310
MCF	308
epilepsy	308
squamous cell carcinoma	306
gastric cancer	304
ovarian cancer	297
ischemia	291
lymphoma	255
colon cancer	246
acute myeloid leukemia	236
Parkinson's disease	229
metastatic renal cell carcinoma	225
pancreatic cancer	225
hypertension	212
multiple myeloma	201
liver cancer	199
depression	199
hyperglycemia	191
autism	185
neuroblastoma	183
B-cell lymphoma	176
atherosclerosis	163
liver cancer	159
bladder cancer	156
stroke	155
renal disease	155
renal cancer	150
heart failure	146
osteosarcoma	144
ATM	143
sarcoma	142
Hippel	138
polycystic kidney	135
cognitive impairment	135
cervical cancer	134
Blocking	133
glioblastoma multiforme	133
endometrial cancer	132
cardiovascular disease	132
Hepatocellular carcinoma	131
proteinuria	129
acute lymphoblastic leukemia	126
tumor angiogenesis	125
metastatic breast cancer	124
diabetic nephropathy	118
virus infection	117
lymphangioleiomyomatosis	114
cerebral ischemia	112
lung carcinoma	110
fatty liver	110
brain tumor	109
muscular atrophy	109
chronic myeloid leukemia	109
mantle cell lymphoma	103
Hodgkin's disease	101
skin cancer	100

Symptom
starvation	419
seizures	253
pain	141
fatigue	83
functional recovery	68
diarrhea	66
exhaustion	52
cachexia	52
collapse	38
weakness	34
anesthesia	31
overweight	27
anorexia	24
ataxia	23
nausea	17
splenomegaly	17
hypothermia	16
dyspnea	16
cough	15
memory loss	13
hypotonia	13
acidity	11
respiratory distress	10
vomiting	10
headache	9
hepatomegaly	8
Neuropathic pain	8
asthenia	8
hyperoxia	8
pelvic pain	7
arthralgia	7
flushing	7
abdominal pain	7
analgesia	7
Scratch	7
myalgia	5
hunger	5
despair	5
discomfort	5
erythema	5
discomfort	5
constipation	4
neurological disability	4
angina	4
hemoptysis	4
tremor	4
back pain	4
acute pain	4
hoarseness	3
polydipsia	3
low back pain	3
exertional dyspnea	3
bone pain	3
nausea and vomiting	3
hepatosplenomegaly	3
distraction	3
incoordination	3
dry eye	3
thinning	3
acute stress	3
shortness of breath	3
peri-menopausal	2
menopausal symptoms	2
urinary frequency	2
decreased appetite	2
leg edema	2
motor symptom	2
cancer pain	2
polyuria	2
Ill	2
blurred vision	2
dystonia	2
skin damage	2
rigors	1
cerebellar ataxia	1
bladder pain	1
general problem	1
agitation	1
apathy	1
Peripheral neuropathic pain	1

Enzyme
mitogen-activated protein kinase	2647
ERK	2431
AMP-activated protein kinase	1962
protein kinase	1578
AMPK	1266
AMPK	1249
phosphatidylinositol 3-kinase	1035
MEK	880
focal adhesion kinase	788
phosphoinositide 3-kinase	730
caspase-3	641
calcineurin	433
proteasome	408
PARP	394
protein kinase C	315
luciferase	264
GSK	260
PDK1	210
superoxide dismutase	169
TOR	161
ATPase	136
caspase-9	123
cdc2	115
lactate dehydrogenase	107
catalase	105
protein phosphatase 2A	84
IKK	75
alanine aminotransferase	73
aspartate aminotransferase	68
MAP	64
acetyl-CoA carboxylase	64
phospholipase D	62
complex I	59
ACS	59
caspase-8	57
RNA polymerase	56
P-glycoprotein	56
AMP-activated kinase	52
alkaline phosphatase	51
NADPH oxidase	42
NADPH oxidase	42
peroxidase	42
eEF2 kinase	41
renin	41
glutathione peroxidase	39
phospholipase C	36
APC	35
glutathione S-transferase	33
STK11	30
aldehyde dehydrogenase	30
glutaminase	30
aldehyde dehydrogenase	30
reverse transcriptase	30
aldehyde dehydrogenase	29
aldehyde dehydrogenase	29
pyruvate kinase	29
NO synthase	29
aldehyde dehydrogenase	29
thrombin	29
farnesyltransferase	29
glyceraldehyde-3-phosphate dehydrogenase	28
NOS	27
AST	27
farnesyltransferase	27
creatine kinase	27
phosphatidylinositol-4,5-bisphosphate 3-kinase	26
hexokinase	26
topoisomerase	25
HK2	25
MPP	25
phosphodiesterase	25
topoisomerase	25
collagenase	25
cathepsin B	24
pyruvate dehydrogenase	24
CaMKII	24
cathepsin D	23
arginase	23
lipase	23
DNA methyltransferase	22