Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P42345 (mTOR)
 26,049 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
mTOR 26049
PI3K 4856
AKT 4378
Mol 2655
insulin 1789
Sep 1559
AMPK 1249
MAPK 1215
ERK 1170
S6K1 1123
p53 1099
LC3 1078
4E-BP1 1076
phosphatidylinositol 3-kinase 1035
PTEN 945
protein kinase B 930
caspase-3 912
AMP-activated protein kinase 784
Bcl-2 739
phosphoinositide 3-kinase 730
vascular endothelial growth factor 728
MEK 719
TSC2 707
tyrosine kinase 692
ATP 679
p62 666
cytokine 641
ribosomal protein S6 626
ERK1 607
epidermal growth factor receptor 565
TSC1 561
VEGF 512
p38 501
p70 495
EGFR 491
endoplasmic reticulum 464
Beclin-1 456
4EBP1 448
eIF4E 429
cyclin D1 413
proteasome 407
TNF 402
JNK 384
catenin 377
STAT3 364
PIK3CA 362
HER2 356
PARP 351
ubiquitin 336
p21 334
IL-6 333
calcineurin 333
insulin-like growth factor 331
Raptor 330
serine/threonine kinase 328
ROS 327
phosphatase 320
raptor 303
extracellular signal-regulated kinase 300
estrogen receptor 294
p70 S6 kinase 286
CD4 274
muscle protein 272
IRS-1 270
Rheb 269
collagen 261
BRAF 255
phosphatase and tensin homolog 254
tumor necrosis factor 253
ULK1 245
STAT 244
IGF-1 243
GSK 242
PKB 239
microtubule-associated protein 233
AMP 231
LC3B 229
threonine 214
p27 214
ribosomal protein 213
KRAS 208
IFN 204
interferon 201
ribosomal S6 kinase 200
c-Myc 195
PI3 191
CDK4 189
histone 188
LKB1 187
VEGFR2 184
receptor tyrosine kinase 183
Mcl-1 182
caspase-9 181
CD8 180
RAF 179
tuberin 178
histone deacetylase 177
leptin 177
lipopolysaccharide 176
calcineurin inhibitor 176
AKT1 173
annexin V 171
rhabdomyosarcoma 163
P70S6K 163
brain-derived neurotrophic factor 161
TOR 161
FRAP 160
MEK1 157
E-cadherin 156
PKC 155
PDK1 154
somatostatin 153
ATG5 152
insulin receptor 150
GTPase 150
MET 143
survivin 142
epidermal growth factor 142
PDB 136
cytochrome c 136
axonal 135
IL-10 135
hormone receptor 134
proline-rich 133
LPS 132
eukaryotic translation initiation factor 4E 131
TSC 130
gut 127
p65 126
Nrf2 126
lymphoid 125
cyclin 125
osteosarcoma 124
CCK 124
proliferating cell nuclear antigen 124
PC-3 123
serine/threonine protein kinase 123
mitogen-activated protein 123
ATPase 122
ATM 118
glucose transporter 117
IGF-I 117
aromatase 117
androgen receptor 116
SIRT1 116
REDD1 116
TLR4 115
FKBP12 113
c-Jun 113
MYC 113
matrix metalloproteinase 112
UTR 112
IL-8 112
EGF 111
tensin 111
HIF-1 111
MMP-9 110
superoxide dismutase 109
phosphorylating 108
peroxisome proliferator-activated receptor 108
more...
Disease
cancer 7700
tumor 5265
breast cancer 1380
tumor growth 1317
tumorigenesis 1078
tuberous sclerosis 954
diabetes 777
hepatocellular carcinoma 735
renal cell carcinoma 636
obesity 615
carcinoma 554
lung cancer 532
tumor progression 531
carcinogenesis 515
prostate cancer 506
metastases 437
leukemia 417
colorectal cancer 411
Alzheimer's disease 384
melanoma 358
adenocarcinoma 357
glioma 350
glioblastoma 336
type 2 diabetes 326
non-small cell lung cancer 310
epilepsy 308
MCF 308
squamous cell carcinoma 306
gastric cancer 304
ovarian cancer 297
ischemia 291
lymphoma 255
colon cancer 246
acute myeloid leukemia 236
Parkinson's disease 229
pancreatic cancer 225
metastatic renal cell carcinoma 225
hypertension 212
multiple myeloma 201
depression 199
liver cancer 199
hyperglycemia 191
autism 185
neuroblastoma 183
B-cell lymphoma 176
atherosclerosis 163
liver cancer 159
bladder cancer 156
renal disease 155
stroke 155
renal cancer 150
heart failure 146
osteosarcoma 144
ATM 143
sarcoma 142
Hippel 138
cognitive impairment 135
polycystic kidney 135
cervical cancer 134
glioblastoma multiforme 133
Blocking 133
endometrial cancer 132
cardiovascular disease 132
Hepatocellular carcinoma 131
proteinuria 129
acute lymphoblastic leukemia 126
tumor angiogenesis 125
metastatic breast cancer 124
diabetic nephropathy 118
virus infection 117
lymphangioleiomyomatosis 114
cerebral ischemia 112
lung carcinoma 110
fatty liver 110
muscular atrophy 109
chronic myeloid leukemia 109
brain tumor 109
mantle cell lymphoma 103
Hodgkin's disease 101
skin cancer 100
dysplasia 99
GSH 98
metabolic syndrome 98
retinoblastoma 94
sepsis 92
sepsis 90
hyperinsulinemia 87
anemia 86
HIV 86
aggressiveness 86
Leukemia 82
pneumonia 82
genetic disorder 80
colitis 80
epithelial ovarian cancer 79
thyroid cancer 79
hyperlipidemia 79
rheumatoid arthritis 78
primary tumor 77
myocardial ischemia 77
cytomegalovirus 77
Huntington's disease 75
stomatitis 74
hematologic malignancies 74
ABL 74
myocardial infarction 74
angiomyolipoma 73
Glioblastoma 72
T-cell acute lymphoblastic leukemia 69
tumor initiation 67
DDP 66
systemic lupus erythematosus 65
Kaposi's sarcoma 65
osteoporosis 65
renal failure 65
rhabdomyosarcoma 64
EMT 64
multiple sclerosis 63
autoimmune disease 63
astrocytoma 63
glucose intolerance 63
hamartoma 62
neuroendocrine tumor 62
dementia 62
osteoarthritis 62
solid tumor 61
plaque 61
thrombocytopenia 61
cold 60
infectious diseases 59
schizophrenia 59
malnutrition 59
SCID 58
infertility 57
lung disease 56
cirrhosis 56
tuberculosis 55
asthma 55
esophageal cancer 55
rash 52
NOD 52
major depressive disorder 52
Epstein 51
hepatitis C 51
mental retardation 50
mental retardation 50
neurofibromatosis type 1 50
Melanoma 50
immunodeficiency 49
leukemogenesis 49
esophageal cancer 49
HGF 49
renal cyst 48
Mycobacterium 47
Autosomal dominant polycystic kidney disease 46
Osteosarcoma 46
Osteosarcoma 46
dyslipidemia 46
carcinoid 45
arthritis 45
more...
Symptom
starvation 419
seizures 253
pain 141
fatigue 83
functional recovery 68
diarrhea 66
exhaustion 52
cachexia 52
collapse 38
weakness 34
anesthesia 31
overweight 27
anorexia 24
ataxia 23
splenomegaly 17
nausea 17
dyspnea 16
hypothermia 16
cough 15
memory loss 13
hypotonia 13
acidity 11
respiratory distress 10
vomiting 10
headache 9
hepatomegaly 8
Neuropathic pain 8
asthenia 8
hyperoxia 8
pelvic pain 7
flushing 7
arthralgia 7
analgesia 7
Scratch 7
abdominal pain 7
despair 5
myalgia 5
discomfort 5
discomfort 5
erythema 5
hunger 5
constipation 4
neurological disability 4
angina 4
tremor 4
hemoptysis 4
back pain 4
acute pain 4
polydipsia 3
acute stress 3
exertional dyspnea 3
nausea and vomiting 3
distraction 3
incoordination 3
hepatosplenomegaly 3
dry eye 3
hoarseness 3
thinning 3
shortness of breath 3
bone pain 3
low back pain 3
peri-menopausal 2
motor symptom 2
polyuria 2
dystonia 2
Ill 2
blurred vision 2
cancer pain 2
decreased appetite 2
leg edema 2
urinary frequency 2
skin damage 2
menopausal symptoms 2
rigors 1
cerebellar ataxia 1
bladder pain 1
general problem 1
agitation 1
apathy 1
Peripheral neuropathic pain 1
Decreased activity 1
localized abdominal pain 1
cyanosis 1
tonic-clonic seizure 1
dizziness 1
Excitable 1
elevated mood 1
male subfertility 1
HSA 1
intestinal bleeding 1
dysarthria 1
loss of balance 1
bradykinesia 1
right upper quadrant pain 1
Anoxia 1
facial droop 1
tinnitus 1
Muscle soreness 1
abnormal gait 1
spasticity 1
night sweats 1
shoulder pain 1
flank pain 1
loin pain 1
insomnia 1
nerve pain 1
sore throat 1
pachyonychia 1
joint stiffness 1
difficulty with urination 1
hip pain 1
delayed language development 1
hypercapnia 1
Convulsive seizure 1
personality change 1
finger pain 1
vertigo 1
hot flushes 1
snoring 1
dry skin 1
brittle nails 1
leg pain 1
numbness 1
dysesthesia 1
spasm 1
chills 1
swollen joints 1
Drug
Everolimus 350
ROS 327
NVP 199
Dermatol 114
IL-2 103
lysine 93
Sorafenib 83
Monit 74
MAP 73
Cardiovasc 52
Imatinib 43
Herceptin 43
Parkin 35
Parkin 35
Bevacizumab 34
CSF 30
3-Methyladenine 26
Gefitinib 25
NADH 24
Ethanol 23
Cetuximab 23
caffeine 22
Bortezomib 22
Glucagon 22
RFP 20
ENT 20
DM1 19
Arsenic trioxide 19
Tacrolimus 17
Erlotinib 17
Dial 17
lactose 17
ABC 16
Gleevec 16
GEO 16
IFN-gamma 15
Rituximab 14
CoCl2 14
CoCl2 14
EE2 13
vitamin E 12
Adriamycin 11
Simvastatin 11
citric acid 11
Dasatinib 11
Emodin 11
Emodin 11
TAK 10
Rapamune 10
Nexavar 10
Sunitinib malate 10
Pemetrexed 10
Angiotensin II 10
PDL 9
Taxol 9
TTC 9
ETS 9
Nephron 9
Fulvestrant 9
MRC 9
p75 9
Itraconazole 9
ADR 8
G-CSF 8
Belatacept 8
Liraglutide 8
Vandetanib 8
CTX 8
TAC 8
uPA 8
ascorbate 8
niacin 8
Glycyrrhiza 7
Torisel 7
ALA 7
GHRP 7
Rosiglitazone 7
Indomethacin 7
Artesunate 7
Activin 7
CAM 7
Retinoic acid 7
ADM 7
Heme 6
-deoxyadenosine 6
Mutagen 6
Propofol 6
Spectrum 6
Vorinostat 6
Myricetin 6
CTX 6
CTX 6
Oxaliplatin 6
Portal 6
Thioridazine 6
Kenyan 6
Nephron 5
Spectrum 5
PTH 5
Fraction 5
ICI 5
Lovastatin 5
Glutathione 5
Docetaxel 5
Pertuzumab 5
PTC 5
Donepezil 5
Gelatin 5
Leaf 4
Tarceva 4
Estrogens 4
ZnO 4
Campath 4
Alanine 4
Triclosan 4
Bupivacaine 4
ROC 4
Zoledronic acid 4
Lonafarnib 4
Fluorescein 4
Nitric Oxide 4
PFT 4
DEX 4
Campath 4
Asn 4
Azithromycin 4
Forskolin 4
Epigallocatechin 4
Vitamin E 4
MDS 4
NAG 4
Albumin 4
Romidepsin 4
TAT 4
Ouabain 4
Rutin 4
Asparaginase 4
Alliance 4
Methylene blue 4
Tykerb 3
Ginger 3
Zoledronic acid 3
Pilocarpine 3
Mycophenolic acid 3
Bifidobacterium 3
Ranitidine 3
BH4 3
Growth hormone 3
Silica 3
Gel 3
Orlistat 3
Paraffin 3
Panitumumab 3
CTC 3
Aloe 3
Asthma 3
Doxycycline 3
Growth hormone 3
Vitamin A 3
THF 3
more...
Enzyme
mitogen-activated protein kinase 2647
ERK 2431
AMP-activated protein kinase 1962
protein kinase 1578
AMPK 1266
AMPK 1249
phosphatidylinositol 3-kinase 1035
MEK 880
focal adhesion kinase 788
phosphoinositide 3-kinase 730
caspase-3 641
calcineurin 433
proteasome 408
PARP 394
protein kinase C 315
luciferase 264
GSK 260
PDK1 210
superoxide dismutase 169
TOR 161
ATPase 136
caspase-9 123
cdc2 115
lactate dehydrogenase 107
catalase 105
protein phosphatase 2A 84
IKK 75
alanine aminotransferase 73
aspartate aminotransferase 68
acetyl-CoA carboxylase 64
MAP 64
phospholipase D 62
ACS 59
complex I 59
caspase-8 57
P-glycoprotein 56
RNA polymerase 56
AMP-activated kinase 52
alkaline phosphatase 51
peroxidase 42
NADPH oxidase 42
NADPH oxidase 42
eEF2 kinase 41
renin 41
glutathione peroxidase 39
phospholipase C 36
APC 35
glutathione S-transferase 33
glutaminase 30
STK11 30
reverse transcriptase 30
aldehyde dehydrogenase 30
aldehyde dehydrogenase 30
farnesyltransferase 29
aldehyde dehydrogenase 29
thrombin 29
aldehyde dehydrogenase 29
pyruvate kinase 29
NO synthase 29
aldehyde dehydrogenase 29
glyceraldehyde-3-phosphate dehydrogenase 28
NOS 27
farnesyltransferase 27
creatine kinase 27
AST 27
phosphatidylinositol-4,5-bisphosphate 3-kinase 26
hexokinase 26
topoisomerase 25
phosphodiesterase 25
collagenase 25
topoisomerase 25
HK2 25
MPP 25
pyruvate dehydrogenase 24
CaMKII 24
cathepsin B 24
lipase 23
arginase 23
cathepsin D 23
ATP synthase 22
caspase-1 22
DNA methyltransferase 22
inositol 3-kinase 21
CPT 21
pyruvate dehydrogenase 20
cathepsin K 20
asparaginase 20
phosphoenolpyruvate carboxykinase 20
pyruvate dehydrogenase 20
succinate dehydrogenase 19
urokinase-type plasminogen activator 19
tyrosine hydroxylase 19
phosphoenolpyruvate carboxykinase 18
ornithine decarboxylase 18
phosphoenolpyruvate carboxykinase 18
ACE 18
granzyme B 18
prolyl hydroxylase 17
CYP3A4 17
caspase-7 16
MMP 16
citrate synthase 16
NQO1 16
caspase-7 16
polo-like kinase 1 15
demethylase 15
glucose-6-phosphatase 15
glutamate dehydrogenase 15
glutamate dehydrogenase 15
glutamate dehydrogenase 15
phosphofructokinase 14
PKG 14
glyceraldehyde-3-phosphate dehydrogenase 13
phosphatidylinositol 4-kinase 12
glucose-6-phosphate dehydrogenase 12
CPT 12
CPT 12
phospholipase A2 12
glutamine synthetase 12
trypsin 12
acid phosphatase 12
acetylcholinesterase 12
IMP dehydrogenase 12
ALDH 12
asparagine synthetase 11
RNase 11
triphosphatase 11
RNase 11
matrix metalloproteinase 2 10
lipoxygenase 10
matrix metalloproteinase 9 10
lipoprotein lipase 10
phosphorylase 10
diacylglycerol kinase 10
hormone-sensitive lipase 10
enolase 10
isocitrate dehydrogenase 9
MMP-3 9
glyceraldehyde-3-phosphate dehydrogenase 9
isocitrate dehydrogenase 9
HSD 9
glyceraldehyde-3-phosphate dehydrogenase 9
cytochrome oxidase 9
histidine kinase 9
thymidylate synthase 9
glyceraldehyde-3-phosphate dehydrogenase 9
carbonic anhydrase 8
m-calpain 8
branched-chain aminotransferase 8
peroxiredoxin 8
CD10 8
tissue plasminogen activator 8
leucyl-tRNA synthetase 8
histone demethylase 8
CD13 8
transcriptase 8
MEKK1 8
CAD 8
CAD 8
CAD 8
more...
Compound
Dec 1663
glucose 1567
DNA 1420
oxygen 1247
Rapamycin 1170
Clin 891
MEK 717
ATP 679
threonine 515
leucine 500
tyrosine 493
MTT 456
serine 444
TNF 402
calcium 365
MDA 305
methionine 298
Insulin 285
AMP 282
water 279
Metformin 239
Metformin 239
glutamine 230
phosphate 223
glutamate 187
sodium 186
arginine 167
cAMP 161
cysteine 159
nitric oxide 154
hydrogen 135
lysine 133
TSC 131
Leucine 124
nitrogen 119
urea 117
N-acetylcysteine 115
Temsirolimus 106
alanine 105
acetate 103
GSH 101
GSH 101
iodine 99
creatinine 97
bromide 96
ethanol 94
Phosphatidylinositol 93
GTP 91
AICAR 90
FK506 89
adenylate 88
DDP 87
Curcumin 87
NAD 85
AICAR 84
BCR 83
Phe 79
galactose 78
ABL 74
Ile 71
Resveratrol 71
acridine 70
MAP 68
Cardiol 67
iron 66
sulfate 65
retinoic acid 65
ADP 65
pyrimidine 62
pyrimidine 61
NAD 61
THP 60
THP 60
ACS 59
ACS 59
zinc 59
AMPA 57
ADP 57
ADP 57
dUTP 53
boron 53
TNM 51
proline 50
ADP-ribose 49
isoleucine 49
H2O2 48
isoleucine 47
GABA 47
GABA 47
valine 47
Adriamycin 47
nicotinamide 46
His 45
Wortmannin 45
2-oxoglutarate 44
ADR 44
salt 43
pentose 43
pentose 43
pentose 43
pentose 43
NMDA 43
cadmium 43
palmitic acid 43
40S 42
vitamin D 42
tryptophan 40
Ang II 38
TCA 38
potassium 37
NH2 37
selenium 36
Serine 36
5-HT 36
tryptophan 35
PEG 35
ASA 35
Panam 34
palmitic acid 33
Pac 32
Melatonin 32
tryptophan 32
tryptophan 32
DMSO 32
Asp 31
PEG 31
MTS 30
PMA 30
5-FU 30
Neuronal 29
H2S 29
aldosterone 29
Vimentin 29
Glutamine 29
L-leucine 28
NADPH 28
NADPH 28
Ketamine 27
DEP 26
Tamoxifen 26
Tamoxifen 26
DEP 26
Quercetin 26
3-Methyladenine 26
asparagine 25
MPP 25
Gly 25
CAT 25
CAT 25
Thyroid 25
MPP 25
STZ 25
Guo 25
CAT 25
CoA 25
TOF 24
NADH 24
GAP 24
Tuberin 24
LY 294002 23
more...