Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UNIPROT:P42345 (
mTOR
)
26,049
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
mammalian target of rapamycin
(
mTOR
) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism.
mTOR
forms two distinct multiprotein complexes known as
mTOR
complex 1 (mTORC1) and
mTOR
complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively.
mTOR
controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1),
F-box/WD repeat-containing protein 8
(Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of
mTOR
regulation in insulin signaling in the context of whole body metabolism.
...
PMID:The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling. 2907 2
