Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42345 (
mTOR
)
26,049
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
L-Methionine sulfoximine
(MSO) and DL-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the
mTOR
substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where
mTOR
activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of
mTOR
activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are
mTOR
activators.
...
PMID:The non-proteinogenic amino acids L-methionine sulfoximine and DL-phosphinothricin activate mTOR. 2176 96
