Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P42345 (
mTOR
)
26,049
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Methylcobalamin
(
MeCbl
), a vitamin B12 analog, promotes neurite outgrowth by activating Akt in neurons. However, Akt is involved in many cellular functions, and the downstream signal of Akt that promotes neurite outgrowth in neurons in the presence of
MeCbl
remains obscure.
Mammalian target of rapamycin
(
mTOR
) is a serine/threonine protein kinase that regulates multiple cellular functions including neurite outgrowth.
mTOR
is regarded as important for the regeneration of injured nerves. In this study, we examined the relationship between
MeCbl
and
mTOR
activity and found that
MeCbl
increases
mTOR
activity via the activation of Akt and promotes neurite outgrowth in cerebellar granule neurons via the activation of
mTOR
.
...
PMID:Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin. 2145 38
