Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P41181 (collecting duct)
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Human Gene/Protein
VIT32 12.6
VIP32 12.6
FHAD1 12.6
PCD9 12.6
Rh type B glycoprotein 12.6
COMMD2 12.6
xGPAT1 12.6
synaptotagmin VIII 12.6
collecting duct 12.6
AQP2 protein 12.1
V-ATPase B1 subunit 11.6
chloride channel CLC-5 11.6
RCCD1 11.6
Histone H4 gene 11.6
Aquaporin-2 mutant 11.6
KIAA1185 11.6
aquaporin 2 11.5
MIWC 11.4
cGMP-gated cation channel protein 11.3
dyf-13 11.0
Transmembrane protein 174 11.0
glycerophosphodiester phosphodiesterase domain containing 5 11.0
aquaporin 6 11.0
AQP2 11.0
Aquaporin adipose 10.9
UT-A2 10.8
RNF183 10.7
ENaCalpha 10.6
kinesin family member 3B 10.6
N4WBP5A 10.6
ENaCgamma 10.6
TMEM51 10.6
GPR80 10.5
AE2 anion exchanger 10.5
aquaporin-3 10.4
MCD4 10.4
ROMK 10.4
ClC-K2 10.4
AKAP18 10.4
CHIP28 10.3
VPP1 10.3
IBA2 10.3
COMMD9 10.3
phosphodiesterase 4C 10.3
PRKWNK4 10.3
pendrin 10.2
UT2 10.1
Pendrin 10.1
TTC26 10.0
MAPKBP1 10.0
ENaCbeta 10.0
B/K protein 10.0
AVPR2 10.0
Na,K-ATPase gamma subunit 10.0
Receptor activity-modifying protein 3 10.0
P2Y2-like 10.0
DAPL1 10.0
collagen type IV alpha 2 10.0
MOX1 10.0
38KD 10.0
NHE4 9.9
Ksp-cadherin 9.9
ATP6B1 9.9
NBC3 9.9
ENaC 9.8
SLC4A5 9.8
BSC1 9.8
bumetanide-sensitive Na-K-2Cl cotransporter 9.8
CNKSR3 9.8
EMI domain-containing protein 2 9.8
arginine vasopressin V2 receptor 9.8
COMMD3 9.8
ERAP140 9.8
aquaporin 9.7
CHIF 9.7
AQP3 9.7
ATP6V0A4 9.7
AE4 9.7
Tonicity-responsive enhancer binding protein 9.7
HUT11 9.7
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Disease
Acquired nephrogenic diabetes insipidus 11.6
Renal coccidiosis 11.0
Congenital nephrogenic diabetes insipidus 10.8
Bellini duct carcinoma 10.6
Familial central diabetes insipidus 10.6
nephrogenic diabetes insipidus 10.3
NSIAD 10.3
Chronic hyperkalemia 10.3
Metanephric adenofibroma 10.0
FH II 10.0
Chromophobe cell renal carcinoma 9.4
Distal renal tubular acidosis 9.4
Liddle's syndrome 9.2
antidiuresis 9.2
Colonic pseudo-obstruction 8.8
Autosomal recessive polycystic kidney disease 8.7
NPHP2 8.6
Polyomavirus-associated nephropathy 8.6
PHA2 8.6
Gordon's syndrome 8.4
Cystic kidney disease 8.3
Renal oncocytoma 8.2
Renal tubular dysfunction 8.0
hyperosmolality 7.9
Dent's disease 7.9
NDI 7.9
Ask-Upmark kidney 7.8
sponge kidney 7.8
Mesoblastic nephroma 7.7
Hereditary Leiomyomatosis and Renal Cell Cancer 7.7
renal tubular acidosis 7.7
pelvic neoplasm 7.6
polycystic kidney 7.5
gouty nephropathy 7.5
Pseudohypoaldosteronism 7.5
renal papillary necrosis 7.5
MKS3 7.5
NPHP3 7.4
BSND 7.3
Bartter's syndrome 7.3
metabolic alkalosis 7.2
pancreatic gastrinoma 7.2
Autosomal dominant polycystic kidney disease 7.2
NPHP1 7.1
renal cyst 7.1
hypo-osmolality 7.1
BK virus nephropathy 7.0
Luminal 7.0
synchronous neoplasms 7.0
Psammoma 6.9
Acute pyelonephritis 6.9
Oncocytoma 6.8
Oncocytoma 6.8
diabetes insipidus 6.8
Oncocytoma 6.8
Gitelman syndrome 6.7
uricosuria 6.7
hyporeninemic hypoaldosteronism 6.7
Benign neoplasms 6.7
Ureter 6.7
Benign neoplasms 6.7
Ureter 6.7
Metanephric adenoma 6.5
Familial hypocalciuric hypercalcemia 6.5
alkalosis 6.5
Renal interstitial fibrosis 6.5
Ovarian metastasis 6.5
potassium deficiency 6.4
BHD 6.4
Ureteral obstruction 6.3
urinary tract obstruction 6.3
Central diabetes insipidus 6.3
hypernatremia 6.2
hypercalciuria 6.2
Heck's disease 6.2
nephrocalcinosis 6.2
kidney tumor 6.1
Azotemia 6.1
Tubulointerstitial nephritis 6.1
BK virus infection 6.1
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Symptom
excessive urination 9.6
polyuria 8.1
Macula 7.3
polydipsia 6.8
male puberty 6.1
Cushingoid 4.8
Cushingoid 4.8
rundown 4.6
abdominal fullness 3.9
oliguria 3.7
Decreased activity 3.5
ketonuria 3.5
persistent cough 3.3
flank pain 3.1
chest tightness 3.0
renal colic 2.9
hypercapnia 2.2
bitter taste 2.1
enuresis 1.9
hypocapnia 1.9
back pain 1.3
functional recovery 1.2
lethargy 1.1
flushing 0.9
low back pain 0.9
constipation 0.8
acidity 0.7
anorexia 0.4
acute stress 0.4
dizziness 0.3
numbness 0.2
shortness of breath 0.2
hunger 0.1
collapse 0.1
tinnitus -0.1
weakness -0.3
vomiting -0.4
tremor -0.6
syncope -0.6
splenomegaly -0.7
cough -1.0
fatigue -1.1
exhaustion -1.2
dyspnea -1.2
diarrhea -1.2
ataxia -1.4
respiratory distress -1.7
seizures -1.7
starvation -2.0
anesthesia -2.2
abdominal pain -2.3
headache -3.2
pain -4.4
Drug
DOCP 9.6
Demeclocycline 8.2
Micardis 8.1
Imidafenacin 8.1
Sulprostone 7.9
RPH 7.8
Camostat mesilate 7.8
Tolvaptan 7.6
Amiloride 7.4
Amiloride 7.2
Piretanide 6.9
Parecoxib 6.8
Butaprost 6.6
Nafamostat mesilate 6.6
Chlorothiazide 6.6
DDAVP 6.3
Aliskiren 6.1
DDAVP 6.1
Fenoldopam 6.0
Torasemide 5.9
Bumetanide 5.9
Bosentan 5.9
Bosentan 5.9
Plavix 5.6
Roflumilast 5.6
Roflumilast 5.6
Hydrochlorothiazide 5.5
ETA 5.4
Ouabain 5.3
KGF 5.3
Atipamezole 5.2
Felodipine 5.1
Forskolin 5.0
Carbenoxolone 5.0
Diamminedichloroplatinum 4.9
Olmesartan 4.9
NH3 4.8
Phosphoramidon 4.8
Angiotensin II 4.8
Valsartan 4.7
Nephron 4.6
AmBisome 4.6
Iloprost 4.5
Pitressin 4.5
KCL 4.5
Helium 4.3
Vena 4.3
Vena 4.3
Nephron 4.2
AC2 4.2
Ringer's solution 4.1
MDM 3.9
Rolipram 3.8
Hyaluronidase 3.8
Viagra 3.7
Sodium nitroprusside 3.7
Hyaluronidase 3.6
EHDP 3.6
Troglitazone 3.5
NAG 3.5
Clopidogrel 3.5
Viagra 3.4
Urokinase 3.3
R1881 3.3
Adenosine deaminase 3.2
Everolimus 3.1
Indomethacin 3.1
Secretin 3.1
Glucagon 3.0
Erlotinib 3.0
ETS 2.8
Adenosine triphosphate 2.8
Aprotinin 2.7
Monensin 2.7
Albumin 2.7
PFA 2.6
Diphenhydramine 2.6
CTC 2.5
ICI 2.5
Estrogens 2.4
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Enzyme
prostasin 9.0
site-1 protease 8.4
H,K-ATPase 8.3
glycerophosphocholine phosphodiesterase 8.0
RPH 7.9
site-1 protease 7.4
11beta-hydroxysteroid dehydrogenase 6.6
ubiquitin-protein ligase 6.3
gluconate dehydrogenase 6.1
matrix metalloproteinase 14 6.1
carbonic anhydrase 5.9
ketohexokinase 5.9
ADH 5.9
DAP II 5.8
alpha-methylacyl-CoA racemase 5.8
ATPase 5.8
AMP-activated kinase 5.7
N-acetylgalactosaminidase 5.5
cGMP phosphodiesterase 5.5
fumarase 5.4
PKG 5.4
oxaloacetate decarboxylase 5.2
sorbitol dehydrogenase 5.1
DCF 5.1
tissue kallikrein 5.1
aldose reductase 5.0
PIP kinase 4.9
phosphocholine cytidylyltransferase 4.8
aminopeptidase B 4.8
proton-translocating ATPase 4.8
inositol 3-kinase 4.7
oxytocinase 4.7
sphingomyelin synthase 4.7
endo-N 4.7
ornithine aminotransferase 4.7
guanylate cyclase 4.7
estrogen sulfotransferase 4.7
renin 4.6
kallikrein 4.6
ADH3 4.6
HK2 4.5
citrate lyase 4.5
biliverdin reductase 4.5
1-hydroxylase 4.4
caspase-7 4.4
LTA4 hydrolase 4.3
caspase-7 4.3
dimethylarginine dimethylaminohydrolase 4.3
uridine phosphorylase 4.3
15-hydroxyprostaglandin dehydrogenase 4.3
adenylate cyclase 4.2
HSD 4.1
CPT 4.1
protein kinase C 4.1
nucleotide pyrophosphatase 4.0
protein kinase 4.0
prostacyclin synthase 4.0
CPT 4.0
cathepsin C 4.0
furin 3.9
3'-exonuclease 3.9
PST 3.9
phospholipase C 3.9
aminopeptidase A 3.9
phosphodiesterase 3.8
NO synthase 3.8
alcohol dehydrogenase 3.8
purine nucleoside phosphorylase 3.7
DMT 3.7
CPT 3.6
angiotensin-converting enzyme 2 3.6
apyrase 3.6
neuropathy target esterase 3.5
aromatic L-amino acid decarboxylase 3.5
myosin light chain kinase 3.5
ADPase 3.5
estrogen sulfotransferase 3.5
isopeptidase 3.4
pyruvate kinase 3.4
cathepsin D 3.4
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Compound
2-Bromoethylamine hydrobromide 11.0
2-Bromoethylamine hydrobromide 11.0
8-Aminoguanine 10.6
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
Vasopressin 8.7
2-sulfobenzoic acid 8.6
Fludrocortisone acetate 8.6
Trichlormethiazide 8.4
Glycerophosphocholine 8.4
Cytochalasin E 7.9
11,12-EET 7.8
DTMA 7.8
Benzamil 7.7
Amiloride 7.4
hexanamide 7.4
NPPB 7.2
Biopterin 7.0
8-HETE 7.0
aldosterone 7.0
Methazolamide 6.9
Kallidin 6.9
DIDS 6.9
Meclofenamate 6.9
Desmopressin 6.8
Triamterene 6.8
14,15-DHET 6.8
Angiotensin IV 6.8
DDMS 6.8
Monastral Blue 6.8
HCO 6.7
Guanabenz 6.7
Guggulsterone 6.6
Acetazolamide 6.5
NBC 6.5
Diisopropyl fluorophosphate 6.4
Nedaplatin 6.4
Phloretin 6.4
Chelerythrine 6.3
Chelerythrine 6.3
CHIP 6.3
Thiazide 6.2
DTBP 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.2
carbonic acid 6.1
carbonic acid 6.1
carbonic acid 6.1
carbonic acid 6.1
carbonic acid 6.1
carbonic acid 6.1
carbonic acid 6.1
Fenoldopam 6.1
DOCA 6.1
carbonic acid 6.1
3'-AMP 6.1
Lithium chloride 6.1
carbonic acid 6.1
Spironolactone 6.1
Sorbitol 6.0
Luminal 6.0
Jasplakinolide 6.0
Candesartan 6.0
BQ 123 5.9
Oxymetazoline 5.9
TSC 5.9
3,4,5-trimethoxybenzoic acid 5.8
Lithium 5.8
more...