Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P41181 (collecting duct)
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Human Gene/Protein
VIT32 12.6
COMMD2 12.6
VIP32 12.6
xGPAT1 12.6
FHAD1 12.6
Rh type B glycoprotein 12.6
PCD9 12.6
collecting duct 12.6
synaptotagmin VIII 12.6
AQP2 protein 12.1
KIAA1185 11.6
RCCD1 11.6
chloride channel CLC-5 11.6
V-ATPase B1 subunit 11.6
Histone H4 gene 11.6
Aquaporin-2 mutant 11.6
aquaporin 2 11.5
MIWC 11.4
cGMP-gated cation channel protein 11.3
dyf-13 11.0
aquaporin 6 11.0
Transmembrane protein 174 11.0
glycerophosphodiester phosphodiesterase domain containing 5 11.0
AQP2 11.0
Aquaporin adipose 10.9
UT-A2 10.8
RNF183 10.7
ENaCalpha 10.6
ENaCgamma 10.6
N4WBP5A 10.6
TMEM51 10.6
kinesin family member 3B 10.6
GPR80 10.5
AE2 anion exchanger 10.5
aquaporin-3 10.4
MCD4 10.4
ROMK 10.4
ClC-K2 10.4
AKAP18 10.4
CHIP28 10.3
more...
Disease
Acquired nephrogenic diabetes insipidus 11.6
Renal coccidiosis 11.0
Congenital nephrogenic diabetes insipidus 10.8
Bellini duct carcinoma 10.6
Familial central diabetes insipidus 10.6
nephrogenic diabetes insipidus 10.3
Chronic hyperkalemia 10.3
NSIAD 10.3
Metanephric adenofibroma 10.0
FH II 10.0
Chromophobe cell renal carcinoma 9.4
Distal renal tubular acidosis 9.4
Liddle's syndrome 9.2
antidiuresis 9.2
Colonic pseudo-obstruction 8.8
Autosomal recessive polycystic kidney disease 8.7
Polyomavirus-associated nephropathy 8.6
NPHP2 8.6
PHA2 8.6
Gordon's syndrome 8.4
Cystic kidney disease 8.3
Renal oncocytoma 8.2
Renal tubular dysfunction 8.0
hyperosmolality 7.9
Dent's disease 7.9
NDI 7.9
Ask-Upmark kidney 7.8
sponge kidney 7.8
Mesoblastic nephroma 7.7
Hereditary Leiomyomatosis and Renal Cell Cancer 7.7
renal tubular acidosis 7.7
pelvic neoplasm 7.6
polycystic kidney 7.5
gouty nephropathy 7.5
Pseudohypoaldosteronism 7.5
renal papillary necrosis 7.5
MKS3 7.5
NPHP3 7.4
BSND 7.3
Bartter's syndrome 7.3
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Symptom
excessive urination 9.6
polyuria 8.1
Macula 7.3
polydipsia 6.8
male puberty 6.1
Cushingoid 4.8
Cushingoid 4.8
rundown 4.6
abdominal fullness 3.9
oliguria 3.7
Decreased activity 3.5
ketonuria 3.5
persistent cough 3.3
flank pain 3.1
chest tightness 3.0
renal colic 2.9
hypercapnia 2.2
bitter taste 2.1
enuresis 1.9
hypocapnia 1.9
back pain 1.3
functional recovery 1.2
lethargy 1.1
flushing 0.9
low back pain 0.9
constipation 0.8
acidity 0.7
anorexia 0.4
acute stress 0.4
dizziness 0.3
numbness 0.2
shortness of breath 0.2
hunger 0.1
collapse 0.1
tinnitus -0.1
weakness -0.3
vomiting -0.4
tremor -0.6
syncope -0.6
splenomegaly -0.7
more...
Drug
DOCP 9.6
Demeclocycline 8.2
Micardis 8.1
Imidafenacin 8.1
Sulprostone 7.9
RPH 7.8
Camostat mesilate 7.8
Tolvaptan 7.6
Amiloride 7.4
Amiloride 7.2
Piretanide 6.9
Parecoxib 6.8
Butaprost 6.6
Nafamostat mesilate 6.6
Chlorothiazide 6.6
DDAVP 6.3
Aliskiren 6.1
DDAVP 6.1
Fenoldopam 6.0
Torasemide 5.9
Bumetanide 5.9
Bosentan 5.9
Bosentan 5.9
Plavix 5.6
Roflumilast 5.6
Roflumilast 5.6
Hydrochlorothiazide 5.5
ETA 5.4
Ouabain 5.3
KGF 5.3
Atipamezole 5.2
Felodipine 5.1
Forskolin 5.0
Carbenoxolone 5.0
Diamminedichloroplatinum 4.9
Olmesartan 4.9
NH3 4.8
Phosphoramidon 4.8
Angiotensin II 4.8
Valsartan 4.7
more...
Enzyme
prostasin 9.0
site-1 protease 8.4
H,K-ATPase 8.3
glycerophosphocholine phosphodiesterase 8.0
RPH 7.9
site-1 protease 7.4
11beta-hydroxysteroid dehydrogenase 6.6
ubiquitin-protein ligase 6.3
matrix metalloproteinase 14 6.1
gluconate dehydrogenase 6.1
carbonic anhydrase 5.9
ketohexokinase 5.9
ADH 5.9
DAP II 5.8
alpha-methylacyl-CoA racemase 5.8
ATPase 5.8
AMP-activated kinase 5.7
N-acetylgalactosaminidase 5.5
cGMP phosphodiesterase 5.5
fumarase 5.4
PKG 5.4
oxaloacetate decarboxylase 5.2
sorbitol dehydrogenase 5.1
DCF 5.1
tissue kallikrein 5.1
aldose reductase 5.0
PIP kinase 4.9
phosphocholine cytidylyltransferase 4.8
aminopeptidase B 4.8
proton-translocating ATPase 4.8
inositol 3-kinase 4.7
oxytocinase 4.7
sphingomyelin synthase 4.7
endo-N 4.7
ornithine aminotransferase 4.7
guanylate cyclase 4.7
estrogen sulfotransferase 4.7
renin 4.6
kallikrein 4.6
ADH3 4.6
more...
Compound
2-Bromoethylamine hydrobromide 11.0
2-Bromoethylamine hydrobromide 11.0
8-Aminoguanine 10.6
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
8-Bromoadenosine 8.8
Vasopressin 8.7
Fludrocortisone acetate 8.6
2-sulfobenzoic acid 8.6
Trichlormethiazide 8.4
Glycerophosphocholine 8.4
Cytochalasin E 7.9
11,12-EET 7.8
DTMA 7.8
Benzamil 7.7
Amiloride 7.4
hexanamide 7.4
NPPB 7.2
Biopterin 7.0
8-HETE 7.0
aldosterone 7.0
Methazolamide 6.9
Kallidin 6.9
DIDS 6.9
Meclofenamate 6.9
Desmopressin 6.8
Triamterene 6.8
14,15-DHET 6.8
Angiotensin IV 6.8
DDMS 6.8
Monastral Blue 6.8
HCO 6.7
Guanabenz 6.7
Guggulsterone 6.6
Acetazolamide 6.5
NBC 6.5
more...