Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P41181 (
collecting duct
)
5,183
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
SLC4A11
is a multifunctional membrane transporter involved with H
+
transport, NH
3
and alkaline pH stimulated H
+
transport, and water transport. The role of
SLC4A11
in the kidney is not well understood. A prior study has shown that in murine kidney,
SLC4A11
/LacZ staining is primarily in the long-looped descending thin limb (DTL) as determined by colocalization with aquaporin 1 (AQP1), a protein that is expressed in some, but not all, descending thin limb segments. Using a previously characterized polyclonal antibody, we demonstrate the selective expression of
SLC4A11
in the upper DTLs (which are AQP1-positive) in the outer medulla and inner medulla with little or no expression in the lower DTLs (which are AQP-1-null).
SLC4A11
also colocalized with AQP1 and the urea transporter UT-B in the mouse descending vasa recta, but was absent in mouse and rat ascending vasa recta. Mouse, but not rat, outer medullary
collecting duct
cells also labeled for
SLC4A11
. Our results are compatible with the hypothesis that in the inner stripe of the outer medulla,
SLC4A11
plays a role in the countercurrent transport of ammonia absorbed from the outer medullary thick ascending limb and secreted into the long-looped DTLs.
SLC4A11
can potentially modulate the rate of ammonia transport in the mouse outer medullary
collecting duct
. Our data suggest functionally unique
SLC4A11
pathways in mouse and rat and complement previous studies of DTL Na
+
, urea and water permeability indicating that the upper and lower DTLs of long-looped nephrons are functionally distinct.
...
PMID:Expression of SLC4A11 protein in mouse and rat medulla: a candidate transporter involved in outer medullary ammonia recycling. 3112 1
