Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P41181 (
collecting duct
)
5,183
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Expression of
KRT17
has been described in multi-layered epithelia as well as in tumors derived from these cells. In cancers arising from
KRT17
negative single layered epithelia neo-expression of
KRT17
has been associated with tumor progression. To obtain more insight into the biology of kidney cancers we have investigated
KRT17
expression by immunohistochemistry in normal kidney, in papillary preneoplastic lesions and in 151 papillary and 692 conventional renal cell carcinomas placed on tissue microarray. We found a positive staining in ureteric bud and
collecting duct
cells in foetal kidney, in all papillary preneoplastic lesions and also in 77% of the 151 papillary renal cell tumors indicating a continuos
KRT17
expression during tumor development. The neo-expression of
KRT17
in conventional renal cell carcinomas, which derives from
KRT17
negative proximal tubules showed a significant correlation with postoperative tumor relapse (RR=2.50; 95% CI=1.59-3.94; p<0.001). In conclusion, the continuous expression of
KRT17
from emerging fetal kidney tubules and microscopic pre-neoplastic lesions towards papillary renal cell tumors and its neo-expression in aggressive growing conventional renal cell carcinomas reflects the multiple function of
KRT17
in kidney cancers with distinct natural history. This should be taken into account in clinical managements and therapy.
...
PMID:Dual role of
KRT17
: development of papillary renal cell tumor and progression of conventional renal cell carcinoma. 3160 65
