Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P41181 (
collecting duct
)
5,183
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kinins are vasoactive peptides that stimulate two G-protein coupled bradykinin receptors (
B1R
and B2R). B2R-knockout mice are salt sensitive and develop renal dysgenesis and hypertension if salt stressed during embryogenesis.
B1R
-knockout mice, on the other hand, are protected from inflammation and fibrosis. This study examined the spatiotemporal expression of
B1R
during renal organogenesis. The segmental nephron identity of
B1R
immunoreactivity was determined by costaining with markers of the
collecting duct
(Dolichos biflorus), proximal tubule (Dolichos tetraglonus), and nephron progenitors (Pax2). At E14.5, the
B1R
was confined to few cells in the metanephric mesenchyme. Abundance of
B1R
increased progressively during development. On E17.5,
B1R
was enriched in differentiating proximal tubular cells and by postnatal day 1,
B1R
was clearly expressed on the luminal aspect of the proximal tubule. Quantitative real-time PCR revealed that the levels of
B1R
mRNA more than double during renal maturation. We conclude that 1)
B1R
expression correlates closely with nephron maturation; 2) lack of
B1R
in nephron progenitors suggests that
B1R
is unlikely to play a role in early nephrogenesis; and 3) enrichment of
B1R
in maturing proximal tubule suggests a potential role for this receptor in terminal differentiation of the proximal nephron.
...
PMID:Ontogeny of bradykinin B1 receptors in the mouse kidney. 1958 23
