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Query: UNIPROT:P41181 (collecting duct)
 5,183 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen cases of papillary adenocarcinoma of the kidney are presented. The lesions were polycystic in gross appearance. Histologically, they were subdivided into three types: papillary cystadenocarcinoma, papillary oncocytic cystadenocarcinoma and papillary mucinous cystadenocarcinoma. Immunohistochemically, the tumor cells demonstrated positive reactivity for high molecular weight keratin and glandular lumina membrane positivity for EMA, which support a collecting duct origin for the tumor. Most of the tumors were large (average diameter 9.6 cm) and invasion of perinephric tissues was observed in 80% of the cases, an indication of its aggressive behavior. As most of the tumors occurred in the medulla and invaded the collecting ducts, the clinical manifestations were different from those of renal cell carcinomas.
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PMID:[A clinicopathologic study of 15 cases of collecting duct carcinoma of the kidney]. 751 58

The clear, chromophilic, and chromophobe types of human renal cell carcinoma have been defined as distinct morphological entities and can be clearly separated by differences of ultrastructural appearance, cytoskeletal architecture, enzyme synthesis, and cytogenetic aberrations. In this report, the cytomorphological aspects of these tumor types are compared in vitro, showing that essential ultrastructural and cytoskeletal characteristics of each tumor type are expressed even after prolonged in vitro cultivation. The pattern of intermediate filament proteins of each tumor type was preserved in vitro, permitting the separation of exclusively cytokeratin-positive chromophobe tumor cells from clear and chromophilic tumor cells with a co-expression of vimentin and cytokeratins. In vitro, the chromophobe tumor cells continued to exhibit abundant cytoplasmatic microvesicles and sparsely distributed "studded" vesicles, which are known to be characteristic features of this tumor type in vivo. This observation confirmed the structural similarity of the chromophobe cell to the 'intercalated cell' of the cortical collecting duct and provided further evidence for the histogenetic derivation of this tumor subtype from the collecting duct system.
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PMID:Ultrastructural appearance and cytoskeletal architecture of the clear, chromophilic, and chromophobe types of human renal cell carcinoma in vitro. 768 Dec 59

The chromophobe renal cell carcinoma is a distinct type of renal cancer presumably derived from the intercalated cell of the collecting duct system and exhibiting a better prognosis than other types of renal cell carcinoma. Chromophobe carcinomas can be separated from other types of renal cell carcinoma by their characteristic cytomorphology, ultrastructural appearance, cytoskeletal architecture, and cytogenetic aberrations. As no permanent cell line of the chromophobe tumor type has previously been described, we are the first to report on the successful establishment and characterization of two divergent permanent cell lines, ie, chrompho-A and chrompho-B, derived from the same chromophobe renal cell carcinoma. With immunocytochemistry, two-dimensional gel electrophoresis, and Western blot, chrompho-A and chrompho-B exclusively exhibited cytokeratins (Nos. 7, 8, 18, and 19) but not vimentin. Ultrastructural studies revealed numerous cytoplasmic microvesicles as well as coated vesicles that are known to be characteristic features of the intercalated cell. Chrompho-B cells exhibited a shorter mean population doubling time (tD = 43 hours) than chrompho-A cells (tD = 51 hours). Both cell lines failed to produce tumors in nude mice with the subrenal capsule assay. Cytogenetic analyses revealed hyperdiploid chromosome numbers in both cell lines with telomeric associations as well as numeric aberrations known from chromophobe renal cell carcinomas in vivo.
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PMID:Establishment and characterization of two divergent cell lines derived from a human chromophobe renal cell carcinoma. 771 62

The consideration of adult renal epithelial neoplasms is no longer limited to renal adenocarcinoma, but also includes oncocytoma, chromophobe carcinoma, renal papillary neoplasms, collecting duct carcinoma, and neuroendocrine tumors. The recent application of classical and molecular cytogenetic techniques, particularly the studies of Kovacs and colleagues, has provided a biologic basis for this new classification. This review discusses the clinical and pathologic characteristics of these entities, with attention to differential diagnosis. Prognostic factors in renal adenocarcinoma are also discussed.
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PMID:Adult renal epithelial neoplasms. 774 Nov 11

We report a rare case of collecting duct carcinoma of the kidney (Bellini's duct carcinoma). A 37-year-old woman visited our hospital with a chief complaint of asymptomatic hematuria. We suspected right renal pelvic tumor from the detection of round filling defects in the upper calyces of the right kidney by image diagnoses. A ureteroscopic biopsy revealed a low grade renal cell carcinoma. Therefore, she received right partial nephrectomy immediately. Histological examination of the surgical specimen showed a highly differentiated adenocarcinoma with papillary proliferation besides the collecting duct epithelium. With the results of the strongly positive patterns of immunohistochemical staining with high molecular cytokeratin and peanut aggulutinin, the tumor corresponded to the distal nephrons. Therefore we made the diagnosis of Bellini's duct carcinoma. She had been alive without evidence of metastases for one year after surgery.
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PMID:[Bellini duct carcinoma treated with partial nephrectomy: a case report]. 786 63

Cytogenetic deletions and loss of heterozygosity (LOH) at certain restriction fragment length polymorphic (RFLP) loci on the short arm of chromosome 3 occur in most nonpapillary clear cell variants of renal cell carcinoma (RCC). Studies of other variants of renal cell carcinomas are sparse and inconclusive. We investigated the LOH at three of the most commonly deleted loci on the short arm of chromosome 3 in 50 neoplasms representing the histopathologic spectrum of renal cortical neoplasms by polymerase chain reaction (PCR)-based restriction fragment length polymorphism assay and Southern blotting analysis. Our results indicate that PCR-based RFLP analysis accurately identified the LOH on the short arm of chromosome 3 in the different histopathologic variants of renal neoplasms. LOH was observed at D3F15S2 locus (3p21 telomeric) in > 60% of nonpapillary renal cell carcinomas. In contrast, 1 of 6 papillary renal cell carcinomas showed LOH at D3S32 locus (3p21 centromeric), and one of seven oncocytomas demonstrated LOH at D3F15S2 locus. We also report that 1 of 3 collecting duct carcinomas showed LOH at D3S32 locus. In this series there was no correlation between LOH, histologic grade, tumor stage, and DNA content. We conclude that (a) LOH on 3p is not restricted to the clear cell type of RCC, (b) the most common LOH were telomeric to D3S32 locus at the 3p21 region, and (c) no statistical correlation between the LOH at 3p and histologic grade, DNA ploidy, or clinical stage was found in this series.
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PMID:PCR-based RFLP screening of the commonly deleted 3p loci in renal cortical neoplasms. 790 93

Intratubular epithelial dysplasia (IED) of the renal tubules has not been fully described in human renal cell carcinoma (RCC). This lesion has been found in male Syrian hamsters exposed to estrogens. One article reports IED in human kidney showing nephrosclerosis and RCC. We examined "normal" kidney tissue adjacent to 110 cases of RCC in an attempt to identify possible precursor lesions. There were 73 male and 37 female patients (M/F = 2:1). The ages ranged from 27 to 86 years (median 64 years). IED was identified in 30 cases. The lesions consisted of foci of crowded tubular epithelium with large, vesicular nuclei two to three times the size of nuclei of benign tubular cells with eosinophilic macronucleoli. The tubules were occasionally filled with dysplastic cells mimicking carcinoma in situ. The lesions were predominantly cortical and periglomerular. They either were subtle and focal or, less commonly, involved tubules diffusely. Eighteen of the 73 male patients (24%) had these lesions compared with 12 of 37 female patients (32%). They were more usually seen in the clear cell (21 of 66) and sarcomatoid (three of four) variants of RCC than in the oncocytic/granular cell (four of 25) or tubulopapillary (two of 14) variants. One case of collecting duct RCC showed no evidence of IED. Immunohistochemical assessment of 20 dysplastic and 20 nondysplastic lesions with their adjacent RCC for cytokeratin, vimentin, cathepsin-D, and epidermal growth factor receptors was inconclusive. Our findings suggest that IED associated with RCC might represent previously unrecognized precursor lesions along the spectrum ranging from dysplasia to frank carcinoma. The biological significance of these lesions, their preponderance in women, and the phenotypic and genotypic characteristics require further investigation.
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PMID:Dysplastic tubular epithelium in "normal" kidney associated with renal cell carcinoma. 757 98

Band 3 protein is an anion-exchange protein that in the human kidney is restricted to a subpopulation of collecting duct-intercalated cells; however, it is absent in the metanephric-derived cells of the nephron. We have studied band 3 protein expression in a series of 60 renal tumors that included 10 oncocytomas, 42 renal cell carcinomas, and eight nephroblastomas by using frozen tumors and a monoclonal antibody. We detected band 3 protein expression in nine of 10 oncocytomas but not in any renal cell carcinomas or nephroblastomas. This finding confirms that band 3 protein is a specific marker for oncocytoma and therefore may have a potential diagnostic application. It also supports the contention that renal cell carcinoma and oncocytoma are histogenically unrelated; the former is metanephric blastema derived and the latter is ampullary bud derived.
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PMID:Immunocytochemical analysis of band 3 protein in renal cell carcinoma, nephroblastoma, and oncocytoma. 802 3

We report a case of an atypical renal adenocarcinoma of the renal medulla associated with a marked desmoplastic response and interstitial mucin production. Collecting duct epithelium of the renal medulla throughout the kidney showed cytologic atypia. These features have been described by others as suggestive of a collecting duct histogenesis. This case represents the fifteenth reported case known to us of a renal adenocarcinoma of collecting duct origin. Prior reports, however, have not described the extensive mucin production that may be associated.
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PMID:Atypical renal adenocarcinoma with features suggesting collecting duct origin and mimicking a mucinous adenocarcinoma. 838 90

The present investigation is based on the morphological analysis of 1224 renal cell carcinomas and 68 renal oncocytomas from the kidney tumor registry of the Institute of Pathology, University of Mainz. The subclassification of epithelial renal cell tumors in 5 basic types (i.e. clear cell type, chromophilic type, chromophobic type, oncocytic type and duct Bellini type) as proposed by Thoenes and coworkers (1986) was taken as the basis for a systematical study. It refers especially to ultrastructural aspects and antigen profiles of the tumor cells established immunohistologically in relation to the nephron/collecting duct epithelia. Thus, the study focuses on problems of phenotypia and histogenesis. Finally, morphological parameters of prognosis in renal cell carcinomas are taken into account as well. I. Ultrastructural analysis provides further knowledge of the morphological differences between the various basic cell types of epithelial renal tumors. Structural similarities are presented between the basic cell types of clear cell and chromophilic renal cell carcinomas and cells of the proximal tubules, on the one hand, and the basic cell types of the chromophobic renal cell carcinomas, duct Bellini carcinomas as well as oncocytomas and cells of the collecting duct, on the other hand. This can sometimes be traced back to the single cell level (chromophobic renal cell carcinomas: intercalated cell type B). The results of the freeze fracture analysis confirm this view and, for the first time, morphologically prove molecular anomalies of the oncocytic mitochondria membrane. Initial tumor development can be observed for the chromophilic renal cell carcinoma, the duct Bellini carcinoma, as well as the renal oncocytoma and chromophobic renal cell carcinoma. This development demonstrates the relationship these tumor types have to well-defined segments of the nephron/collecting duct (i.e. proximal tubule, medullary and cortical collecting duct). II. The immunohistological analysis demonstrates characteristic antigen profiles of every renal tubule segment and of every epithelial renal tumor type which can be used for differential diagnosis purposes. Two tumor groups with different morphological phenotypes can be identified. The first group (clear cell and chromophilic renal cell carcinomas) mostly presents antigens of the proximal tubule, while the second group (chromophobic renal cell carcinomas, duct Bellini carcinomas, oncocytomas) mostly expresses antigens of the collecting duct. In the case of the renal oncocytomas, for example, the expression of the band 3 antigen exhibits a relationship to the single cell level (i.e. the intercalated cells type A).(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Carcinoma and oncocytoma of the kidney. Phenotypic characteristics and prognostic features]. 843 85


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